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Accepted manuscript

Associations between inflammation–related dietary patterns and obesity: A cohort study among Tibetan adults

Published online by Cambridge University Press:  24 January 2025

Xiaomin Sun Open the ORCID record for Xiaomin Sun [Opens in a new window] ,
Wenxiu Jian ,
Xiao Tang ,
Rui Li ,
Bin Zhang ,
Yingxin Chen ,
Haijing Wang ,
Lei Zhao ,
Yangrui Zhang  and
Tanisawa Kumpei
...Show all authors
Xiaomin Sun
Affiliation:
International Obesity and Metabolic Disease Research Center, Global Health Institute, School of Public Health, Xi’an Jiaotong University, Xi’an 710061, China
Wenxiu Jian
Affiliation:
Department of Public Health, Qinghai University Medical College, Xining 810016, China
Xiao Tang
Affiliation:
Department of Public Health, Qinghai University Medical College, Xining 810016, China
Rui Li
Affiliation:
International Obesity and Metabolic Disease Research Center, Global Health Institute, School of Public Health, Xi’an Jiaotong University, Xi’an 710061, China
Bin Zhang
Affiliation:
School of Mathematics and Statistics, Qinghai Minzu University, Xining 810007, China
Yingxin Chen
Affiliation:
International Obesity and Metabolic Disease Research Center, Global Health Institute, School of Public Health, Xi’an Jiaotong University, Xi’an 710061, China
Haijing Wang
Affiliation:
Department of Public Health, Qinghai University Medical College, Xining 810016, China
Lei Zhao
Affiliation:
Department of Public Health, Qinghai University Medical College, Xining 810016, China
Yangrui Zhang
Affiliation:
Department of Public Health, Qinghai University Medical College, Xining 810016, China
Tanisawa Kumpei
Affiliation:
Faculty of Sport Sciences, Waseda University, Saitama 359-1192, Japan
Zumin Shi
Affiliation:
Human Nutrition Department, College of Health Sciences, QU Health, Qatar University, Doha 2713, Qatar
Youfa Wang*
Affiliation:
International Obesity and Metabolic Disease Research Center, Global Health Institute, School of Public Health, Xi’an Jiaotong University, Xi’an 710061, China
Wen Peng*
Affiliation:
Department of Public Health, Qinghai University Medical College, Xining 810016, China Qinghai Provincial Key Laboratory of Prevention and Control of Glucolipid Metabolic Diseases with Traditional Chinese Medicine, Xining 810016, China
*
#Corresponding authors: Youfa Wang, MD, MS, PhD, FTOS, Vice Director, Health Science Center, Dean, Global Health Institute, University Distinguished Professor, Professor, School of Public Health, Xi’an Jiaotong University, West China Science and Technology Innovation Harbour (iHarbour), Xi’an, Shaanxi, 710061, China, Email: youfawang@gmail.com, Tel: +86-29-88967396; Wen Peng, MD, MPH, Professor and Director, Nutrition and Health Promotion Center, Department of Public Health, Medical College, Qinghai University, No. 16 Kunlun Road, Xining, 810000, China, Email: wen.peng2014@foxmail.com, Tel: +86-971-6104093
#Corresponding authors: Youfa Wang, MD, MS, PhD, FTOS, Vice Director, Health Science Center, Dean, Global Health Institute, University Distinguished Professor, Professor, School of Public Health, Xi’an Jiaotong University, West China Science and Technology Innovation Harbour (iHarbour), Xi’an, Shaanxi, 710061, China, Email: youfawang@gmail.com, Tel: +86-29-88967396; Wen Peng, MD, MPH, Professor and Director, Nutrition and Health Promotion Center, Department of Public Health, Medical College, Qinghai University, No. 16 Kunlun Road, Xining, 810000, China, Email: wen.peng2014@foxmail.com, Tel: +86-971-6104093
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Abstract

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Substantial changes resulting from the interaction of environmental and dietary factors contribute to an increased risk of obesity, while their specific associations with obesity remain unclear. Identify inflammation-related dietary patterns (DPs) and explore their associations with obesity among urbanized Tibetan adults under significant environmental and dietary changes.Totally, 1826 subjects from the suburbs of Golmud City were enrolled in an open cohort study, of which 514 were followed up. Height, weight, and waist circumference were used to define overweight and obesity. DPs were derived using reduced rank regression with 41 food groups as predictors and hs-CRP and prognostic nutritional index as inflammatory response variables. Altitude was classified as high or ultra-high. Two DPs were extracted. DP-1 was characterized by having high consumptions of sugar-sweetened beverages, savory snacks, and poultry, and a low intake of tsamba. DP-2 had high intakes of poultry, pork, animal offal, and fruits, and a low intake of butter tea. Participants in the highest tertiles (T3) of DPs had increased risks of overweight and obesity (DP-1: OR=1.37, 95% CI: 1.07, 1.77; DP-2: OR=1.48, 95% CI: 1.18, 1.85) than those in the lowest tertiles (T1). Participants in T3 of DP-2 had an increased risk of central obesity (OR=2.25, 95% CI: 1.49, 3.39) than those in T1. The positive association of DP-1 with overweight and obesity was only significant at high altitudes, while no similar effect was observed for DP-2. Inflammation-related DPs were associated with increased risks of overweight and/or obesity.

Keywords

inflammatory-related dietary patternsreduced rank regressionoverweightobesityTibetan Plateau
Type
Research Article
Information
British Journal of Nutrition , Accepted manuscript , pp. 1 - 26
Copyright
The Author(s), 2025. Published by Cambridge University Press on behalf of The Nutrition Society

Footnotes

*

Equal contributions

†

Senior author contributed equally as corresponding authors