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Tibial dyschondroplasia – tools, new insights and future prospects

Published online by Cambridge University Press:  18 September 2007

M. Pines ,
A. Hasdai  and
E. Monsonego-Ornan
M. Pines*
Affiliation:
Institute of Animal Science, the Volcani Center, Bet Dagan 50250, Israel
A. Hasdai
Affiliation:
Institute of Animal Science, the Volcani Center, Bet Dagan 50250, Israel
E. Monsonego-Ornan
Affiliation:
Institute of Animal Science, the Volcani Center, Bet Dagan 50250, Israel
*
*Corresponding author: pines@agri.huji.ac.il
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Abstract

Tibial Dyschondroplasia (TD) is one of the most prevalent skeletal abnormalities observed in avian species; it causes enormous economic losses and is a major animal welfare problem. It is characterized by lesions composed of uncalcified, unvascularized cartilage that can extend from the epiphyseal growth plate into the metaphysis. The disease development and progress have been attributed to dietary, environmental and genetic factors. Irregular cell differentiation of the chondrocytes that populate the growth plate, with consequently aberrant cartilage vascularization and mineralization, has been hypothesized to be involved in the etiology of the disease.

Various tools available for the study of TD are described in the present review, and their advantages and limitations are discussed. We describe the morphology of the growth plate, with especial emphasis on the differences between the mammalian and the avian ones. We highlight vascularization as a possible cause of TD, and suggest that matrix metalloproteinases (MMPs) play an important role in cartilage vascularization and TD development. The disparity between broilers and turkeys MMPs suggests that they differ in their regulation of vascularization, so that different strategies may be required in dealing with TD in broilers and in turkeys. The high body mass of the modern meat-type birds has been implicated in the development of TD. A model was established to evaluate the effect of mechanical loading on the bones of young chickens, without any dietary manipulations: increased loading caused enhanced vascularization of the growth plate together with increased MMP-9 expression, without any changes in the incidence of TD, which suggests that the increased loading is not in itself the cause of TD.

At present, the cause of TD is not known, but multidisciplinary research at various levels such as a genomic approach based on microarray technology and the chicken genome project, together with cell and organ culture methodology, genetic selection, nutritional manipulation and environmental approaches will provide us with better understanding of the molecular mechanisms underlying TD, and should pave the way for future reduction in its incidence.

Keywords

growth platevascularizationchondrocytesmatrix metalloproteinase
Type
Reviews
Information
World's Poultry Science Journal , Volume 61 , Issue 2 , June 2005 , pp. 285 - 297
Copyright
Copyright © Cambridge University Press 2005

