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Fresh oocyte cycles yield improved embryo quality compared with frozen oocyte cycles in an egg-sharing donation programme

Published online by Cambridge University Press:  18 January 2021

Amanda Souza Setti Open the ORCID record for Amanda Souza Setti [Opens in a new window] ,
Daniela Paes de Almeida Ferreira Braga ,
Assumpto Iaconelli Jr  and
Edson Borges Jr
Amanda Souza Setti*
Affiliation:
Fertility Medical Group, Av. Brigadeiro Luis Antonio, 4545, São Paulo, SP01401-002, Brazil Sapientiae Institute – Centro de Estudos e Pesquisa em Reprodução Humana Assistida, Rua Vieira Maciel, 62 São Paulo, SP04503-040, Brazil
Daniela Paes de Almeida Ferreira Braga
Affiliation:
Fertility Medical Group, Av. Brigadeiro Luis Antonio, 4545, São Paulo, SP01401-002, Brazil Sapientiae Institute – Centro de Estudos e Pesquisa em Reprodução Humana Assistida, Rua Vieira Maciel, 62 São Paulo, SP04503-040, Brazil
Assumpto Iaconelli Jr
Affiliation:
Fertility Medical Group, Av. Brigadeiro Luis Antonio, 4545, São Paulo, SP01401-002, Brazil Sapientiae Institute – Centro de Estudos e Pesquisa em Reprodução Humana Assistida, Rua Vieira Maciel, 62 São Paulo, SP04503-040, Brazil
Edson Borges Jr
Affiliation:
Fertility Medical Group, Av. Brigadeiro Luis Antonio, 4545, São Paulo, SP01401-002, Brazil Sapientiae Institute – Centro de Estudos e Pesquisa em Reprodução Humana Assistida, Rua Vieira Maciel, 62 São Paulo, SP04503-040, Brazil
*
Author for correspondence: Amanda Setti. Av. Brigadeiro Luis Antonio, 4545, São Paulo, SP01401-002, Brazil. Tel: +55 11 3018 8181. E-mail: amanda@sapientiae.org.br
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Summary

The objective of this study was to investigate any effect of cryopreservation of donated eggs on laboratorial and clinical outcomes of intracytoplasmic sperm injection (ICSI) cycles. This retrospective cohort study included 320 oocyte recipients undergoing 307 vitrified and 119 fresh oocyte recipient ICSI cycles, participating in an egg-sharing donation programme, from 2015 to 2018, in a private university-affiliated in vitro fertilization (IVF) centre. A review of donor and recipient ICSI cycles was charted. A general mixed models fit by restricted maximum likelihood, followed by Bonferroni post hoc test was used to compare the means between fresh and warm oocyte donation groups and investigate the effect of cryopreservation on recipient ICSI outcome. The main outcome measure was blastocyst development rates. Fertilization rate, high-quality embryo rates on days 2 and 3, normal cleavage speed rates on days 2 and 3, and blastocyst development rate were significantly higher for the fresh oocyte donation cycles compared with warmed oocyte donation cycles. In the egg-sharing donation programme, fertilization and embryo developmental competence were reduced when vitrified oocytes from infertile couples were used for ICSI compared with fresh oocytes.

Keywords

CryopreservationEmbryoICSIOocyteVitrification
Type
Research Article
Information
Zygote , Volume 29 , Issue 3 , June 2021 , pp. 234 - 238
Copyright
© The Author(s), 2021. Published by Cambridge University Press

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