Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-26T15:08:12.043Z Has data issue: false hasContentIssue false

Effect of managed transition on mental health outcomes for young people at the child–adult mental health service boundary: a randomised clinical trial

Published online by Cambridge University Press:  29 October 2021

S. P. Singh*
Affiliation:
Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Coventry, UK Coventry and Warwickshire Partnership NHS Trust, Coventry, UK
H. Tuomainen
Affiliation:
Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Coventry, UK
G. Bouliotis
Affiliation:
Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK
A. Canaway
Affiliation:
Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK
G. De Girolamo
Affiliation:
IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
G. C. Dieleman
Affiliation:
Department of Child and Adolescent Psychiatry and Psychology, Erasmus Medical Center, Rotterdam, the Netherlands
T. Franić
Affiliation:
Department of Psychiatry, Clinical Hospital Center Split, Split, Croatia
J. Madan
Affiliation:
Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK
A. Maras
Affiliation:
Department of Child and Adolescent Psychiatry and Psychology, Erasmus Medical Center, Rotterdam, the Netherlands Yulius Academy, Rotterdam, the Netherlands
F. McNicholas
Affiliation:
Department of Child and Adolescent Psychiatry, University College Dublin School of Medicine and Medical Science, Dublin, Republic of Ireland Geary Institute, University College Dublin, Dublin, Republic of Ireland Department of Child Psychiatry, Our Lady's Hospital for Sick Children, Dublin, Republic of Ireland Lucena Clinic SJOG, Dublin, Republic of Ireland
M. Paul
Affiliation:
Coventry and Warwickshire Partnership NHS Trust, Coventry, UK
D. Purper-Ouakil
Affiliation:
Centre Hospitalier Universitaire de Montpellier, Saint Eloi Hospital, Unit of Child and Adolescent Psychiatry (MPEA1), Montpellier, France
P. Santosh
Affiliation:
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK Centre for Interventional Paediatric Psychopharmacology and Rare Diseases (CIPPRD), National and Specialist Child and Adolescent Mental Health Services, Maudsley Hospital, London, UK HealthTracker Ltd, Gillingham, UK
U. M. E. Schulze
Affiliation:
Department of Child and Adolescent Psychiatry/Psychotherapy, University of Ulm, Ulm, Germany
C. Street
Affiliation:
Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Coventry, UK
S. Tremmery
Affiliation:
Department of Neurosciences, Child & Adolescent Psychiatry, University of Leuven, Leuven, Belgium
F. C. Verhulst
Affiliation:
Department of Child and Adolescent Psychiatry and Psychology, Erasmus Medical Center, Rotterdam, the Netherlands Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
P. Wells
Affiliation:
Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK
D. Wolke
Affiliation:
Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Coventry, UK Department of Psychology, University of Warwick, Coventry, UK
J. Warwick
Affiliation:
Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK
*
Author for correspondence: S. P. Singh, E-mail: S.P.Singh@warwick.ac.uk
Rights & Permissions [Opens in a new window]

Abstract

Background

Poor transition planning contributes to discontinuity of care at the child–adult mental health service boundary (SB), adversely affecting mental health outcomes in young people (YP). The aim of the study was to determine whether managed transition (MT) improves mental health outcomes of YP reaching the child/adolescent mental health service (CAMHS) boundary compared with usual care (UC).

Methods

A two-arm cluster-randomised trial (ISRCTN83240263 and NCT03013595) with clusters allocated 1:2 between MT and UC. Recruitment took place in 40 CAMHS (eight European countries) between October 2015 and December 2016. Eligible participants were CAMHS service users who were receiving treatment or had a diagnosed mental disorder, had an IQ ⩾ 70 and were within 1 year of reaching the SB. MT was a multi-component intervention that included CAMHS training, systematic identification of YP approaching SB, a structured assessment (Transition Readiness and Appropriateness Measure) and sharing of information between CAMHS and adult mental health services. The primary outcome was HoNOSCA (Health of the Nation Outcome Scale for Children and Adolescents) score 15-months post-entry to the trial.

