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Effect of anti-PMSG on distribution of estrogen receptor alpha and progesterone receptor in mouse ovary, oviduct and uterus

Published online by Cambridge University Press:  02 September 2014

Zi Li Lin ,
He Min Ni ,
Yun Hai Liu ,
Xi Hui Sheng ,
Xiang Shun Cui ,
Nam Hyung Kim  and
Yong Guo
Zi Li Lin
Affiliation:
Department of Animal Sciences, Chungbuk National University, Cheongju, Korea.
He Min Ni
Affiliation:
College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
Yun Hai Liu
Affiliation:
College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
Xi Hui Sheng
Affiliation:
College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
Xiang Shun Cui
Affiliation:
Department of Animal Sciences, Chungbuk National University, Cheongju, Korea.
Nam Hyung Kim
Affiliation:
Department of Animal Sciences, Chungbuk National University, Cheongju, Korea.
Yong Guo*
Affiliation:
College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
*
All correspondence to: Yong Guo. College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China. Tel: +86 10 80799133. Fax: +86 10 80799468. e-mail: y63guo@126.com
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Summary

It is well established that estrogen and progesterone are critical endogenous hormones that are essential for implantation and pregnancy in females. However, the distribution of estrogen receptor α (ERα) and progesterone receptor (PR) in female reproductive tracts is elusive. Herein, we report that after serial treatments with pregnant mare's serum gonadotrophin (PMSG) with or without anti-PMSG (AP), mice could regulate the distribution of ERα and PR in the murine ovary, oviduct and uterus and the level of estradiol in serum. ERα and PR regulation by PMSG and anti-PMSG was estrous cycle-dependent and critical for promoting the embryo-implantation period. Furthermore, our results suggested that AP-42 h treatment is more effective than the other treatments. In contrast, other treatment groups also affected the distribution of ERα and PR in mouse reproductive tracts. Thus, we found that anti-PMSG has the potential to restore the distribution of ERα and PR, which could effectively reduce the negative impact of residual estrogen caused by the normal superovulation effect of PMSG in mice.

Keywords

Anti-PMSGDistribution of ERα and PRPMSG
Type
Research Article
Information
Zygote , Volume 23 , Issue 5 , October 2015 , pp. 695 - 703
Copyright
Copyright © Cambridge University Press 2014 

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