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Resting-state network analysis of suicide attempt history in the UK Biobank

Published online by Cambridge University Press:  31 May 2023

Matthew F. Thompson Open the ORCID record for Matthew F. Thompson [Opens in a new window] ,
Marjan Ghahramanlou-Holloway Open the ORCID record for Marjan Ghahramanlou-Holloway [Opens in a new window] ,
Mikela A. Murphy Open the ORCID record for Mikela A. Murphy [Opens in a new window] ,
Kanchana U. Perera Open the ORCID record for Kanchana U. Perera [Opens in a new window] ,
Chelsie Benca-Bachman Open the ORCID record for Chelsie Benca-Bachman [Opens in a new window] ,
Rohan H. C. Palmer Open the ORCID record for Rohan H. C. Palmer [Opens in a new window]  and
Joshua C. Gray Open the ORCID record for Joshua C. Gray [Opens in a new window]
Matthew F. Thompson*
Affiliation:
Department of Medical & Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA
Marjan Ghahramanlou-Holloway
Affiliation:
Department of Medical & Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Mikela A. Murphy
Affiliation:
Department of Medical & Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA Department of Psychology, Fordham University, New York, NY, USA
Kanchana U. Perera
Affiliation:
Department of Medical & Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Chelsie Benca-Bachman
Affiliation:
Behavioral Genetics of Addiction Laboratory, Department of Psychology, Emory University, Atlanta, GA, USA
Rohan H. C. Palmer
Affiliation:
Behavioral Genetics of Addiction Laboratory, Department of Psychology, Emory University, Atlanta, GA, USA
Joshua C. Gray
Affiliation:
Department of Medical & Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
*
Corresponding author: Matthew F. Thompson; Email: Matthew.Thompson.ctr@usuhs.edu
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Abstract

Background

Prior research has identified altered brain structure and function in individuals at risk for self-directed violence thoughts and behaviors. However, these studies have largely utilized healthy controls and findings have been inconsistent. Thus, this study examined differences in resting-state functional network connectivity among individuals with lifetime suicide attempt(s) v. lifetime self-directed violence thoughts alone.

Methods

Using data from the UK Biobank, this study utilized a series of linear regressions to compare individuals with lifetime suicide attempt(s) (n = 566) v. lifetime self-directed violence thoughts alone (n = 3447) on within- and between- network resting-state functional connectivity subnetworks.

Results

There were no significant between-group differences for between-network, within-network, or whole-brain functional connectivity after adjusting for age, sex, ethnicity, and body mass index and performing statistical corrections for multiple comparisons. Resting-state network measures may not differentiate between individuals with lifetime suicide attempt(s) and lifetime self-directed violence thoughts alone.

Conclusions

Null findings diverge from results reported in smaller neuroimaging studies of suicide risk, but are consistent with null findings in other large-scale studies and meta-analyses. Strengths of the study include its large sample size and stringent control group. Future research on a wider array of imaging, genetic, and psychosocial risk factors can clarify relative contributions of individual and combined variables to suicide risk and inform scientific understanding of ideation-to-action framework.

Keywords

fMRIresting-stateself-directed violencesuicideUK Biobank
Type
Original Article
Information
Psychological Medicine , Volume 53 , Issue 16 , December 2023 , pp. 7591 - 7600
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Copyright
Copyright © Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., 2023. Published by Cambridge University Press

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