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Ethical Solutions to the Problem of Organ Shortage

Published online by Cambridge University Press:  28 July 2022

Aksel Braanen Sterri*
Affiliation:
The Oxford Uehiro Centre for Practical Ethics, University of Oxford, Oxford, UK Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway
Sadie Regmi
Affiliation:
Ethox Centre, University of Oxford, Oxford, UK
John Harris
Affiliation:
University of Manchester, Manchester, UK Centre of Medical Law and Ethics, Kings College London and Distinguished Research Fellow, Faculty of Philosophy, Oxford Uehiro Centre for Practical Ethics, University of Oxford, Oxford, UK
*
*Corresponding author. Email: sterri@philosophy.ox.ac.uk
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Abstract

Organ shortage is a major survival issue for millions of people worldwide. Globally 1.2 million people die each year from kidney failure. In this paper, we critically examine and find lacking extant proposals for increasing organ supply, such as opting in and opt out for deceased donor organs, and parochial altruism and paired kidney exchange for live organs. We defend two ethical solutions to the problem of organ shortage. One is to make deceased donor organs automatically available for transplant without requiring consent from the donor or their relatives. The other is for society to buy nonvital organs in a strictly regulated market and provide them to people in need for free.

Type
Research Article
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press

The Problem of Organ Shortage

Globally, 1.2 million people die each year from kidney failure.Footnote 1 In the United States, over 100,000 people are on the waiting list to receive an organ.Footnote 2 While waiting, almost 10,000 people either die or are considered too sick to receive a kidney transplant each year.Footnote 3 In Europe, over 150,000 people are on the waiting list to receive an organ and 21 patients die each day waiting for a transplant.Footnote 4 In low- and middle-income countries, the problems are much worse. In India, more than 150,000 patients need dialysis each year and only 1 percent ever receive treatment,Footnote 5 and 160,000 patients are waiting for transplants but only 12,000 organs are available.Footnote 6

How can we stem the massive loss of life and the human misery that this represents? There are roughly three ways to deal with the problem of organ failure. One is to prevent organs from failing in the first place, e.g., by combatting the growing obesity epidemic that is a leading cause of kidney failure. The second is to invent and implement better treatments for organ failure. Dialysis, which is used to treat kidney failure, is very expensive and patients on dialysis only have a 35 percent survival rate five years after the onset of treatment.Footnote 7 The third is to increase the supply of organs available for transplant. This can be done through the production of non-human organs (artificial or from non-human animals), the use of more deceased donor organs, and more donations from human living hosts.

In this paper, we will leave aside prevention, early treatment, and non-human organs, and focus on ways to increase the supply of human organs.Footnote 8 We will argue in favor of the automatic availability of all deceased donor organs and a regulated market in live organs.

In Section “Deceased organ donation: opt-in, opt-out, and mandated choice,” we will discuss the two main competing models for increasing deceased donor donation in the world today, the opt-in and opt-out system, and a third contender, mandated choice. In Section “Deceased donor organs should be automatically available,” we will present an alternative model, the automatic availability of deceased donor organs. In Section “The right to decide the fate of one’s organs after one’s death,” we will deal with a pressing objection to the automatic availability model, that people should decide how their bodies are used after their death. In Section “Live organ donation,” we will examine ways to increase the supply of live organs. We will discuss the prevailing model for procuring live organs in most states, which we call the model of “parochial altruism.” We also discuss recent developments such as “paired kidney exchange” and the “advanced donation program,” that are in place in a few jurisdictions. In Section “An ethical market in live organs,” we defend our favored approach, a regulated market in live organs where the state is the sole buyer of organs and organs are allocated according to the need, not the ability to pay. In Section “Objections to a market in live organs,” we deal with objections from both opponents and proponents of markets in organs.

Deceased Organ Donation: Opt-in, Opt-out, and Mandated Choice

What would a fair public policy on deceased donor donation look like? We will argue for the automatic availability of deceased donor organs. But let us first examine the three main alternatives, the opt-in system, the opt-out system, and mandated choice.

Most countries have an opt-in system, where people must explicitly declare their willingness to become donors through donor cards or the like. A problem with the opt-in system is that most people do not sign up to become a donor, sometimes for no other reason than that they never got around to it.Footnote 9 This leaves the relatives with the decision of whether to allow the organs to be made available for transplant.

To increase the number of donors, several countries, such as Spain, Austria, Belgium, Argentina, Wales, Scotland, and England, have therefore moved to an opt-out system, where the deceased donor organs are made available for transplantation unless the donor explicitly registers their objection prior to death. The opt-out system is therefore sometimes called “presumed consent.”

A third option is mandated choice, where people are legally obliged to choose to be a donor or not, e.g., when applying for a driver’s license or other official documentation.Footnote 10 The mandated choice is implemented in New Zealand and several states in the United States.Footnote 11 Proponents argue it is better than opt-out systems because it respects rather than presumes consent and that it solves the problem of inertia that plagues opt-in systems. However, whether it increases the number of donors is heavily context dependent. If people are asked about whether they want to donate an organ when queuing for a driver’s license, they may say no merely to avoid being forced into doing something they have not properly considered, not because they are against deceased organ donation.Footnote 12 When Chile implemented a mandated choice system in 2010, it led to a 29 percent decrease in the deceased donor rates the following year.Footnote 13 The reason may have been that people were severely misinformed about the system, including that only rich people would receive kidneys.Footnote 14

The primary reason to prefer opt out to opt in is to increase the supply of donors. However, proponents often point to another beneficial feature, that opt out better reflects the will of the donor. According to this view, people want to donate their deceased donor organs, but they nevertheless fail to sign up as donors. This view finds support in the substantial discrepancy in many countries between (the relatively low) number of people who sign up to become donors and the (much higher) number who in surveys report they want to donate their organs. Pointing to this discrepancy, David Price concludes that “presumed consent regimes apparently better reflect most individuals’ true wishes as to the use of their organs in jurisdictions such as these.”Footnote 15 Furthermore, since the people who want to take their organs to their grave can ensure that by opting out of the system, there is no violation of anyone’s presumed right to decide whether to be a donor or not.