Results

The mean difference in HoNOSCA scores between the MT and UC arms at 15 months was −1.11 points (95% confidence interval −2.07 to −0.14, p = 0.03). The cost of delivering the intervention was relatively modest (€17–€65 per service user).

Conclusions

MT led to improved mental health of YP after the SB but the magnitude of the effect was small. The intervention can be implemented at low cost and form part of planned and purposeful transitional care.

Type
Original Article
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

Introduction

Transition from paediatric to adult care is problematic in many health specialities, but most severe, complex and challenging in mental health care (Singh, Anderson, Liabo, & Ganeshamoorthy, Reference Singh, Anderson, Liabo and Ganeshamoorthy2016). It should be a planned and purposeful process which addresses the needs of young people (YP) as they move to adult services and towards independence (Paul et al., Reference Paul, Ford, Kramer, Islam, Harley and Singh2013). Previous studies suggest that transition is ‘poorly planned, poorly executed, and poorly experienced’ (Singh et al., Reference Singh, Paul, Ford, Kramer, Weaver, McLaren and White2010). Many YP experience discontinuity or disengagement from care on reaching the child–adult mental health service boundary (SB) (Appleton, Connell, Fairclough, Tuomainen, & Singh, Reference Appleton, Connell, Fairclough, Tuomainen and Singh2019; Leavey et al., Reference Leavey, McGrellis, Forbes, Thampi, Davidson, Rosato and Singh2019; Singh et al., Reference Singh, Paul, Ford, Kramer, Weaver, McLaren and White2010), with potentially adverse impact on their health and wellbeing (Davis, Koroloff, Sabella, & Sarkis, Reference Davis, Koroloff, Sabella and Sarkis2018). Barriers to optimal transition between child/adolescent mental health service (CAMHS) and adult mental health service (AMHS), although well-documented, are complex to overcome (Hovish, Weaver, Islam, Paul, & Singh, Reference Hovish, Weaver, Islam, Paul and Singh2012). Core elements needed to improve transition are implementing policy, tracking and monitoring transition readiness, transition planning, transfer of care, and completion (Cleverley, Rowland, Bennett, Jeffs, & Gore, Reference Cleverley, Rowland, Bennett, Jeffs and Gore2020; Singh et al., Reference Singh, Anderson, Liabo and Ganeshamoorthy2016). There is as yet no standardised, shared or robustly tested model of transitional care in the published literature (Singh et al., Reference Singh, Anderson, Liabo and Ganeshamoorthy2016; Tuomainen, Appleton, & Singh, Reference Tuomainen, Appleton, Singh, Taylor, Verhulst, Wong, Yoshida and Nikapota2020). MILESTONE was an eight-country 5-year EU-funded project to improve the experiences of YP at the child/adolescent to AMHS interface (Tuomainen et al., Reference Tuomainen, Schulze, Warwick, Paul, Dieleman, Franic and Singh2018). The project comprised of nine distinct but inter-related work packages, which have been described elsewhere (Singh et al., Reference Singh, Tuomainen, Girolamo, Maras, Santosh, McNicholas and Walker2017; Tuomainen et al., Reference Tuomainen, Schulze, Warwick, Paul, Dieleman, Franic and Singh2018). We created a Transition Readiness and Appropriateness Measure (TRAM) (Santosh et al., Reference Santosh, Singh, Adams, Mastroianni, Heaney, Lievesley and Singh2020b), which systematically identifies the needs, preferences and readiness of YP for ongoing adult care, including those who can be appropriately discharged. Based on the TRAM, we developed a model of transitional care, managed transition (MT) (online Supplementary Fig. S1) (Singh et al., Reference Singh, Tuomainen, Girolamo, Maras, Santosh, McNicholas and Walker2017). We conducted a cluster-randomised trial to assess the effect of MT on mental health outcomes of YP approaching the SB of their CAMHS compared with usual care (UC) and a within-trial economic evaluation to estimate the cost-effectiveness of MT.

