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The bone morphogenetic protein system and the regulation of ovarian follicle development in mammals

Published online by Cambridge University Press:  23 January 2015

Rodrigo O.D.S. Rossi ,
José J.N. Costa ,
Anderson W.B. Silva ,
Márcia V.A. Saraiva ,
Robert Van den Hurk  and
José R.V. Silva
Rodrigo O.D.S. Rossi
Affiliation:
Biotechnology Nucleus of Sobral – NUBIS, Federal University of Ceara, Sobral, CE, Brazil.
José J.N. Costa
Affiliation:
Biotechnology Nucleus of Sobral – NUBIS, Federal University of Ceara, Sobral, CE, Brazil.
Anderson W.B. Silva
Affiliation:
Biotechnology Nucleus of Sobral – NUBIS, Federal University of Ceara, Sobral, CE, Brazil.
Márcia V.A. Saraiva
Affiliation:
Biotechnology Nucleus of Sobral – NUBIS, Federal University of Ceara, Sobral, CE, Brazil.
Robert Van den Hurk
Affiliation:
Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.163, Utrecht, The Netherlands.
José R.V. Silva*
Affiliation:
Biotechnology Nucleus of Sobral – NUBIS, Federal University of Ceara, Av. Comandante Maurocélio Rocha Ponte 100, CEP 62041–040, Sobral, CE, Brazil.
*
All correspondence to: J.R.V. Silva. Biotechnology Nucleus of Sobral – NUBIS, Federal University of Ceara, Av. Comandante Maurocélio Rocha Ponte 100, CEP 62041–040, Sobral, CE, Brazil. Tel:/Fax: +55 88 36118000. e-mail: jrvsilva@ufc.br
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Summary

The bone morphogenetic protein (BMP) family consists of several growth factor proteins that belong to the transforming growth factor-β (TGF-β) superfamily. BMPs bind to type I and type II serine–threonine kinase receptors, and transduce signals through the Smad signalling pathway. BMPs have been identified in mammalian ovaries, and functional studies have shown that they are involved in the regulation of oogenesis and folliculogenesis. This review summarizes the role of the BMP system during formation, growth and maturation of ovarian follicles in mammals.

Keywords

Folliculogenesis, OogenesisOvaryTransforming growth factor
Type
Research Article
Information
Zygote , Volume 24 , Issue 1 , February 2016 , pp. 1 - 17
Copyright
Copyright © Cambridge University Press 2015 

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