The deceased’s relatives also play an important role in the opt-out system. On paper, there are two different opt-out systems, one “soft,” where the family can veto the presumed consent, and a “hard” system, where relatives have no say in the matter. In practice, however, even in countries with “hard” opt out, practitioners often consult the family and let their decision take precedence over the presumed consent of the deceased.Footnote 16

Although more deceased donor organs are donated in countries with opt out than opt in, critics of the opt-out system argue that moving to an opt-out system does not lead to a sustained increase in the supply of organs. They claim the apparent differences in donor rates are due to differences in mortality rates between countries and other measures taken by the countries that have adopted opt-out systems.Footnote 17 In addition, if we account for the reduction in people who want to donate live organs when an opt-out system is in place,Footnote 18 they claim the total effects on the supply of organs are negligible.Footnote 19

Despite these criticisms, the most methodologically rigorous studies find a robust positive effect of out-opt systems on the supply of donors, even accounting for any reduction in the live organs that are donated.Footnote 20 There is, moreover, no indication that citizens in countries with opt-out systems react negatively to the presumptuous nature of the system. On the contrary, people have a higher willingness to donate their own deceased organs and to allow the procurement of their family members’ organs in countries with opt-out systems than opt-in systems.Footnote 21

Although the opt-out system is an improvement over opt-in and mandated choice, they share a fundamental flaw. In both systems, respecting peoples’ say over their bodies and their families’ bodies after their death takes primacy over increasing the supply of organs. Even in the best of systems, this leads to a shortage of organs. Spain, which implemented a soft opt-out system in 1979, is the country with the highest transplant rates for deceased donor organs in Europe.Footnote 22 But not even Spain is able to meet the demand for organs.Footnote 23 In 2021, approximately 7400 people are on the waiting list to receive a kidney, 1800 are waiting for a liver, and in 2019, 47 patients died while waiting for a new liver.Footnote 24 Chronic kidney disease is a leading cause of death in Spain, and one of the fastest-growing causes according to the 2016 Global Burden of Disease study.Footnote 25

People’s preferences are inappropriate as a “gate-keeper” for deceased donor donations. The proponents of an opt-out system implicitly or explicitly admit as much. They have already dispensed altogether with the notion of consent and preferences since the “presumption” is, well…presumptuous!Footnote 26

Deceased Donor Organs Should be Automatically Available

The automatic availability of deceased donor organs, also known as the routine recovery of deceased donor organs, entails organs that are automatically made available for transplant.Footnote 27 Neither relatives nor the donor of the organs needs to be consulted about their disposal. This would have several benefits. It would maximize the number of available deceased donor organs. This satisfies a crucial public responsibility, that is, providing people who suffer from organ failure with the best and most efficient treatment available. Furthermore, the automatic availability of organs would remove the need to place the burden of having to decide whether the organs should be donated or not on relatives in a distressing moment.Footnote 28

There are several moral and political principles that support the automatic availability of deceased donor organs. Giving one’s organs after death with the possible consequence of saving someone’s life is arguably within one’s duty of beneficence.Footnote 29 If morality demands anything, it demands that we make a very small sacrifice for the significant benefit of others.Footnote 30 Moreover, when the state is required to effectively coordinate the fulfillment of our moral obligations, it is arguably justified in imposing coercive measures to facilitate the effective fulfillment of these obligations.Footnote 31

The automatic availability of deceased donor organs is also a rational insurance policy for the living. We all face the risk that we may one day need a transplant ourselves. Participating in a system that takes organs from the dead to give to the living, increases one’s likelihood of living a longer and better life at a negligible cost to oneself. The automatic availability of deceased donor organs should therefore be endorsed by contractarians and contractualists, who argue we should abide by the principles it is rational (or reasonable) for people to agree to.Footnote 32

Are there nevertheless overriding objections to the proposal? One objection is often raised, that people have a right to decide what happens to their organs after their death.Footnote 33

The Right to Decide the Fate of One’s Organs After One’s Death

It is better for others if our deceased donor organs are made available after our death. Nevertheless, we are not obliged to always do what is best for others. Indeed, often we have a right to act in ways that are contrary to the interest of others. Although it is better for people who suffer from chronic kidney failure if the healthy donate one of their kidneys while living, most people believe the healthy have a right to keep their kidneys.Footnote 34 Do people have a similar right to choose not to donate their organs after their death?

There are two main theories of rights: the choice theory and the interest theory.Footnote 35 Rights, according to the choice theory serve to protect the autonomy or self-determination of the right holder. In H. L. A. Hart’s words, the choice theory makes the right holder “a small scale sovereign.”Footnote 36 In short, rights protect our power to decide what other people can do with our bodies.

According to the interest theory, rights do not primarily function to protect our ability to choose but to serve the right holders’ interests or their well-being broadly construed. If a person has a sufficiently strong well-being interest, that grounds a duty on others to respect, protect or even promote that interest.

The question is thus whether people have a right to choose what to do with their deceased donor organs, grounded in either the choice theory or the interest theory. Let us consider each theory in turn. One may think that the dead are harmed if their organs are harvested against their wishes, and that we, therefore, have a right on the interest theory to veto the harvesting of our organs.Footnote 37 However, according to Joseph Raz, there are two conditions for having a right. One needs to be the sort of entity that can have rights, and one’s well-being needs to be “a sufficient reason for holding some other person(s) to be under a duty.”Footnote 38 Although we have a strong interest in protecting our bodily integrity while living, we do not have interests that survive death. A precondition for there to be any interests at all is that there is someone for whom something matters.Footnote 39

Intuitively, it seems more plausible that the choice theory can ground a right to choose what should be done with one’s deceased donor organs after death. This is manifest in the argument that consent—from the deceased, or failing that, the surrogate consent of their next of kin or guardians—is necessary for the removal of organs from the deceased. However, consent does not serve the same function for the dead as the living. Consent normally serves to protect and facilitate autonomy and protect bodily integrity.Footnote 40 But the dead cannot make choices, they have no autonomy that can be protected or facilitated. Nor can their bodily integrity be violated. What matters for bodily integrity is not the mere interference with our bodies but that it happens against our consent. But since consent is meaningless when we are dead, so is the bodily integrity of the dead.