Methods

Design

We conducted an eight-country, two-arm, parallel design, superiority, cluster-randomised controlled trial (cRCT) to assess whether MT improves mental health outcomes in YP approaching the CAMHS SB, compared to UC. The cRCT with economic evaluation was embedded within the MILESTONE longitudinal study (ISRCTN83240263 and NCT03013595), described elsewhere and funded by the European Union (Singh et al., Reference Singh, Tuomainen, Girolamo, Maras, Santosh, McNicholas and Walker2017). Participating countries were Belgium, Croatia, France, Germany, Ireland, Italy, Netherlands and the UK. The authors assert that all procedures contributing to this study comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008. All procedures involving human subjects were approved in the UK by the National Research Ethics Service Committee West Midlands – South Birmingham (15/WM/0052) and equivalent ethics boards in the participating countries. The study protocol has been published (Singh et al., Reference Singh, Tuomainen, Girolamo, Maras, Santosh, McNicholas and Walker2017).

Trial setting, eligibility and participants

Participating CAMHS were organisations delivering medical and psychosocial interventions for children/adolescents with mental health and/or neuropsychiatric/developmental disorders. Services could be publicly or privately funded but had to have a formal upper age limit (the SB) for providing care. Forensic services and highly specialised services were excluded. The child/adolescent to adult mental health SB was typically 18 years but varied according to local practice (online Supplementary Table S2). Eligible participants were YP with a mental disorder defined by DSM-IV-TR, DSM-5 or ICD 10/11, who were receiving CAMHS care, with an IQ ⩾ 70 and within 1 year of reaching CAMHS SB. Recruitment occurred between 1st October 2015 and 31st December 2016. Because transition decisions were sometimes made after the YP reached the SB, we amended the eligibility criteria (in April 2016) to include YP who were up to 3-months older than the SB.

Participants were identified by clinicians, and other care staff, and recruited by local study personnel. The YP's parent (legal guardian, a partner, an older adult sibling or another individual) was also invited to participate, provided the young person agreed. Written informed consent was obtained from all participants. For YP below the age of consent (UK <16, Europe <18), a parent/legal guardian was required to provide consent, with the YP signing an assent form. YP involved in the study were offered incentives as ‘token of thanks’ for participating. Incentives were shopping vouchers (in all countries but Italy and Croatia) and/or being entered into a prize draw (Singh et al., Reference Singh, Tuomainen, Girolamo, Maras, Santosh, McNicholas and Walker2017). Further details of methodology and design have been reported elsewhere (Singh et al., Reference Singh, Tuomainen, Girolamo, Maras, Santosh, McNicholas and Walker2017).

Randomisation and masking

Clusters were individual CAMHS recruited to the MILESTONE study (cRCT, economic evaluation and longitudinal cohort study) (Singh et al., Reference Singh, Tuomainen, Girolamo, Maras, Santosh, McNicholas and Walker2017). Randomisation (2:1 between UC and MT) was undertaken in two stages and stratified by country to ensure that the number of clusters per country was divisible by 3 and that all countries had both control and intervention clusters. It was not feasible to blind clinicians or the research team, but YP and parents/carers were informed of trial arm, only if requested, after consenting to participate.

Trial interventions

MT (online Supplementary Fig. S1) was a multi-component intervention that included CAMHS training, systematic identification of YP approaching SB, a structured assessment (TRAM) and feedback of the TRAM findings to the CAMHS clinician (via the TRAM summary report). Prior to opening to recruitment, CAMHS clinicians at the intervention sites were invited to a single standardised training session on good/effective transition and interpretation of the TRAM summary report. Once the TRAM summary report relating to a participant (online Supplementary Fig. S2) was ready, it was sent to the CAMHS clinician along with a letter advising that it should be discussed with the YP and parent/carer and attached to any referral letter to AMHS (online Supplementary Fig. S3). To reinforce the learning undertaken during training, a leaflet reminding the CAMHS clinician why care in transition is important, and what YP say helps them with transition, was also included (online Supplementary Fig. S4). Clinicians in the UC group did not receive the TRAM summary report or any training regarding transition.