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References

Bai, Y. and Cook, M.E. (1994) Histological study of tibial dyschondroplasia-like lesion from light-type chicks fed cysteine-supplemented diets. Avian Disease 38: 557–562.CrossRefGoogle ScholarPubMed
Barak-Shalom, T., Schindler, M., Knopov, V., Shapira, R., Hurwitz, S. and Pines, M. (1995) Synthesis and phosphorylation of osteopontin by avian epiphyseal growth-plate chondrocytes as affected by differentiation. Comparative Biochemistry and Physiology 111C: 49–59.Google Scholar
Bashey, R.I., Leach, R.M., Gay, C.V. and Jimenez, S.A. (1989) Type X collagen in avian tibial dyschondroplasia. Laboratory Investigation 60: 106–112.Google ScholarPubMed
Ben-Bassat, S., Genina, O., Lavelin, I., Leach, R.M. and Pines, M. (1999) Parathyroid receptor gene expression by epiphyseal growth plates in rickets and tibial dyschondroplasia. Molecular and Cellular Endocrinology 149: 185–195.CrossRefGoogle ScholarPubMed
Breur, G.J., Vanenkevort, B.A., Farnum, C.E. and Wilsman, N.J. (1991) Linear relationship between the volume of hypertrophic chondrocytes and the rate of longitudinal bone growth in growth plates. Journal of Orthopedic Research 9: 348–359.CrossRefGoogle ScholarPubMed
Chu, Q., Wu, W., Cook, M.E. and Smalley, E.B. (1996) Elevated plasma glycosaminoglycans in chickens with tibial dyschondroplasia induced by a Fusarium oxysporum isolate. Avian Diseases 403: 715–719.CrossRefGoogle Scholar
Cogburn, L.A., Wang, X., Carre, W., Rejto, L., Porter, T.E., Aggrey, S.E. and Simmon, J. (2003) Systems-wide chicken DNA microarrays, gene expression profiling, and discovery of functional genes. Poultry Science 82: 939–951.CrossRefGoogle ScholarPubMed
Di Nino, D.L., Long, F. and Linsenmayer, T.F. (2001) Regulation of endochondral cartilage growth in the developing avian limb: cooperative involvement of perichondrium and periosteum. Developmental Biology 240: 433–442.CrossRefGoogle ScholarPubMed
Edwards, H.M. (2000) Nutrition and skeletal problems in poultry. Poultry Science 79: 1018–1023.CrossRefGoogle ScholarPubMed
Elliot, M.A. and Edwards, H.M. Jr. (1997) Effect of 1,25-dihydroxycholecalciferol, cholecalciferol, and fluorescent lights on the development of tibial dyschondroplasia and rickets in broiler chickens. Poultry Science 76: 570–580.CrossRefGoogle ScholarPubMed
Farquharson, C. and Jefferies, D. (2000) Chondrocytes and longitudinal bone growth: the development of tibial dyschondroplasia. Poultry Science 79: 994–1004.CrossRefGoogle ScholarPubMed
Farquharson, C., Berry, J.L., Mawer, E.B., Seawright, E. and Whitehead, C.C. (1995) Regulators of chondrocyte differentiation in tibial dyschondroplasia: an in vivo and in vitro study. Bone 17: 279–286.CrossRefGoogle ScholarPubMed
Farquharson, C., Lester, D., Seawright, E., Jefferies, D. and Houston, B. (1999) Microtubules are potential regulators of growth-plate chondrocyte differentiation and hypertrophy. Bone 25: 405–412.CrossRefGoogle ScholarPubMed
Gay, C.V., Anderson, R.E. and Leach, R.M. (1985) Activities and distribution of alkaline phosphatase and carbonic anhydrase in the tibial dyschondroplastic lesion and associated growth plate of chicks. Avian Disease 29: 812–821.CrossRefGoogle ScholarPubMed
Hargest, T.E., Leach, R.M. and Gay, C.V. (1985) Avian tibial dyschondroplasia. I. Ultrastructure. American Journal of Pathology 119: 175–190.Google ScholarPubMed
Halevy, O., Schindler, D., Hurwitz, S. and Pines, M. (1991) Epidermal growth factor receptor gene expression in avian epiphyseal growth-plate cartilage cells: effects of serum, parathyroid hormone and atrial natriuretic peptide. Molecular and Cellular Endocrinology 75: 229–235.CrossRefGoogle ScholarPubMed
Halevy, O., Monsonego, E., Marcelle, C., Hodik, V., Mett, A. and Pines, M. (1994) A new avian fibroblast growth factor receptor in myogenic and chondrogenic cell differentiation. Experimental Cell Research 212: 278–284.CrossRefGoogle ScholarPubMed