Even if we deny posthumous rights, could we not say that the living can have rights that extend to what happens after their death? The living certainly has interests and our interests as living beings extend to events that happen after our death. Many of the activities we pursue would lose their meaning if it were not for their place in projects that extend past our lifetime.Footnote 41 We also allow the living to make contractually binding agreements about how their wealth should be handled after their death, and these agreements cannot be violated just because the person is dead. Similarly, could we not say that people could make legally binding agreements about how their bodies can be used after their death?

However, we should not conflate legal and social conventions with moral rights. Bearing in mind that, as Shakespeare incontrovertibly observed, the dead are both beyond caring, and beyond our capacity to hurt or injure them. In Macbeth, Shakespeare observes dispassionately:

Duncan is in his grave;

After life’s fitful fever he sleeps well;

Treason has done his worst: nor steel, nor poison,

Malice domestic, foreign levy, nothing,

Can touch him further.Footnote 42

We rightly respect the will of the dead, but only to the extent that to do so is necessary to respect the vital interests and moral claims of the living. We thus need to ask what values and morally acceptable purpose it serves to allow a dead hand to reach from the grave and deny sick people the use of their deceased donor organs when to do so cannot harm them or serve any morally defensible purpose.Footnote 43

It is worth recalling that in most countries and jurisdictions a dead body must be “disposed of” in certain agreed ways: normally burial, entombment, or cremation, but sometimes embalming or cryopreservation. The human body cannot for long remain “intact” after death. As Shakespeare’s Hamlet makes clear when talking of this process:

…Your worm is your only

emperor for diet: we fat all creatures else to fat us. And we fat ourselves for maggots: your fat king and your lean beggar is but variable service; two dishes to one table: that’s the end.Footnote 44

Disintegration of the body is the only real alternative to making deceased donor organs available for others. Automatic availability of organs will only entail that some parts of the body get to serve their function a little bit longer before they meet their inevitable fate. Thus, to give the living a right over how to dispose of their entire body, deceased donor organs included, serves no valuable function.

Even if it is in the interest of the living to have a say in what is being done to “their” bodies after their death, there is a further question about what weight we should put on this interest when it conflicts with other valuable ends. Recall Raz’s second condition for having a right, that one’s interest is “a sufficient reason for holding some other person(s) to be under a duty.” There are ample examples where the interests of the community take precedence over what are people’s rights. Examples are control of road traffic, quarantine for communicable disease, detention under mental health acts, safety guidelines for certain professional activities of HIV-positive people, and compulsory attendance for jury service at criminal trials.Footnote 45 If we sometimes can put the interests of the community over the autonomy and interests of the living, we should certainly do so when the “cost” is borne by the dead.

Of course, families that want to resist the compulsory taking of deceased donor organs may be distressed at the idea of the automatic availability of organs. These are people who do have rights and interests. However, we would fail to weigh the interests of the living properly, if we gave precedence to the interests of the bereaved over those who stand to lose their life from the shortage of organs, and indeed that of other families who may have to suffer grief prematurely as a result.Footnote 46

Live Organ Donation

To make deceased donor organs automatically available would get us a long way to solving the problem of organ shortage. However, it is not sufficient. In an analysis of the United States, Philip J. Cook and Kimberly D. Krawieck estimate that “even a perfect deceased-organ consent-and-allocation system would have yielded only about 5500 kidneys in 2011, not nearly enough to cover the roughly 21,000 kidneys that are needed per year to satisfy unmet demand.”Footnote 47 Furthermore, many people who die are elderly, and their organs last for a shorter period than organs from live donors. Particularly young people can live longer and better if they receive younger organs.Footnote 48 There is also a concern that an increased number of deceased donors will reduce the number of people who are willing to be live donors. If true, we have an additional reason for finding more effective ways to increase the supply of living organs than we currently have.Footnote 49

We are not suggesting that people should sacrifice their vital organs. It is primarily non-vital organs, such as kidneys and livers, that are in short supply. Most donors live perfectly healthy lives after donating an organ. But there is a small risk involved in the procedure and its immediate after-effects. For kidney donations, the mortality rate is 3 in 10,000, and the morbidity rate is 10 percent.Footnote 50 However, the complications are minor in most cases where there are any at all.Footnote 51

How do we get enough healthy people to accept a relatively small cost to themselves for the substantial benefit of those in need of an organ? There are several levers we could pull to get more people to donate. One is to provide better information about the costs and benefits of donation. People may not donate organs because they are misinformed, or they do not realize that someone they care about needs a transplant. A study suggests that one of the biggest barriers to live organ transplants is that the person in need does not know how to ask someone to be a donor.Footnote 52 There could also be an attempt to reduce the cost to donors (by making the procedure safer or guaranteeing follow-up treatment) and increase the benefits to the donor and recipient.