Data collection

Outcomes were assessed at baseline, 9 months and 15 months using structured interviews (by research assistants not blinded to group membership) and self-reported measures (online Supplementary Table S3). Data were collected via a web-based, secure, data capture system (HealthTracker™). Interviews to complete the Health of the Nation Outcome Scale for Child and Adolescents (HoNOSCA) were held at the CAMHS, the participant's home, or an alternative location (according to the participant's preference). Participants were asked to complete other measures within 2 weeks of the HoNOSCA interview but were allowed a 3-month window.

Outcomes

Primary outcome

The primary outcome was HoNOSCA score 15-months post-entry to the trial (Garralda, Yates, & Higginson, Reference Garralda, Yates and Higginson2000; Gowers et al., Reference Gowers, Harrington, Whitton, Lelliott, Beevor, Wing and Jezzard1999). This validated and internationally widely implemented global outcome measure for child/adolescent mental health care includes domains of symptoms, behaviour, impairments and social functioning (Harris et al., Reference Harris, Sparti, Scheurer, Coombs, Pirkis, Ruud and Burgess2018). Items 1–13 are scored on a scale of 0–4 (0 indicates no problem, 4 severe problem; a detailed glossary describes scales for each item) (Ballesteros-Urpí et al., Reference Ballesteros-Urpí, Pardo-Hernández, Ferrero-Gregori, Torralbas-Ortega, Puntí-Vidal, Tàpies Olivet and Morer2018; Harris et al., Reference Harris, Sparti, Scheurer, Coombs, Pirkis, Ruud and Burgess2018). The total score, indicating the severity of the mental health problem/s, is the sum of the 13 items. HoNOSCA was completed by a trained Research Assistant following semi-structured interviews with the young person, and (where possible) with parent/carer and relevant clinician (or review of medical records if the relevant clinician was not available).

Secondary outcomes

Secondary outcomes were self-reported HoNOSCA score (HoNOSCA-SR) (Gowers, Levine, Bailey-Rogers, Shore, & Burhouse, Reference Gowers, Levine, Bailey-Rogers, Shore and Burhouse2002), transition outcomes (TROM) (Santosh et al., Reference Santosh, Adams, Fiori, Davidović, de Girolamo, Dieleman and Singh2020a), quality of life (WHOQOL-BREF) (Skevington, Lotfy, & O'Connell, Reference Skevington, Lotfy and O'Connell2004), functioning and impairment (SLOF) (Mucci et al., Reference Mucci, Rucci, Rocca, Bucci, Gibertoni, Merlotti and Maj2014), self-reported emotional/behaviour problems (YSR/ASR) (Achenbach & Rescorla, Reference Achenbach and Rescorla2001), parent/carer reported emotional/behavioural problems (CBCL/ABCL) (Achenbach & Rescorla, Reference Achenbach and Rescorla2003), independent behaviour (IBDCS) (van Staa, Reference van Staa2011), illness severity (CGIS) (Guy, Reference Guy1976), transfer experience (OYOF-TES) (van Staa & Sattoe, Reference van Staa and Sattoe2014), health-related quality of life (EQ-5D-5L) (Herdman et al., Reference Herdman, Gudex, Lloyd, Janssen, Kind, Parkin and Badia2011) and resource utilisation (CSRI) (Chisholm et al., Reference Chisholm, Knapp, Knudsen, Amaddeo, Gaite and Van Wijngaarden2000). Further details on outcome measures are given in online Supplementary Table S4. Information on YP's referral and transition status was collected from their CAMHS clinician. Information on severe adverse events (SAEs) was collected, specifically self-harm, suicidal thoughts, suicide through physical harm or with drugs, or death.

Statistical analysis

Assuming an average cluster size of 15 participants, an allocation ratio of 2:1 (control:intervention), a coefficient of variation of cluster size of 0.4 (cluster size ranging from 5 to 30), and an intra-cluster correlation coefficient of 0.01, we estimated that with 600 participants [195 intervention arm (13 clusters), 405 control arm (27 clusters)] the trial would have 89% power to detect a difference of 0.30 standard deviations (s.d.s) in the primary outcome measure (HoNOSCA). Allowing for 30% attrition, we aimed to recruit 21 participants per cluster. The target sample size was, therefore, 840 participants in total (273 intervention; 567 control).

