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Expression of PCNA in the testis of the lizard, Podarcis s. sicula: an endogenous molecular marker of mitotic germinal epithelium proliferation

Published online by Cambridge University Press:  28 November 2001

Paolo Chieffi ,
Mario Nasti ,
Domenico Fulgione  and
Renato Franco
Paolo Chieffi
Affiliation:
Dipartimento di Medicina Sperimentale, ‘F. Bottazzi’, II Università di Napoli, Naples, Italy. Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli ‘Federico II’, Naples, Italy.
Mario Nasti
Affiliation:
Dipartimento di Scienze Biomorfologiche e Funzionali, Università di Napoli ‘Federico II’, Naples, Italy.
Domenico Fulgione
Affiliation:
Dipartimento di Zoologia, Università di Napoli ‘Federico II’, Naples, Italy.
Renato Franco
Affiliation:
Dipartimento di Scienze Biomorfologiche e Funzionali, Università di Napoli ‘Federico II’, Naples, Italy.
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Abstract

Proliferating cell nuclear antigen (PCNA) plays an essential role in nucleic acid metabolism as a component of the replication and repair machinery. This protein encircles DNA and can slide bidirectionally along the duplex binding to DNA polymerase δ and ε. It is well known that PCNA interacts with proteins involved in the cell cycle. The PCNA interactions with different cellular proteins and the importance of these interactions are discussed. To examine mitotic germinal epithelium proliferation during annual discontinuous spermatogenesis in the lizard Podarcis s. sicula, temporal and the spatial PCNA expression were investigated, and provide a useful endogenous molecular marker.

Keywords

Cell cycleMitosisPCNAReptilesSpermatogenesis
Type
Research Article
Information
Zygote , Volume 9 , Issue 4 , November 2001 , pp. 317 - 322
Copyright
2001 Cambridge University Press

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