Huff, W.E. (1980) Evaluation of tibial dyschondroplasia during aflatoxicosis and feed restriction in young broiler chickens. Poultry Science 59: 991–995.CrossRefGoogle ScholarPubMed
Hurwitz, S., Livne, E., Plavnik, I., Pines, M. and Silberman, M. (1992) Tibial development in turkeys and chickens as affected by early age feed restriction. Growth, Development and Aging 56: 191–203.Google ScholarPubMed
Kember, N.F., Kirkwood, J.K., Duignan, P.J., Godfrey, D. and Spratt, D.M. (1990) Comparative cell kinetics of avian growth plates. Research in Veterinary Science 49: 283–288.CrossRefGoogle ScholarPubMed
Knopov, V., Hadash, D., Hurwitz, S., Leach, R.M. and Pines, M. (1997) Gene expression during cartilage differentiation in turkey tibial dyschondroplasia, evaluated by in situ hybridization. Avian Disease 41: 62–72.CrossRefGoogle ScholarPubMed
Leach, R.M. and Gay, C.V. (1987) Role of epiphyseal cartilage in endochondral bone formation. Journal of Nutrition 117: 784–790.CrossRefGoogle ScholarPubMed
Leach, M.R. and Lilburn, M.S. (1992) Current knowledge on the etiology of tibial dyschondroplasia in the avian species. Poultry Science Review 4: 57–65.Google Scholar
Leach, R.M. and Nesheim, M.C. (1972) Further studies on tibial dyschondroplasia (cartilage abnormality) in young chicks. Journal of Nutrition 102: 1673–1680.CrossRefGoogle ScholarPubMed
Leblanc, B., Wyers, M., Cohn-Bendit, F., Legall, J.M., Thibaulth, E. and Florentl, J.M. (1986) Histology and histomorphometry of the tibial growth in two turkey strains. Poultry Science 65: 1787–1795.CrossRefGoogle ScholarPubMed
Ledwaba, M.F. and Roberson, K.D. (2003) Effectiveness of twenty-five-hydroxycholecalciferol in the prevention of tibial dyschondroplasia in Ross cockerels depends on dietary calcium level. Poultry Science 82: 1769–1777.CrossRefGoogle ScholarPubMed
Ling, J., Kincaid, S.A., McDaniel, G.R. and Waegell, W. (2000) Immunolocalization analysis of transforming growth factor-beta1 in the growth plates of broiler chickens with high and low incidences of tibial dyschondroplasia. Poultry Science 79: 1172–1178.CrossRefGoogle ScholarPubMed
Minina, E., Wenzel, H.M., Kreschel, C., Karps, S., Gaffield, W., McMahon, A.P. and Vortkamp, A. (2001) BMP and Ihh/lPTHrP signalling interact to coordinate chondrocyte proliferation and differentiation. Development 128: 4523–4534.CrossRefGoogle ScholarPubMed
Mitchell, R.D., Edwards, H.M., and McDaniel, G.R. (1997a) The effects of ultraviolet light and cholecalciferol and its metabolites on the development of leg abnormalities in chickens genetically selected for a high and low incidence of tibial dyschondroplasia. Poultry Science 76: 346–354.CrossRefGoogle ScholarPubMed
Mitchell, R.D., Edwards, H.M., McDaniel, G.R. and Rowland, G.N. (1997b) Dietary 1,25-dihydroxycholecalciferol has variable effects on the incidences of leg abnormalities, plasma vitamin D metabolites, and vitamin D receptors in chickens divergently selected for tibial dyschondroplasia. Poultry Science 76: 338–345.CrossRefGoogle ScholarPubMed
Monsonego, E., Halevy, O., Gertler, A., Volokita, M., Schickler, M., Hurwitz, S. and Pines, M. (1993) Growth hormone receptors in avian epiphyseal growth-plate chondrocytes. General and Comparative Endocrinology 92: 179–188.CrossRefGoogle ScholarPubMed
Monsonego, E., Baumbach, W.R., Lavelin, I., Gertler, A., Hurwitz, S. and Pines, M. (1997) Generation of growth hormone binding protein by avian growth plate chondrocytes is dependent on cell differentiation. Molecular and Cellular Endocrinology 135: 1–10.CrossRefGoogle ScholarPubMed
Nagai, H. and Aoki, M. (2002) Inhibition of growth plate angiogenesis and endochondral ossification with diminished expression of MMP-13 in hypertrophic chondrocytes in FGF-2-treated rats. Journal of Bone Mineral Metabolism 20: 142–147.CrossRefGoogle ScholarPubMed