We tested the null hypothesis of no difference in mean HoNOSCA score between the MT and UC groups at month 15 post-randomisation, using a generalised linear mixed effect model (GLMM) with random and fixed effects (to allow for the hierarchical structure of the data and adjust for trial arm, time point and baseline characteristics, HoNOSCA score, gender and diagnosis). Secondary outcomes HoNOSCA-SR and quality of life (WHOQOL-BREF) were analysed using a hierarchical linear mixed model with random effects for the four levels (country, site, participant and follow-up time) and adjustment for the same fixed effects. For other secondary outcomes, descriptive analyses were conducted. The significance level was set at 5%, with no adjustment for multiple testing. All analyses were on an intention-to-treat basis and followed a pre-specified statistical analysis plan (available at https://www.milestone-transitionstudy.eu/).

To examine the cost of implementing the intervention, clinicians were invited to complete a questionnaire on the time burden of completing TRAM. Time spent by the Warwick team preparing and checking TRAM reports was also recorded. We also captured the resources required to set up the intervention and conduct initial training of clinicians. Resource use data were combined with unit cost data (see online Supplementary appendix, ‘Intervention costing’) to estimate intervention costs.

All analyses were conducted using Stata 16 (StataCorp, 2019).

Results

Participants

Participant flow through the trial, including numbers screened, numbers recruited, withdrawals and loss to follow-up are shown in Fig. 1. In all, 844 YP were recruited (1st Oct 2015–31st Dec 2016) from 40 CAMHS, including 19 YP who withdrew before baseline assessment. A further 32 participants (at a single site in Croatia) were excluded owing to uncertainty concerning validity of participant consent, so 793 were available for the baseline assessments [Table 1 (abridged), online Supplementary Table S1 (full version)]; 273 in the MT group and 552 in the UC group. Attrition rates at 15 months were similar in the trial arms (4% UC group; 5% MT group). Reasons for withdrawal, where given, were similar in both trial arms – mainly being too busy and not wanting to talk about mental health problems. Online Supplementary Fig. S5 is a CONSORT diagram illustrating the number and sizes of clusters (CAMHS) recruited and randomised to the MILESTONE study (cRCT, economic evaluation and longitudinal cohort study). Further information about participating CAMHS (whether community and/or hospital based, existence of transition policy and means of funding) is given in online Supplementary Table S2. Baseline demographic and clinical characteristics of participants were generally well-balanced between the trial arms except that YP in the MT group were slightly more unwell (as shown by the HoNOSCA, TRAM and CGI scores, Table 1). Baseline characteristics of other participants (parent/carers, CAMHS and AMHS clinicians) are given by trial arm in online Supplementary Tables S5–S7.

Fig. 1. Participant flow through the trial.

Table 1. Baseline characteristics of participants (abridged versiona)

a For full baseline characteristics see online Supplementary Table S1.

b We randomised three clusters from Croatia (two to the UC arm and one to MT) but had to withdraw one of the clusters (MT arm) from the study due to uncertainty regarding the validity of participant consent. The data collected from this site are therefore excluded from the analysis.

c Includes 42 with specific learning disorders (36 UC, 6 MT), 74 with autism (56 UC, 18 MT) and 97 with ADHD (69 UC, 28 MT).

d Includes relational problems and other circumstances of personal history.

Transition decisions

To inform transition decisions, 219 TRAM summary reports were produced for clinicians in the MT arm, relating to 91% of the YP in that group. At 15 months follow-up, 26.5% of participants were still under the care of their original CAMHS (27.4% UC v. 24.5% MT) (online Supplementary Table S8). Clinicians in the MT group recommended continuing in CAMHS slightly more frequently than in the UC group (25.0% UC v. 28.6% MT) and also transition to AMHS (21.0% UC v. 27.0% MT). Slightly more YP had been accepted by, and were under the care of, their new service at 15 months follow-up in the MT group compared to UC (22.1% UC v. 28.2% MT). The number of YP rejected by or not yet seen by the new service was small (0.54% UC v. 1.2% MT). In the MT group, 35.3% of clinicians reported sharing, or intending to share, the TRAM findings with the young person, despite the fact this was not a requirement of the intervention. Similarly, a very small number of CAMHS clinicians in the UC group (3.44%) also reported having shared, or intending to share, the TRAM findings with the young person but as they did not receive the TRAM summary report, these responses must (if not reporting errors) refer to the clinician version of the TRAM and may therefore indicate contamination.

