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Impact of body mass index on intracytoplasmic sperm injection in women with polycystic ovary syndrome

Published online by Cambridge University Press:  18 January 2021

Stanly Kamardi ,
IGN Harry Wijaya Surya ,
I Nyoman Bayu Mahendra ,
IB Putra Adnyana ,
Anom Suardika ,
Nono Tondohusodo  and
Jaqueline Sudiman Open the ORCID record for Jaqueline Sudiman [Opens in a new window]
Stanly Kamardi
Affiliation:
Obstetrics and Gynaecology Department, Faculty of Medicine, Udayana University, Denpasar-Bali, Indonesia
IGN Harry Wijaya Surya
Affiliation:
Obstetrics and Gynaecology Department, Faculty of Medicine, Udayana University, Denpasar-Bali, Indonesia
I Nyoman Bayu Mahendra
Affiliation:
Obstetrics and Gynaecology Department, Faculty of Medicine, Udayana University, Denpasar-Bali, Indonesia
IB Putra Adnyana
Affiliation:
Obstetrics and Gynaecology Department, Faculty of Medicine, Udayana University, Denpasar-Bali, Indonesia Bali Royal Hospital, Royal IVF Clinic, Denpasar-Bali, Indonesia
Anom Suardika
Affiliation:
Obstetrics and Gynaecology Department, Faculty of Medicine, Udayana University, Denpasar-Bali, Indonesia Bali Royal Hospital, Royal IVF Clinic, Denpasar-Bali, Indonesia
Nono Tondohusodo
Affiliation:
Obstetrics and Gynaecology Department, Faculty of Medicine, Udayana University, Denpasar-Bali, Indonesia Bali Royal Hospital, Royal IVF Clinic, Denpasar-Bali, Indonesia
Jaqueline Sudiman*
Affiliation:
Bali Royal Hospital, Royal IVF Clinic, Denpasar-Bali, Indonesia Anatomy Department, Faculty of Medicine, Udayana University, Denpasar-Bali, Indonesia
*
Author for correspondence: Jaqueline Sudiman. Bali Royal Hospital, Royal IVF Clinic, Denpasar-Bali, Indonesia. E-mail: j_sudiman@yahoo.com; jaqueline@unud.ac.id
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Summary

Polycystic ovary syndrome (PCOS) is a condition that affects fertility. There are two types of PCOS; the normal/lean type and overweight/obese type. The aim of this study was to assess baseline characteristics, ovarian response, quality of oocytes, embryos, pregnancy, implantation and live birth rates in normal/lean and overweight/obese patients with PCOS undergoing ICSI compared with patients without PCOS. This retrospective case–control analytical study included 38 normal/lean and 17 overweight/obese patients with PCOS, and 98 normal/lean and 17 overweight/obese patients without PCOS. Parameters were observed based on baseline characteristics, ovarian response to dosage and duration of gonadotropin administered, number of oocytes, matured oocytes, fertilization rate, embryo quality and development, pregnancy, implantation and live birth rates. Basal serum luteinizing hormone in normal/lean PCOS was significantly higher compared with non-PCOS groups. Total dosage of gonadotropin used was significantly lower in normal/lean PCOS compared with other groups. End estradiol levels in normal/lean PCOS was significantly higher compared with the non-PCOS groups. Number of follicles, retrieved oocytes and matured oocytes were significantly higher in PCOS groups compared with the non-PCOS groups. However, there were no differences in fertilized oocytes, cleavage, number of top-quality embryos, pregnancy, implantation, and live birth rates among groups. This present study suggests that normal/lean PCOS requires lower gonadotropin dosages and that patients with PCOS have more follicles and oocytes compared with patients without PCOS, however the number of fertilized oocytes and embryos from patients with PCOS were the same as those from patients without PCOS and suggested that the quality of retrieved oocytes in PCOS might be compromised.

Keywords

BMIEmbryo qualityOocyte qualityOvarian responsePolycystic ovary syndrome (PCOS)Success rates
Type
Research Article
Information
Zygote , Volume 29 , Issue 3 , June 2021 , pp. 229 - 233
Copyright
© The Author(s), 2021. Published by Cambridge University Press

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