To frame organ donations as generous acts of altruism expected by loved ones is one way to increase the benefit to the donor. It facilitates praise by the community and gives the donors security in the conviction that they did the right thing. It also increases the cost of not donating. To frame donations as an extraordinary gift of life is the main mechanism currently in place for making organ donation a more attractive option for prospective donors. As Kieran Healy and Kimberly Krawieck show, this framing is not a spontaneous phenomenon. To convince a hesitant public “transplant professionals worked to reclassify a transaction once viewed as a ghoulish violation of nature and God’s will into a valued and selfless “gift of life” that emphasizes both the satisfaction derived from charitable giving and the social and moral obligations owed to our neighbors.”Footnote 53 Prohibition on monetary incentives, compensation, and payment is often considered necessary to support this framing.Footnote 54

However, this system of “parochial altruism” has several problems.Footnote 55 Many people cannot find a willing donor and there are systematic differences in which groups receive a transplant and which do not. In Western countries, rich white people with high education have a much higher likelihood of finding a matching donor than others.Footnote 56 In the United States, despite an equal number of white and black patients on the waiting list for kidneys from live donors, 65 percent of recipients are white, and 12.5 percent are Black.Footnote 57

The failure to meet the need for organs is partly a creation of “parochial altruism.” Even if everyone can find a willing donor, one-third do not match their intended recipient due to “immune-system and blood-type incompatibility.”Footnote 58 Suppose Ada needs a transplant and has a non-matching donor Harry, and Hortense needs a transplant and has a non-matching donor Ali. If Ada and Ali are a match and Hortense and Harry are a match, Ada and Hortense could both receive a kidney if Harry and Ali were willing to donate to the other. However, if everyone insists on donating to their loved one, the people in need do not receive the matching kidney. The system of “parochial altruism” thus gives rise to a matching problem.

The economist Alvin Roth and colleagues have developed an ingenious solution to this matching problem: the paired kidney exchange, which is in place in the United States and some countries in Europe.Footnote 59 The system organizes a kidney exchange between non-matching donors, such as Ada and Harry and Hortense and Ali. The paired kidney exchanges have been extended to include more pairs in long chains, as well as non-simultaneous matches. Furthermore, Roth and colleagues have proposed global kidney chains to further utilize the power of matching.Footnote 60 The latest extension of the paired kidney exchange system is the Advanced Donation Program, currently in place in the United States. In the Advanced Donation program, donors can donate a kidney now in exchange for a gift certificate that can be cashed in later.Footnote 61

These innovations have saved many lives. Unfortunately, they are unable to meet the demand for kidneys. The most pressing problem is that participation in the paired kidney exchange depends on having a donor that is willing to swap their kidney with others. Thus, despite the introduction of a paired kidney exchange, thousands of people still die while waiting for new organs.

Before we present our favored proposal, a regulated market in organs, it is worth asking whether we should use a more heavy-handed approach to increase the number of organ donors. We argued above that we have an obligation to give our organs after our death to people who need them and that the government is justified in enforcing this obligation without the consent of either the deceased or their relatives. Could we not say the same about live organs? Since most of us can live perfectly healthy lives after a kidney or liver donation, we might have a duty to donate non-vital organs to the sick. And the government should enforce the fulfillment of our obligations, in the same way, they enforce our obligations to pay taxes.Footnote 62

However, there are several reasons not to favor such a proposal. One is that it is difficult to see how the government could enforce such a duty without implementing a draconian system that violates people’s basic rights. We could also question whether we have such obligations given the substantial cost involved in organ donation. Even if we have obligations to donate our non-vital organs to the living, the best system for doing so in a fair and efficient way is not a heavy-handed enforced donation. As we will go on to describe, regulated markets in organs allow for a flexible and fair way to allocate the burdens of fulfilling our obligations to people in need of organs.Footnote 63

An Ethical Market in Live Organs

The developments discussed in the previous section raise the following question: Why do we not more fully utilize the power of the market to increase the supply of organs?

The paired kidney exchange is what economists call a barter market. While no money is changing hands, kidneys are traded for other kidneys in a system that is geared to preserve the veneer of non-commodification. The point of the paired kidney exchange is to get some of the force of markets without threatening the parochial altruism that the system supposedly relies on. The market logic is all the clearer in the Advanced Donation Program, which even relies on contracts that legally bind the parties to the agreement.Footnote 64 Although these quasi-market innovations have saved many lives, it is unlikely that one will attract enough donors if one does not take one step further and pay the people who supply the organs.

There are of course several concerns that arise if one uses markets to meet the demand for kidneys. Perhaps the most important is that the poor will not be able to afford organs, people who are desperate to pay their bills will drive down the price of organs in a race to the bottom, and global wealth differences will effectively make inhabitants of low-income countries into organ pools for inhabitants in high-income countries.

To avoid these concerns, we propose a strictly regulated market in live donor organs and tissue.Footnote 65 The market would be confined to a nation state or a union of countries, such as the European Union. Only residents within the country or union can sell and receive organs. The government, through a relevant agency such as the National Health Service in the UK, will be the only buyer and organs will be allocated according to need, not ability to pay. No purchases will be allowed outside the system and all the organs will be tested for HIV and other diseases.

Sellers of organs would in turn know they had contributed to saving a life and would be reasonably compensated for their time and the risk to their health. Prices would have to be high enough to attract people into the marketplace and to ensure a fair distribution of burdens between those who contribute to treatment by paying taxes and those who contribute in kind. One reasonable estimate for a fair kidney price in the U.S. context, proposed by Luke Semrau, is $100,000.Footnote 66 The price would of course have to vary with the income level of each jurisdiction.

In countries that fund dialysis for people who suffer from kidney failure, the program will fund itself through the massive savings on dialysis and other types of care that follow in its wake. In the United States, taxpayers spend $34 billion on dialysis.Footnote 67 It is estimated that every transplant saves taxpayers $1.3 million. Another $1.3 million can be gained when recipients can return to work and other beneficial activities.Footnote 68 An analysis by the UK’s National Health System from 2009, estimated that the 23,000 people with a functioning kidney transplant saved the taxpayers £512 million and that one could expect £152 million in further savings if all 6,920 patients waiting for a transplant received a transplant.Footnote 69

Objections to a Market in Live Organs

Several objections have been raised against markets in organs, including a regulated market such as the one we propose here. Many of them concern the crowding out of parochial altruism, which we have seen is a core feature of the current system.

One concern is that the seller will no longer be motivated by altruism. If we pay people for their organs, more people would be willing to donate an organ to a stranger and if the need is satisfied by others, fewer family members will feel the pressure to donate an organ to a loved one. In Iran, the only country that has implemented a regulated market for kidneys, it is predominantly strangers who sell organs.Footnote 70 We should thus expect a loss of donations that are done from parochial altruism.