Primary outcome

Unadjusted mean HoNOSCA scores differed significantly between the MT and UC groups at baseline and at 15 months, and declined over time in both groups (online Supplementary Fig. S6). This indicated general improvement in mental health and wellbeing over time in both groups but the reduction appeared more rapid in the MT group (online Supplementary Fig. S7). The difference in mean HoNOSCA scores between the trial arms (MT-UC) at 15 months, estimated by the GLMM, was −1.11 [95% confidence interval (CI) −2.07 to −0.14, p = 0.03] (Table 2). The difference between the UC and MT trial arms in the rate of change in the HoNOSCA score over the study period (baseline to 15 months) was −1.70 (95% CI −2.97 to −0.43, p = 0.009). The intraclass-correlation coefficient between HoNOSCA scores in the same country was 0.004 (95% CI 0.000–0.782), between HoNOSCA scores in the same cluster and country was 0.037 (95% CI 0.018–0.076) and between HoNOSCA scores in the same participant, cluster and country was 0.110 (95% CI 0.068–0.173). Country, cluster and individual random-effects accounted for only 12.3% of the total residual variation. The results of sensitivity, subgroup and exploratory analyses of the primary outcome are presented in the online Supplementary appendix (Figs S8 and S9).

Table 2. Statistical analysis of primary and secondary outcomes 15 months after entry to the study

a Mean difference in the HoNOSCA score between the trial arms (MT–UC) at 15 months, from a multilevel model with four levels (country, site, participant and follow-up time) and adjustment for gender, baseline HoNOSCA score and diagnosis (categorised as anxiety, depression, neurodevelopmental disorder or other).

b Mean difference in HoNOSCA-SR score between the trial arms (MT–UC) at 15 months, from a multilevel model with four levels (country, site, participant and follow-up time) and adjustment for gender, baseline HoNOSCA-SR score and diagnosis (categorised as anxiety, depression, neurodevelopmental disorder or other).

c Mean difference in WHOQOL-BREF score between the trial arms (MT–UC) at 15 months, from a multilevel model with four levels (country, site, participant and follow-up time) and adjustment for gender, baseline WHOQOL-BREF score and diagnosis (categorised as anxiety, depression, neurodevelopmental disorder or other).

Secondary outcomes

After adjusting for HoNOSCA-SR at entry, gender, clinical diagnosis and clustering, the difference in mean HoNOSCA-SR scores between the trial arms (MT-UC) at 15 months was −1.71 (95% CI −2.88 to −0.55, p = 0.004) (Table 2). There was no significant difference in the quality of life ratings (WHO-BREF) between the trial groups at 15 months (after adjusting for clustering, baseline WHO-BREF score, gender and clinical diagnosis). Other secondary outcomes are summarised in Table 3. As these data have not been adjusted to account for clustering and imbalances in clinical and demographic factors at baseline, they should be interpreted cautiously. There were no marked differences between the UC and MT groups for the majority of measures [IBDCS, YSR/ASR, CBCL/ABCL, number of life events, CGIS, EQ-5D, SLOF, OYOF-TES (YP), OYOF-END (YP), OYOF-END (PC) and TROM] but parents/carers of YP who were to transition to AMHS did report satisfaction with end of care, and satisfaction with preparation for end of care, slightly more often in the MT group than with UC group (38.6% v. 35.5% and 40.2% v. 37.8%, respectively). There was no difference in overall satisfaction between these groups, however, with parent/carers in both groups reporting fairly high levels of satisfaction overall (average scores were 7/10 on a 0–10 scale, where 0 indicates completely unsatisfied and 10 fully satisfied).

