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Restoring fertility after ovarian tissue cryopreservation: a half century of research

Published online by Cambridge University Press:  31 October 2012

Franciele Osmarini Lunardi ,
Valdevane Rocha Araújo ,
Marcelo Picinin Bernuci ,
Luciane Osmarini Lunardi ,
Raphael Fernando Braga Gonçalves ,
Adeline de Andrade Carvalho ,
José Ricardo de Figueiredo  and
Ana Paula Ribeiro Rodrigues
Franciele Osmarini Lunardi*
Affiliation:
Laboratory of Manipulation of Oocytes and Ovarian Pre-antral Follicles (LAMOFOPA), Faculty of Veterinary of Ceará State University, Fortaleza, CE, Brazil.
Valdevane Rocha Araújo
Affiliation:
Laboratory of Manipulation of Oocytes and Ovarian Pre-antral Follicles (LAMOFOPA), Veterinary Faculty of Ceará State University, Fortaleza, CE, Brazil.
Marcelo Picinin Bernuci
Affiliation:
Department of Gynecology and Obstetrics, Clinical Hospital of the Faculty of Medicine of Ribeirao Preto of Sao Paulo University, Ribeirao Preto, SP, Brazil.
Luciane Osmarini Lunardi
Affiliation:
Faculty of Biosciences of Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Raphael Fernando Braga Gonçalves
Affiliation:
Laboratory of Manipulation of Oocytes and Ovarian Pre-antral Follicles (LAMOFOPA), Veterinary Faculty of Ceará State University, Fortaleza, CE, Brazil.
Adeline de Andrade Carvalho
Affiliation:
Laboratory of Manipulation of Oocytes and Ovarian Pre-antral Follicles (LAMOFOPA), Veterinary Faculty of Ceará State University, Fortaleza, CE, Brazil.
José Ricardo de Figueiredo
Affiliation:
Laboratory of Manipulation of Oocytes and Ovarian Pre-antral Follicles (LAMOFOPA), Veterinary Faculty of Ceará State University, Fortaleza, CE, Brazil.
Ana Paula Ribeiro Rodrigues
Affiliation:
Laboratory of Manipulation of Oocytes and Ovarian Pre-antral Follicles (LAMOFOPA), Veterinary Faculty of Ceará State University, Fortaleza, CE, Brazil.
*
All correspondence to: Franciele Osmarini Lunardi. Laboratory of Manipulation of Oocytes and Ovarian Pre-antral Follicles (LAMOFOPA), Faculty of Veterinary of Ceará State University, Fortaleza, CE, Brazil. Tel: + 55 85 3101 9852. Fax: + 55 85 3101 9840. e-mail: lunardi.franciele@gmail.com
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Summary

Tissue transplantation and in vitro ovarian follicle culture have been investigated as alternative techniques to restore fertility in young women who are facing fertility-threatening diseases or treatments following ovarian tissue cryopreservation. Although transplants of fresh or frozen ovarian tissue have successfully yielded healthy live births in different species including humans, the risks of reintroducing cancer cells back into the patient, post treatment, have limited its clinical purpose. The in vitro ovarian follicle culture minimizes these risks and provides a way to harvest more mature oocytes, however its clinical translation has yet to be determined. Not only is it possible for tissue cryopreservation to safeguard fertility in cancer patients, this technique also allows the maintenance of germplasm banks for animals of high commercial value or for those animals that are at risk of extinction. Given the importance of managing female genetic material, this paper reviews the progress of the methods used to preserve and restore female fertility in different species to demonstrate the results obtained in the past 50 years of research, the current achievements and the future directions on this field.

Keywords

Fertility preservationIn vitro follicle cultureOvarian tissue transplantSlow freezingVitrification
Type
Research Article
Information
Zygote , Volume 21 , Issue 4 , November 2013 , pp. 394 - 405
Copyright
Copyright © Cambridge University Press 2012 

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