However, there is no reason to think that altruism in the morally relevant sense would be diminished by sale. First, there may be many reasons why people sell an organ. A father who sells a kidney to better care for his child does so for altruistic reasons, at least to the same extent as a father who donates a kidney to save their child.Footnote 71 Neither should we conflate sacrifices with goodness. It is better if someone who donates a kidney is compensated in return. It produces the same good results without exploiting the desperation of relatives. Although there is less of a net sacrifice and a corresponding loss in praiseworthy acts, we should not hold that against the regulated market. We do not after all regard medicine as any less a caring profession because doctors are paid.

Indeed, we can say something stronger. Society may even owe donors compensation for their sacrifice. Organ donors provide a crucial ingredient in what is the best treatment for organ failure. To the extent, we consider it a public responsibility to treat people for this, we should fairly compensate the people who play a central role in providing this treatment. It would arguably be wrong not to pay the health care personnel involved in the transplant. It is similarly wrong not to compensate donors.Footnote 72

Some have argued that it could be degrading and demeaning to pay kidney donors. Given that many people believe that the donors are making an extraordinary sacrifice, a payment may not fully communicate the true value of the donation.Footnote 73 Although this may be true, it is not an argument against a regulated market. It rather suggests that one should do more than just hand over the money to praise the donors. One way to do this is to combine payment with a public ceremony where donors receive a prize, not merely monetary compensation.Footnote 74 This is merely one possible way to communicate the extraordinary value of donations to overcome concerns about degrading the true value of organ donations. Prohibiting payment, on the contrary, does nothing to communicate the societal appreciation of the act.

Although most objections to a regulated market come from people who oppose markets altogether, one can also raise an objection from the opposite side. Why limit the market to a nation-state or a union of countries? There are many people in the world who would appreciate the option to sell an organ for much less than $100,000. Our suggestion may thus be understood as a form of protectionism or national chauvinism in need of justification. Janet Radcliffe Richards has raised this objection. She writes:

If it is presumptively bad to prevent sales altogether, because lives will be lost and adults deprived of an option some would choose if they could, it is for the same reason presumptively bad to restrict the selling of organs. Once you recognise that the default presumption is in favour of any such transaction, you should be reluctant to prevent any more sales than necessary.Footnote 75

We admit that there are benefits to a global market that gives everyone a chance to sell an organ to improve their life. There are nevertheless several reasons to favor a regulated and nation-bound market. One is that it provides better control over the conditions under which people sell their organs, which makes it easier to avoid exploitation and undue pressure from creditors, family, and the like. The second is that it makes it possible to communicate what many take to be the true value of the act. The third is that it is very unlikely that citizens will favor a global market in organs making it unacceptable in democracies. A global market in organs is thus worse than a regulated market because it satisfies fewer of the relevant moral criteria of a successful policy proposal.

Conclusion

We have argued in favor of the automatic availability of deceased donor organs and a regulated market for live organs. These measures should make good the lethal shortfall in donor organs in an ethical way that would not bring anything but credit to a decent and caring society.

The proposals we have put forward could be said to fail to secure support from the populace. Whether the arguments in favor of automatic availability of organs and an ethical market in live organs would fail to convince people is partly an empirical question, but it is an important one. In addition to a program of public involvement, education, and information to develop and make the case for these proposals, caution will have to be exercised before steps are taken toward pursuing these as policy options. However, we believe people over time will see the virtue of solving the problem of organ shortage in the rational and ethical way put forth in this paper. We hope, moreover, that the suggestions we propose will occasion a more constructive discussion of proposals for how to reform a system that is in vital need of change.

Acknowledgements

We are grateful to Andreas Albertsen for helpful comments on the article. Work on this article was supported by funding from Research Council of Norway, project 315957.

References

Notes

1. GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: A systematic analysis for the global burden of disease study 2015. Lancet 2016;388(10053):1459–544.

2. Organ Procurement and Transplantation Network. National Data; available at https://optn.transplant.hrsa.gov/data/view-data-reports/national-data/# (last accessed 12 Dec 2021).

3. OPTN/SRTR. OPTN/SRTR 2017 Annual Data Report: Kidney. Organ Procurement and Transplantation Network and Scientific Registry of Transplant Recipients 2017; available at https://srtr.transplant.hrsa.gov/annual_reports/2017/Kidney.aspx (last accessed 12 Dec 2021).

4. Human Rights Channel. Shortage of organs, tissues and cells for transplantation in Europe. Council of Europe 2021; available at https://www.coe.int/en/web/human-rights-channel/organ-donation (last accessed 12 Dec 2021).

5. Sinha Roy AR. World Kidney Day: With just 0.01% Indians donating organs, an ‘opt-out’ model is nation’s only hope of saving lives. First Post 2018 Mar 8; available at https://www.firstpost.com/india/world-kidney-day-with-just-0-01-indians-donating-organs-an-opt-out-model-is-nations-only-hope-of-saving-lives-4381187.html (last accessed 12 Dec 2021).

6. See note 5, Sinha Roy 2018.

7. Wyld M, Morton RL, Hayen A, Howard K, Webster AC. A systematic review and meta-analysis of utility-based quality of life in chronic kidney disease treatments. PLOS Medicine 2012;9(9):e1001307.

8. Our focus in this paper is roughly speaking on removing barriers that have to do with motivation and ethics. There are also what we may call technical barriers that could be overcome. For an overview, see Tullius SG, Rabb H. Improving the supply and quality of deceased-donor organs for transplantation. New England Journal of Medicine 2018;378:1920–29.

9. Johnson, EJ, Goldstein, DG. Do defaults save lives? Science 2003;302(5649):1338–9CrossRefGoogle ScholarPubMed.

10. Spital A. Mandated choice. A plan to increase public commitment to organ donation. JAMA 1995;273(6) 504–6CrossRefGoogle Scholar.

11. Thaysen, JD, Albertsen, A. Mandated Choice Policies: When Are They Preferable? Political Research Quarterly 2021;74(3):744–55CrossRefGoogle Scholar.