Nie, D., Genge, B.R., Wu, L.N. and Wuthier, R.E. (1995) Defect in formation of functional matrix vesicles by growth plate chondrocytes in avian tibial dyschondroplasia: evidence of defective tissue vascularization. Journal of Bone Mineral Research 10: 1625–1634.CrossRefGoogle ScholarPubMed
Orth, M.W. and Cook, M.E. (1994) Avian tibial dyschondroplasia: A morphological and biochemical review of the growth plate lesion and its cause. Veterinary Pathology 31: 403–414.CrossRefGoogle Scholar
Peters, T.L., Fulton, R.M., Roberson, K.D. and Orth, M.W. (2002) Effect of antibiotics on in vitro and in vivo avian cartilage degradation. Avian Disease 46: 75–86.CrossRefGoogle ScholarPubMed
Pines, M. and Hurwitz, S. (1991) The role of the growth plate in longitudinal bone growth. Poultry Science 70: 1806–1814.CrossRefGoogle ScholarPubMed
Pines, M., Monsonego, E., Shalom-Barak, T., Halevy, O. and Hurwitz, S. (1993) Effect of hormones and growth factors on cell proliferation and synthesis of extracellular protein by epiphyseal growth plate chondrocytes. In: Avian Endocrinology Ed. Sharp, P.J.249–260.Google Scholar
Pines, M., Knopov, V., Genina, O., Hurwitz, S., Faerman, A., Gerstenfeld, L.C. and Leach, R.M. (1999) Development of avian tibial dyschondroplasia: Gene expression and protein synthesis. Calcified Tissue International 63: 521–527.CrossRefGoogle Scholar
Poulos, P.W., Reiland, S., Elwinger, K. and Olsson, S.E. (1978) Skeletal lesions in the broiler, with special reference to dyschondroplasia (osteochondrosis). Pathology, frequency and clinical significance in two strains of birds on high and low energy feed. Acta Radiologia Supplement 358: 229–275.Google ScholarPubMed
Praul, C.A., Gay, C.V., and Leach, R.M. (1997). Chondrocytes of the tibial dyschondroplastic lesion are apoptotic. International Journal Development Biology 41: 621–626.Google ScholarPubMed
Praul, C.A., Ford, B.C., Gay, C.V., Pines, M. and Leach, R.M. (2000). Gene expression and tibial dyschondroplasia. Poultry Science 79: 1009–1013.CrossRefGoogle ScholarPubMed
Praul, C.A., Ford, B.C., Gay, C.V. and Leach, R.M. (2002) Effect of fibroblast growth factors 1, 2, 4, 5, 6, 7, 8, 9, and 10 on avian chondrocyte proliferation. Journal of Cell Biochemistry 84: 359–366.CrossRefGoogle ScholarPubMed
Punna, S. and Roland, D.A. (2001) Influence of dietary phytase supplementation on incidence and severity in broilers divergently selected for tibial dyschondroplasia. Poultry Science 80: 735–740.CrossRefGoogle ScholarPubMed
Rath, N.C., Huff, W.E., Balog, J.M., Bayyari, G.R. and Reddy, R.P. (1977) Matrix metalloproteinase activities in avian tibial dyschondroplasia. Poultry Science 76: 501–505.CrossRefGoogle Scholar
Rath, N.C., Huff, W.E., Bayyri, G.R. and Balog, J.M. (1998) Cell death in avian tibial dyschondroplasia. Avian Disease 42: 72–79.CrossRefGoogle ScholarPubMed
Rath, N.C., Huff, W.E., Balog, J.M., and Huff, G.R. (2004) Comparative efficacy of different dithiocarbamates to induce tibial dyschondroplasia in poultry. Poultry Science 83: 266–274.CrossRefGoogle ScholarPubMed
Reich, A., Jaffe, N., Tong, A., Lavelin, I., Genina, O., Pines, M., Sklan, D., Nussinovitch, A., Monsonego-Orman, E., (2005) Weight-loading young chicks inhibits bone elongation and promotes growth-plate ossification and vascularization. J Appl Physiol. In press.CrossRefGoogle ScholarPubMed
Reiland, S., Olsson, S. E., Poulos, P. W. and Elwinger, K. (1978) Normal and pathological skeletal development in broiler and Leghorn chickens. A comparative investigation. Acta Radiologia Supplement 358: 277–298.Google ScholarPubMed
Rennie, J.S. and Whitehead, C.C. (1996) Effectiveness of dietary 25- and 1-hydroxycholecalciferol in combating tibial dyschondroplasia in broiler chickens. British Poultry Science 37: 413–421.CrossRefGoogle ScholarPubMed
Rennie, S. J., Whitehead, C. C. and Thorp, B. H. (1993) The effect of 1,25-dihydroxycholecalciferol in preventing tibial dyschondroplasia in broilers fed on diets imbalance in calcium and phosphorus. British Journal Nutrition 69: 809–816.CrossRefGoogle Scholar
