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Should fertile women quit drinking alcohol to produce better quality oocytes?

Published online by Cambridge University Press:  18 December 2020

Burcu Ozbakir  and
Pinar Tulay Open the ORCID record for Pinar Tulay [Opens in a new window]
Burcu Ozbakir
Affiliation:
Near East University, Faculty of Medicine, Department of Obstetrics and Gynecology, Nicosia, Cyprus Near East University, DESAM Institute, Nicosia, Cyprus
Pinar Tulay*
Affiliation:
Near East University, DESAM Institute, Nicosia, Cyprus Near East University, Faculty of Medicine, Department of Medical Genetics, Nicosia, Cyprus
*
Author for correspondence: Pinar Tulay. Near East University, Faculty of Medicine, Department of Medical Genetics, Near East University, Research Center of Experimental Health Sciences (DESAM), Near East Boulvard, Nicosia North, Cyprus. E-mail: pinar.tulay@neu.edu.tr
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Summary

Alcohol consumption has long been shown to affect both fetal health and pregnancy. In this study, antral follicle count, maturation level of oocytes including morphological assessment and number of metaphase I (MI), metaphase II (MII) and germinal vesicle (GV) stage oocytes obtained from young women (age < 30 years old) with or without alcohol consumption were investigated. In total, 20 healthy women who were social drinkers and 36 healthy women who do not consume alcohol were involved in this study. Women in both study and control groups were undergoing controlled ovarian stimulation. The antral follicle count and the number and quality of the oocytes retrieved were evaluated and recorded. In total, 635 antral follicles, 1098 follicles and 1014 oocytes with 820 MII, 72 MI and 78 GV stage oocytes were collected from the social drinkers. In the control group, 628 antral follicles, 1136 follicles and 1085 oocytes with 838 MII, 93 MI and 102 GV stage oocytes were evaluated. The results of this study showed that the antral follicle count was very similar in both groups. The number of oocytes and MII stage oocytes was slightly higher in the control group, although it was not a significant difference. This study showed that although the consumption of alcohol may have adverse effects post-implantation, it may not have a solid effect during oogenesis in young women. The results of this study are especially important in clinical settings as some women who are social drinkers undergo in vitro fertilization treatments.

Keywords

AlcoholIVFOocyte qualityOocyte numberYoung women
Type
Research Article
Information
Zygote , Volume 29 , Issue 2 , April 2021 , pp. 176 - 178
Copyright
© The Author(s), 2020. Published by Cambridge University Press

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