Table 3. Summary of other secondary outcomes 15 months after entry to the studya

a As there was no adjustment for the hierarchical nature of the data or imbalances in clinical and demographic factors at baseline, the descriptive data should be interpreted cautiously.

b Calculated as the proportion of the UC group (N = 552).

c Calculated as the proportion of the MT group (N = 241).

d Completed only if the young person is still under the care of CAMHS/AMHS at 15 months.

e CGIS is only measured in those who are service users – hence missing reflects Not Applicable as well as true missing.

f Completed if the transition decision was to refer the young person to AMHS.

g Completed if the transition decision was to discharge the young person from mental health services.

h The TROM was completed at the first follow-up after the transition decision had been made, at either of the 9 and 15 months follow-up.

Self-harm (suicide, suicide attempt and suicidal thoughts) was the most common serious adverse event (online Supplementary Table S9). None were assessed to be related to participation or the intervention, and there was no difference in pattern, severity or frequency of SAEs between trial arms.

The intervention was relatively inexpensive to implement, with direct intervention delivery costs ranging between €17 and €65 per child and clinician training costs ranging between €22 and €176, depending on how training and delivery was conducted in each country.

Discussion

This is the first-ever RCT of a scalable intervention for improving mental health outcomes for YP at the child–adult SB. We met our original recruitment target and retention of participants was better than expected: 15-month primary outcome was assessed in 76% (602/793) of the cohort across eight countries. Overall, the trial covered 38 child/adolescent services in eight European countries making the study findings generalisable to a range of settings.

We developed and tested a new intervention, MT, in eight European countries (Singh et al., Reference Singh, Tuomainen, Girolamo, Maras, Santosh, McNicholas and Walker2017). Our model, based on available evidence (Paul, Street, Wheeler, & Singh, Reference Paul, Street, Wheeler and Singh2015), includes structured assessments of transition need, readiness and appropriateness, and facilitated shared decision-making between YP, parent/carer, CAMHS clinician and, where appropriate, with AMHS clinicians. The intervention uses relatively few resources, is easily incorporated into routine clinical practice and is generalisable to scale. We found that compared to UC, MT led to a small improvement in overall mental health and wellbeing of YP 15 months after entry to the trial. Furthermore, improvement was more rapid than with UC.

Our MT model ensures that the process of transition is planned and purposeful, and addresses the needs of YP as they reach the upper age SB and move towards independence (Paul et al., Reference Paul, Ford, Kramer, Islam, Harley and Singh2013). In our model, young person and their carer are closely involved in preparation for leaving one service and joining another, with adequate information sharing and a service alignment to maintain therapeutic continuity (Cleverley et al., Reference Cleverley, Rowland, Bennett, Jeffs and Gore2020; Singh et al., Reference Singh, Anderson, Liabo and Ganeshamoorthy2016). Our model of MT is relatively easy to implement: data collation can be fully automated within a web-based platform and incorporated into routine care. The paper-version of the TRAM is available in seven languages and is free of charge to charities and publicly funded organisations (requests to corresponding author). Although the need for such a model has often ben articulated, our study shows that transition process can be improved with modest investment of time and resources. TRAM and the MT model may also lend themselves, with appropriate modifications, to other clinical settings and disciplines where transition between services is unsatisfactory (Hart, Patel-Nguyen, Merkley, & Jonas, Reference Hart, Patel-Nguyen, Merkley and Jonas2019).

Previous attempts at improving service transition in mental health are few, and no RCT has ever been conducted (Appleton et al., Reference Appleton, Connell, Fairclough, Tuomainen and Singh2019; Paul et al., Reference Paul, Street, Wheeler and Singh2015). A recent study used a ‘shared management model’ with individualised transitional care plans and a transition coordinator (Cappelli et al., Reference Cappelli, Davidson, Racek, Leon, Vloet, Tataryn and Thatte2016) and another a streamlined transition process for YP in an attention deficit hyperactivity disorder transition clinic (Moosa & Sandhu, Reference Moosa and Sandhu2015). Both reduced the number of YP waiting for a referral and improved access to AMHS, but did not measure mental health outcomes after transition. Another recent innovation is extending the CAMHS boundary beyond 18, such as in Australia (McGorry, Bates, & Birchwood, Reference McGorry, Bates and Birchwood2013) and in the UK (Norfolk and Birmingham). In Norfolk, UK, a redesigned 14–25 year service increased referrals to the service, yet the proportion of accepted referrals dropped (Maxwell et al., Reference Maxwell, Ugochukwu, Clarke, Gee, Clarke, Westgate and Goodyer2019). The 14–25 model also risks creating another SB at 14. An evaluation of the 0–25 service in Birmingham, UK, found that a shortage of medical staff, poor service infrastructure, inadequate or incompatible data management systems, among other things, hampered care provision despite widespread support for the model (Birchwood et al., Reference Birchwood, Street, Singh, Lamb, Anderson, WarnerGale and Upthegrove2018).