Riddell, C. (1975) Studies on the pathogenesis of tibial dyschondroplasia in chickens. I. Production of a similar defects by surgical intereference. Avian Disease 19: 483–489.CrossRefGoogle Scholar
Riddell, C. (1977) Studies on the pathogenesis of tibial dyschondroplasia in chickens. IV. Some features of the vascular supply to the growth plate of the tibiotarsus. Avian Disease 21: 9–15.CrossRefGoogle Scholar
Riddell, C. and Classen, H.L. (1992) Effects of increasing photoperiod length and anticoccidials on performance and health of roaster chickens. Avian Disease 36: 491–498.CrossRefGoogle ScholarPubMed
Sauveur, B. (1984) Dietary factors as a cause of leg abnormalities – a review. World Poultry Science Journal 40: 195–206.CrossRefGoogle Scholar
Shen, S., Berry, W., Jaques, S., Pillai, S. and Zhu, J. (2004) Differential expression of iodothyronine deiodinase type 2 in growth plates of chickens divergently selected for incidence of tibial dyschondroplasia. Animal Genetics 35: 114–118.CrossRefGoogle ScholarPubMed
Sternlicht, M.D. and Werb, Z. (2001) How matrix metalloroteinases regulate cell behavior. Annual Review of Cell Development Biology 17: 463–516.CrossRefGoogle ScholarPubMed
Su, G., Sorensen, P. and Kestin, S.C. (1999) Meal feeding is more effective than early feed restriction at reducing the prevalence of leg weakness in broiler chickens. Poultry Science 78: 949–955.CrossRefGoogle ScholarPubMed
Takechi, M. and Itakura, C. (1995) Ultrastructural studies of the epiphyseal plate of chicks fed a vitamin D-deficient and low-calcium diet. Journal of Comparative Pathology 113: 101–111.CrossRefGoogle ScholarPubMed
Thorp, B.H., Durco, B., Whitehead, C.C., Farquharson, C. and Sorensen, P. (1993) Avian tibial dyschondroplasia: the interaction of genetic selection and dietary 1,25-dihydroxycholecalciferol. Avian Pathology 22: 311–324.CrossRefGoogle Scholar
Tong, A., Reich, A., Genin, O., Pines, M. and Monsonego-Ornan, E. (2003) Expression of chicken 75-kDa gelatinase B-like enzyme in perivascular chondrocytes suggests its role in vascularization of the growth plate. Journal of Bone Mineral Research 18: 1443–1452.CrossRefGoogle ScholarPubMed
Vaananen, H.K. (1980) Immunohistochemical localization of alkaline phosphatase in the chicken epiphyseal growth plate. Histochemistry 65: 143–148.CrossRefGoogle Scholar
Vu, T.H., Shipley, J.M., Bergers, G., Bergers, J.E., Helms, J.A., Hanahan, D., Shapiro, S.D., Senior, R.M. and Werb, Z. (1998) MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 93: 411–422.CrossRefGoogle ScholarPubMed
Wang, X., Carre, W., Zhou, H., Lamont, S.J. and Cogburn, L.A. (2004). Duplicated Spot 14 genes in the chicken: characterization and identification of polymorphisms associated with abdominal fat traits. Gene 332: 79–88.CrossRefGoogle ScholarPubMed
Whitehead, C.C., McCormack, H.A., McTeir, L. and Fleming, R.H. (2004) High vitamin D3 requirements in broilers for bone quality and prevention of tibial dyschondroplasia and interactions with dietary calcium, available phosphorus and vitamin A. British Poultry Science 45: 425–436.CrossRefGoogle ScholarPubMed
Wise, D.R. and Jennings, A.R. (1972) Dyschondroplasia in domestic poultry. Veterinary Record 16: 285–286.CrossRefGoogle Scholar
Wong-Valle, J., McDanial, G.R., Kuhlers, D.L. and Bartels, J.E. (1993) Divergent genetic selection for incidence of tibial dyschondroplasia in broilers at seven weeks of age. Poultry Science 72: 421–428.CrossRefGoogle ScholarPubMed
Wyers, M., Cherel, Y. and Plassiart, G. (1991) Late clinical expression of lameness related to associated osteomyelitis and tibial dyschondroplasia in male breeding turkeys. Avian Disease 35: 408–414.CrossRefGoogle ScholarPubMed
Zhou, Z., Apte, S.S., Soininen, R., Cao, R., Baaklini, G.Y., Rauser, R.W., Wang, J., Cao, Y. and Tryggvason, K. (2000) Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I. Proceeding of the National Academy of Sciences USA, 97: 4052–4057.CrossRefGoogle ScholarPubMed