12. Kessler, JB, Roth, AE. Getting more organs for transplantation. American Economic Review 2014;104(5):425–30CrossRefGoogle ScholarPubMed.

13. Dominguez, J, Rojas, JL. Presumed consent legislation failed to improve organ donation in Chile. Transplantation 2012;94(10S):500.CrossRefGoogle Scholar

14. See note 13, Dominguez, Rojas 2012.

15. Price P. Presumed versus explicit consent and the role of relatives. Select Committee on European Union 2007 Oct 5; available at https://publications.parliament.uk/pa/ld200708/ldselect/ldeucom/123/123we19.htm (last accessed 12 Dec 2021).

16. Rosenblum, AM, Horvat, LD, Siminoff, LA, Prakash, V, Beitel, J, Garg, AX. The authority of next-of-kin in explicit and presumed consent systems for deceased organ donation: An analysis of 54 nations. Nephrology Dialysis Transplantation 2012;27:2533–46CrossRefGoogle ScholarPubMed.

17. Coppen, R, Friele, RD, Marquet, RL, Gevers, SK. Opting-out systems: No guarantee for higher donation rates. Transplantion International 2005;18:1275–9CrossRefGoogle ScholarPubMed; Sharif, A. Presumed consent will not automatically lead to increased organ donation. Kidney International 2018;94(2):249–51.CrossRefGoogle Scholar

18. Horvat, LD, Cuerden, MS, Kim, SJ, Koval, JJ, Young, A, Garg, AX. Informing the debate: Rates of kidney transplantation in nations with presumed consent. Annals of Internal Medicine 2010;153:641–9CrossRefGoogle ScholarPubMed.

19. See note 17, Sharif 2018.

20. Bilgel, F. The impact of presumed consent laws and institutions on deceased organ donation. European Journal of Health Economics 2012;13(1):2938 CrossRefGoogle ScholarPubMed; Ahmad, MU, Hanna, A, Mohamed, A-Z, Schlindwein, A, Pley, C, Bahner, I, et al. A systematic review of opt-out versus opt-in consent on deceased organ donation and transplantation (2006–2016). World Journal of Surgery 2019; 43(12):3161–71CrossRefGoogle ScholarPubMed; Shepherd, L, O’Carroll, RE, Ferguson, E. An international comparison of deceased and living organ donation/transplant rates in opt-in and opt-out systems: A panel study. BMC Medicine 2014;12:131 CrossRefGoogle ScholarPubMed; Niven J, Chalmers N. Opt out organ donation: A rapid evidence review. Health Performance and Delivery Directorate, Scottish Government 2018 Jul 20; available at https://www.gov.scot/publications/opt-out-organ-donation-rapid-evidence-review/documents/ (last accessed 12 Dec 2021); Steffel M, Williams EF, Tannenbaum D. Does changing defaults save lives? Effects of presumed consent organ donation policies. Behavioral Science & Policy 2019;5(1):68–88.

21. This could of course be the result of a selection effect; countries with citizens with more pro-donation attitudes may have implemented opt out systems. Mossialos, E, Costa-Font, J, Rudisill, C. Does organ donation legislation affect individuals’ willingness to donate their own or their relative’s organs? Evidence from European Union survey data. BMC Health Services Research 2008;8:48 CrossRefGoogle ScholarPubMed.

22. Stewart C. Rate of deceased organ donors including both donation after brain death (DBD) and donation after cardiac death (DCD) in Europe from 2019 to 2020, by country. Statista 21 Sep 2021; available at https://www.statista.com/statistics/537908/deceased-organ-donor-rate-in-europe/ (last accessed 12 Dec 2021).

23. Crespo, M, Mazuecos, A, Domínguez-Gil, B. Global perspective on kidney transplantation: Spain. Kidney 360 2021;2(11):1840–3CrossRefGoogle ScholarPubMed.

24. Mendoza J. Total number of patients on the organ transplant waiting list in Spain from 2017 to 2019, by organ. Statista Oct 2020; available at https://www.statista.com/statistics/538386/number-of-patients-active-on-organ-transplant-waiting-list-in-spain/ (last accessed 12 Dec 2021); Mendoza J. Number of patients who died while on the organ transplant waiting list in Spain from 2015 to 2019, by organ type. Statista Oct 2020; available at https://www.statista.com/statistics/540135/patient-deaths-on-the-organ-transplant-waiting-list-in-spain/ (last accessed 12 Dec 2021).

25. Ortiz, A, Sanchez-Niño, MD, Crespo-Barrio, M, De-Sequera-Ortiz, P, Fernández-Giráldez, E, García-Maset, R, et al. The Spanish Society of Nephrology (SENEFRO) commentary to the Spain GBD 2016 report: Keeping chronic kidney disease out of sight of health authorities will only magnify the problem. Nefrología 2019;39(1):2934 CrossRefGoogle Scholar.

26. Several proponents of opt out explicitly argue against the notion of presumed consent, see Saunders B. Opt-out organ donation without presumptions. Journal of Medical Ethics 2012;38(2):69–72CrossRefGoogle Scholar.

27. Harris, J. In vitro fertilisation: The ethical issues. The Philosophical Quarterly 1983;33(132):217‑38CrossRefGoogle ScholarPubMed; Harris J. The Value of Life: An Introduction to Medical Ethics. Abingdon: Routledge & Kegan Paul; 1985, chap. 6. For a defence of the same idea but discussed under the heading ‘routine recovery,’ see Spital, A, Taylor, JS. Routine recovery of cadaveric organs for transplantation: Consistent, fair, and life-saving. Clinical Journal – American Society of Nephrology 2007;2:300–3CrossRefGoogle ScholarPubMed. For proponents of automatic availability of organs from deceased donors for reasons of justice, see Rakowski, E. Equal Justice. Oxford: Clarendon; 1991 Google Scholar; Fabre, C. Whose Body Is It Anyway?: Justice and the Integrity of the Person. Oxford: Oxford University Press; 2006 CrossRefGoogle Scholar.

