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Negative Emotion Interference During a Synonym Matching Task in Pediatric Bipolar Disorder with and without Attention Deficit Hyperactivity Disorder

Published online by Cambridge University Press:  11 February 2013

Alessandra M. Passarotti ,
Jacklynn M. Fitzgerald ,
John A. Sweeney  and
Mani N. Pavuluri
Alessandra M. Passarotti*
Affiliation:
Pediatric Brain Research and Intervention Center, University of Illinois at Chicago, Chicago, Illinois Institute for Juvenile Research, University of Illinois at Chicago, Chicago, Illinois
Jacklynn M. Fitzgerald
Affiliation:
Pediatric Brain Research and Intervention Center, University of Illinois at Chicago, Chicago, Illinois Institute for Juvenile Research, University of Illinois at Chicago, Chicago, Illinois
John A. Sweeney
Affiliation:
University of Texas Southwestern Medical Center, Dallas, Texas
Mani N. Pavuluri
Affiliation:
Pediatric Brain Research and Intervention Center, University of Illinois at Chicago, Chicago, Illinois Institute for Juvenile Research, University of Illinois at Chicago, Chicago, Illinois Colbeth Clinic, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois
*
Correspondence and reprint requests to: Alessandra M. Passarotti, Pediatric Brain Research and Intervention Center, Institute for Juvenile Research, University of Illinois at Chicago, 1747 West Roosevelt Road (M/C 747), Chicago, IL 60608. E-mail: apassarotti@psych.uic.edu
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Abstract

This study examined whether processing of emotional words impairs cognitive performance in acutely ill patients with pediatric bipolar disorder (PBD), with or without comorbid attention-deficit hyperactivity disorder (ADHD), relative to healthy controls (HC). Forty youths with PBD without ADHD, 20 youths with PBD and ADHD, and 29 HC (mean age = 12.97 ± 3.13) performed a Synonym Matching task, where they decided which of two probe words was the synonym of a target word. The three words presented on each trial all had the same emotional valence, which could be negative, positive, or neutral. Relative to HC both PBD groups exhibited worse accuracy for emotional words relative to neutral ones. This effect was greater with negative words and observed regardless of whether PBD patients had comorbid ADHD. In the PBD group without ADHD, manic symptoms correlated negatively with accuracy for negative words, and positively with reaction time (RT) for all word types. Our findings suggest a greater disruptive effect of emotional valence in both PBD groups relative to HC, reflecting the adverse effect of altered emotion processing on cognitive function in PBD. Future studies including an ADHD group will help clarify how ADHD symptoms may affect emotional interference independently of PBD. (JINS, 2013, 19, 1–12)

Keywords

BipolarADHDEmotionAttention biasInterferenceYouths
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 19 , Issue 5 , May 2013 , pp. 601 - 612
Copyright
Copyright © The International Neuropsychological Society 2013

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