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Comparing the IVM laboratory outcomes between stimulated IVF with unstimulated natural cycles

Published online by Cambridge University Press:  22 June 2022

Mohammad Ali Khalili Open the ORCID record for Mohammad Ali Khalili [Opens in a new window] ,
Mehdi Mohsenzadeh ,
Mojgan Karimi Zarchi  and
Mahboubeh Vatanparast Open the ORCID record for Mahboubeh Vatanparast [Opens in a new window]
Mohammad Ali Khalili
Affiliation:
Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mehdi Mohsenzadeh
Affiliation:
Gerash Al-Zahra Fertility Center, Gerash University of Medical Sciences, Gerash, Iran
Mojgan Karimi Zarchi
Affiliation:
Department of Gynecology oncology, Iran University of Medical Sciences, Tehran, Iran
Mahboubeh Vatanparast*
Affiliation:
Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
*
Author for correspondence: Mahboubeh Vatanparast. Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. E-mail: Mahboob_vatan@yahoo.com
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Summary

Recently, more attention has been raised towards fertility preservation in women with cancer. One option is in vitro maturation (IVM) of the immature oocytes as there is not enough time for induction of an ovarian stimulation protocol. The aim was to compare the IVM laboratory outcomes between stimulated and unstimulated (natural) in vitro fertilization (IVF) cycles. In total, 234 immature oocytes collected from 15 cancer patients who underwent an IVM programme (natural IVM) and 23 IVF cycles with a controlled ovarian hyperstimulation protocol (stimulated IVM) were analyzed. The oocyte morphology, zona pellucida (ZP), and meiotic spindle presence were measured using PolScope technology. Also, the rates of oocyte maturation and fertilization were assessed in both groups. The IVM rate was higher in the stimulated cycle (P < 0.05), but the fertilization rate was insignificant in comparison with unstimulated cycles. There were no significant differences in the spindle visualization and ZP birefringence scoring between the groups (P > 0.05). The oocyte normal morphology was better in the stimulated cycle compared with the natural cycle (P < 0.05). In conclusion, IVM can be recommended for cancer patients as an alternative treatment when there is insufficient time for conventional IVF before chemotherapy initiation.

Keywords

Fertility preservationFertilizationNatural cycle IVMMaturationStimulated cycle IVM
Type
Research Article
Information
Zygote , Volume 30 , Issue 5 , October 2022 , pp. 593 - 599
Copyright
© The Author(s), 2022. Published by Cambridge University Press

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