28. Admittedly, many people report that they want to be involved in the decision. This wish may, however, change in responsive to changes in laws and education campaigns. For a review, see Molina-Pérez, A, Delgadob, J, Frunzad, M, Morgane, M, Randhawa, G, Reiger-Van de Wijdeven, J, et al. Should the family have a role in deceased organ donation decision-making? A systematic review of public knowledge and attitudes toward organ procurement policies in Europe. Transplantation Review 2022; 36:100673CrossRefGoogle Scholar.

29. For a discussion of organ donation as Samaritan duties, see Midtgaard, S, Albertsen, A. Opt-out to the rescue: Organ donation and samaritan duties. Public Health Ethics 2021;14(2):191201 CrossRefGoogle Scholar. We do not commit to the idea that our duties of beneficence in the organ donation context is best understood as duties of easy rescue. For a discussion of rescue duties, see Sterri, A, Moen, OM. The ethics of emergencies. Philosophical Studies 2021;178:2621–34CrossRefGoogle Scholar.

30. Scanlon, TM. What We Owe to Each Other. Cambridge, MA: Harvard University Press 1998, 224 Google Scholar; Giubilini, A, Douglas, T, Maslen, H, Savulescu, J. Quarantine, isolation and the duty of easy rescue in public health. Developing World Bioethics 2018;18:182–9CrossRefGoogle ScholarPubMed.

31. Tadros, V. The Ends of Harm: The Moral Foundations of Criminal Law. New York: Oxford University Press 2011 CrossRefGoogle Scholar.

32. For contractualism, see note 30, Scanlon 1998. For insurance as the basis of a theory of distributive justice, see Dworkin, R. What is equality? Part 2: Equality of resources. Philosophy & Public Affairs 1981;10(4):283345 Google Scholar.

33. This section draws on Harris, J. Organ procurement: Dead interests, living needs. Journal of Medical Ethics 2003;29(3):130–4CrossRefGoogle ScholarPubMed.

34. For a contrary opinion, see Fabre, C. Justice and the compulsory taking of live body parts. Utilitas 2003;15(2):127150, 136.CrossRefGoogle Scholar

35. On rights theories: Wenar, L. The nature of rights. Philosophy & Public Affairs 2005;33:223–52Google Scholar.

36. Hart CLA. Essays on Bentham: Studies in Jurisprudence and Political Theory. Oxford: Clarendon Press; 1982:183.

37. For a defence of posthumous harms in the context of organ donation, see Wilkinson, TM Ethics and the Acquisition of Organs: Issues in Biomedical Ethics. Oxford, New York: Oxford University Press; 2011.CrossRefGoogle Scholar

38. Raz, J. The Morality of Freedom. Oxford: Oxford University Press; 1986:166 Google Scholar.

39. Taylor, JS The myth of posthumous harm. American Philosophical Quarterly 2005;42(4):311–22Google Scholar.

40. This is also the legal foundation of consent in the Common Law Tradition.

41. Scheffler, S. Death and Afterlife. Oxford: Oxford University Press; 2013.CrossRefGoogle Scholar

42. In, Shakespeare W. Macbeth: Proudfoot, R, Thomson, A, Kastan, DS, eds. The Arden Shakespeare, Complete Works. Walton-On-Thames: Thomas Nelson and Sons Ltd; 1998:3.4:784 Google Scholar.

43. See also Harris, J. Why kill the cabin boy? Cambridge Quarterly of Healthcare Ethics 30(1):49 CrossRefGoogle Scholar.

44. Shakespeare W. Hamlet. In: Proudfoot R, Thomson A, Kastan DS, eds. The Arden Shakespeare complete works. Walton on Thames: Thomas Nelson and Sons Ltd; 1998:4.3.

45. Harris, J. Ethical Issues in Geriatric Medicine. In: Tallis, RC, Brockelhurst, JC, Fillett, H, eds. Textbook of Geriatric Medicine and Gerontology. 5th ed. London: Churchill Livingstone; 1998 Google Scholar.

46. The issue of family veto is often discussed in the context of whether the family can overrule the will of the deceased. For an argument in favour of the family veto, see Zambrano, A. Patient autonomy and the family veto problem in organ procurement. Social Theory and Practice 2017;43(1):180200 CrossRefGoogle Scholar. For an argument against, see Albertsen, A. Against the family veto in organ procurement: Why the wishes of the dead should prevail when the living and the deceased disagree on organ donation. Bioethics 2020;34(3):272–80CrossRefGoogle ScholarPubMed.

47. Cook, PJ, Krawiec, KD. A primer on kidney transplantation: Anatomy of the shortage. Law and Contemporary Problems 2014;77:123 Google Scholar.

48. Arcos, E, Pérez-Sáez, MJ, Comas, J, Lloveras, J, Tort, J, Pascual, J. Assessing the limits in kidney transplantation: Use of extremely elderly donors and outcomes in elderly recipients. Transplantation 2020;104(1):176–83CrossRefGoogle ScholarPubMed.

49. See note 17, Sharif 2018; Sandal S, Charlebois K, Fiore JF., Wright Jr. DK, Fortin MC, Feldman LS, et al. Health professional-identified barriers to living donor kidney transplantation: A qualitative study. Canadian Journal of Kidney Health and Disease 2019;6. doi: 10.1177/2054358119828389.

50. Lentine, KL, Patel, A. Risks and outcomes of living donation. Advances in Chronic Kidney Disease 2012;19(4):220–8CrossRefGoogle ScholarPubMed; Maggiore, U, Budde, K, Heemann, U, Hildbrands, L, Oberauer, R, Oniscu, GC, et al. Long-term risks of kidney living donation: Review and position paper by the ERA-EDTA DESCARTES working group. Nephrology Dialysis Transplantation 2017;32(2):216–23CrossRefGoogle ScholarPubMed.

51. See note 50, Lentine, Patel 2012; Maggiore et al. 2017.

52. Barnieh, L, McLaughlin, K, Manns, BJ, Klarenbach, S, Yilmaz, S, Hemmelgarn, BR. For the Alberta kidney disease network, barriers to living kidney donation identified by eligible candidates with end-stage renal disease. Nephrology Dialysis Transplantation 2011;26(2):732–8CrossRefGoogle Scholar.

