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The KIDScore™ D3 scoring system contributes to the prediction of embryonic development potential: A promising tool for screening high-quality embryos

Published online by Cambridge University Press:  30 March 2022

Jing Zhou Open the ORCID record for Jing Zhou [Opens in a new window] ,
Rou Li ,
Jun Zhou ,
Yu-Ling Nie ,
Mei-Qing Li  and
Hong-Qing Liao
Jing Zhou
Affiliation:
The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China Hengyang Nanhua-Xinghui Reproductive Health Hospital, Hengyang, China
Rou Li
Affiliation:
The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China
Jun Zhou
Affiliation:
The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China Hengyang Nanhua-Xinghui Reproductive Health Hospital, Hengyang, China
Yu-Ling Nie
Affiliation:
Hengyang Nanhua-Xinghui Reproductive Health Hospital, Hengyang, China
Mei-Qing Li
Affiliation:
The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China Hengyang Nanhua-Xinghui Reproductive Health Hospital, Hengyang, China
Hong-Qing Liao*
Affiliation:
The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China Hengyang Nanhua-Xinghui Reproductive Health Hospital, Hengyang, China
*
Author for correspondence: Hong-Qing Liao, The Second Affiliated Hospital, Hengyang Medical School, University of South China and Hengyang Nanhua-Xinghui Reproductive Health Hospital, No. 30, Jiefang Road, Hengyang421001, Hunan Province, China. Tel: +86 18973484329. E-mail: 17175979@qq.com
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Summary

Using the KIDScoreTM D3 (KID3) scoring system, day 3 embryos observed by time-lapse imaging (TLI) were scored to explore the predictive value of the KID scoring system on the developmental potential of embryos. The kinetic parameters of 477 normal fertilized embryos from 77 patients who underwent TLI in our hospital from January 2019 to June 2020 were evaluated by KID3, and the embryos were divided into five groups according to the scores for retrospective analysis of blastocyst formation. Additionally, the high-quality blastocyst formation rate, pregnancy rate and early abortion rate were analyzed via KID3 and traditional morphological assessments, and comparisons of differences among different ages were also performed. In the KID3 estimate, the blastocyst or high-quality blastocyst formation rate in the score 5 group was markedly higher than that in the score 1–4 groups. Blastocyst or high-quality blastocyst formation rates in the A group (the results of two evaluation tools indicated they were excellent embryos) and the B group (KID3: excellent embryos, traditional evaluation: not excellent embryos) were evidently increased in comparison with the C or D group (KID3: not excellent embryos, traditional evaluation: excellent embryo or not, respectively). Furthermore, the percentages of score 5 embryos, blastocyst and high-quality blastocyst formation rates for patients ≥ 35 years old were markedly decreased compared with those for patients < 34 years old, while the trends of nondiploid cleavage, multinucleation and asymmetric division were the opposite. Collectively, the KID3 scoring system may be a promising predictive tool for screening embryos with better developmental potential.

Keywords

Blastocyst formation rateHigh-quality embryoKIDScoreTM D3Time-lapse imagingTraditional static assessment
Type
Research Article
Information
Zygote , Volume 30 , Issue 4 , August 2022 , pp. 528 - 535
Copyright
© The Author(s), 2022. Published by Cambridge University Press

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