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Analysis of transcription factor expression during oogenesis and preimplantation development in mice

Published online by Cambridge University Press:  01 May 2007

S. Kageyama ,
W. Gunji ,
M. Nakasato ,
Y. Murakami ,
M. Nagata  and
F. Aoki
S. Kageyama
Affiliation:
Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8562, Japan.
W. Gunji
Affiliation:
Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Chiba 278-8510, Japan.
M. Nakasato
Affiliation:
Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8562, Japan.
Y. Murakami
Affiliation:
Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Chiba 278-8510, Japan.
M. Nagata
Affiliation:
Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8562, Japan.
F. Aoki*
Affiliation:
Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277-8562, Japan.
*
All correspondence to: Fugaku Aoki, Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Shinryoiki-Seimei Building 302, Kashiwa-no-ha 5–1-5, Kashiwa, Chiba 277-8562, Japan. Tel: +81 4-7136 5424. Fax: +81 4-7136 3698. e-mail: aokif@k.u-tokyo.ac.jp
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Summary

The transition from a differentiated germ cell into a totipotent zygote during oogenesis and preimplantation development is critical to the creation of a new organism. During this period, cell characteristics change dynamically, suggesting that a global alteration of gene expression patterns occurs, which is regulated by global changes in various epigenetic factors. Among these, transcription factors (TFs) are essential in the direct regulation of transcription and also play important roles in determining cell characteristics. However, no comprehensive analysis of TFs from germ cells to embryos had been undertaken. We used mRNA amplification systems and microarrays to conduct a genomewide analysis of TFs at various stages of oogenesis and preimplantation development. The greatest alteration in TFs occurred between the 1- and 2-cell stages, at which time zygotic genome activation (ZGA) occurs. Our analysis of TFs classified by structure and function revealed several specific patterns of change. Basic transcription factors, which are the general components of transcription, increased transiently at the 2-cell stage, while homeodomain (HD) TFs were expressed specifically in the oocyte. TFs containing the Rel homology region (RHR) and Ets domains were expressed at a high level in 2-cell and blastocyst embryos. Thus, the global TF dynamics that occur during oogenesis and preimplantation development seem to regulate the transition from germ-cell-type to embryo-type gene expression.

Keywords

EmbryoGene expressionMicroarrayOocyteTranscription factor
Type
Research Articles
Information
Zygote , Volume 15 , Issue 2 , May 2007 , pp. 117 - 128
Copyright
Copyright © Cambridge University Press 2007

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