53. Healy, K. Last Best Gifts: Altruism and the Market for Human Blood and Organs. Chicago: Chicago University Press; 2006 CrossRefGoogle Scholar; Healy, K, Krawiec, KD. Organ entrepeneurs. In: Smith, DG, Hurt, C, eds., The Cambridge Handbook on Law and Entrepreneurship. Cambridge: Cambridge University Press; 2022 Google Scholar.

54. For an early statement of this view, see Titmuss, RM. The Gift Relationship: From Human Blood to Social Policy. New York: Vintage Books; 1972 Google Scholar.

55. Regmi S, Harris J. Una Risorsa vitale. La Donazione di organi deve rispettare le esigenze morali. In: Marino IR, Doyle HR, Boniolo G, eds. Passaggi – Storia ed Evoluzione del concetto di morte cerebrale. Roma: Il Pensiero Scientifico Editore; 2012:91–101.

56. Wesselman, H, Ford, CG, Leyva, Y, Li, X, Chang, C-CH, Dew, MA, et al. Social determinants of health and race disparities in kidney transplant. Clinical Journal of the American Society of Nephrology 2021;16(2):262–74CrossRefGoogle ScholarPubMed.

57. See note 3, Organ Procurement and Transplantation Network 2017.

58. See note 53, Healy, Krawieck 2022. The 1/3-figure is from Leeser, DB, Aull, MJ, Afaneh, C, Dadhania, D, Charlton, M, Walker, JK, et al. Living donor kidney paired donation transplantation: Experience as a founding member center of the National Kidney Registry. Clinical Transplantation 2012;26(3):E21322 CrossRefGoogle ScholarPubMed.

59. Roth, AE, Sönmez, T, Ünver, MU. Pairwise kidney exchange. Journal of Economic Theory 2005;125(2):151–88CrossRefGoogle Scholar; Biró, P, Haase-Kromwijk, B, Andersson, T, Ásgeirsson, E, Baltesová, T, Boletis, I, et al. on behalf of the ENCKEP COST action building kidney exchange programmes in Europe—An overview of exchange practice and activities. Transplantation 2019;103(7):1514–22CrossRefGoogle Scholar.

60. Nikzad, A, Akbarpour, M, Rees, MA, Roth, AE. Global kidney chains. Proceedings of the National Academy of Sciences 2021;118(36):e2106652118CrossRefGoogle ScholarPubMed.

61. Krawiec, KD, Liu, W, Melcher, ML. Contract development in a matching market: The case of kidney exchange. Law and Contemporary Problems 2017;80:1135.Google Scholar

62. Harris J. The survival lottery. Philosophy 1975;50(191): 81–7, see also note 22, Rakowski 1991; Fabre 2006.

63. This argument is developed in more detail in Sterri, AB. Why states should buy kidneys. Journal of Applied Philosophy Online First 2 Jun 2021. doi:10.1111/japp.12523 CrossRefGoogle Scholar.

64. See note 63, Sterri 2021.

65. See Erin CA, Harris J. A monopsonistic market. In: Robinson I, ed. The Social Consequences of Life & Death Under High Technology Medicine. Manchester: Manchester University Press; 1994:134–57; Erin, CA, Harris, J. An ethical market in human Organs. The Journal of Medical Ethics 2003;29(3):137–8CrossRefGoogle ScholarPubMed. Some have proposed a future market in organs, where the living can sell their organs for harvesting when they are dead. Our proposal to make organs automatically available makes this proposal unnecessary. For a comparison of regulated markets and future markets, see Albertsen, A. If the Price is right: The ethics and efficiency of market solutions to the organ shortage. Journal of Bioethical Inquiry 2020;17(3):357–67CrossRefGoogle Scholar.

66. Semrau, L. Kidneys save lives: Markets would probably help. Public Affairs Quarterly 2014;28(1):7193 Google Scholar. The price is significantly higher than the market clearing price of $15,000 estimated by Gary S. Becker and Julio J. Becker, see Becker, GS, Elías, JJ. Introducing incentives in the market for live and cadaveric organ donations. Journal of Economic Perspectives 2007;21(3):324.CrossRefGoogle ScholarPubMed

67. The Kidney Project. Statistics. University of California San Francisco. Available at: https://pharm.ucsf.edu/kidney/need/statistics (last accessed 12 Dec 2021).

68. Held, PJ, McCormick, F, Ojo, AO, Roberts, JP. A cost-benefit analysis of government compensation of kidney donors. American Journal of Transplantation 2016;16(3):877–85CrossRefGoogle ScholarPubMed.

69. NHS blood and transplant. Cost-effectiveness of transplantation. NHS Oct 2009, available at https://nhsbtmediaservices.blob.core.windows.net/organ-donation-assets/pdfs/Organ_Donation_Registry_Fact_Sheet_7_21337.pdf (last accessed 14 Dec 2021).

70. Fatemi, F. The regulated market for kidneys in Iran. In: Coles, P, Das, S, Lahaie, S, Szymanski, B, eds. Auctions, Market Mechanisms, and Their Applications. AMMA 2011. Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering . Berlin, Heidelberg: Springer; 2012;80 Google Scholar.

71. Radcliffe-Richards, J. The Ethics of Transplants: Why Careless Thought Costs Lives. Oxford: Oxford University Press; 2012 Google Scholar.

72. See note 63, Sterri 2 Jun 2021.

73. Sandel, MJ. What money Can’t buy: The moral limits of markets. Tanner Lectures on Human Values 2000;21:87122 Google Scholar.

74. Sterri, AB. Prize, not price: Reframing rewards for kidney donors. Journal of Medical Ethics 2021;47:e57.CrossRefGoogle Scholar

75. Commentary, Radcliffe-Richards J.. An ethical market in human organs. Journal of Medical Ethics 2003;29:139–40.Google Scholar