Our MT model provides a solution that can be applied within existing service structures. For more robust transitional health care for YP, the MT model could be implemented as part of a comprehensive package of service alignment. The MT model is far less resource intensive than large-scale service reorganisation such as the 0–25 model, multi-component transition-specific programmes, or youth-friendly service models (Hetrick et al., Reference Hetrick, Bailey, Smith, Malla, Mathias, Singh and McGorry2017; McGorry et al., Reference McGorry, Bates and Birchwood2013). The overall service alignment should take other aspects of transition into account (Cleverley et al., Reference Cleverley, Rowland, Bennett, Jeffs and Gore2020; Singh et al., Reference Singh, Anderson, Liabo and Ganeshamoorthy2016), including transition to non-mental health services (Appleton et al., Reference Appleton, Connell, Fairclough, Tuomainen and Singh2019).

The modest clinical gains of our trial need to be interpreted in the context of the need for a single quantitative primary outcome measure for a process-related study. Finding a suitable measure for the primary outcome was difficult, owing to the nature of the intervention and clinical diversity of the participants. We decided on HoNOSCA because it was developed for child/adolescent mental health care settings and is used widely in Europe (Garralda et al., Reference Garralda, Yates and Higginson2000; Harris et al., Reference Harris, Sparti, Scheurer, Coombs, Pirkis, Ruud and Burgess2018). Baseline HoNOSCA scores were low in the trial (mean = 12.14, s.d. = 6.98), in keeping with comparative groups in the UK (mean = 13.71) (Gowers et al., Reference Gowers, Harrington, Whitton, Lelliott, Beevor, Wing and Jezzard1999) and Italy (mean = 13.6) (D'Avanzo et al., Reference D'Avanzo, Lovaglio, Parabiaghi, Conti, Frigerio and Molteni2018). The reduction in the mean HoNOSCA score observed with MT (1.11 points) therefore corresponds to an approximate 9% relative reduction in the HoNOSCA score, equivalent to each participant having a 1 point reduction in symptom severity on 1–2 of the 13 questions (from moderately severe to mild, say, or from severe to moderately severe).

We were surprised at the relatively large proportion of YP still in CAMHS or without a transition decision at 15 months, but similar findings have been confirmed in a recent systematic review (Appleton et al., Reference Appleton, Connell, Fairclough, Tuomainen and Singh2019). It perhaps reflects the diverse funding structures across the EU, with CAMHS in some countries able and willing to continue providing care beyond the SB (Signorini et al., Reference Signorini, Singh, Boričević, Dieleman, Dodig-Curkovic and Franic2017, Reference Signorini, Singh, Marsanic, Dieleman, Dodig-Ćurković and Franic2018). Discharge of YP who do not require transition to AMHS may be challenging for CAMHS clinicians because many primary care services feel under-resourced and poorly equipped to meet the complex needs of these YP (Tatlow-Golden, Prihodova, Gavin, Cullen, & McNicholas, Reference Tatlow-Golden, Prihodova, Gavin, Cullen and McNicholas2016).

There are, as in any trial, limitations of this study. The most unwell may be underrepresented; so we may have missed some for whom transition is essential but particularly challenging. We could not blind the CAMHS clinicians or assessors; the former was unavoidable given the nature of the intervention, but the latter was imposed due to resourcing issues. Blinding of assessors would have required two research assistants per recruitment site: one to deal with training, recruitment and the administrative aspects of the trial and another to undertake HoNOSCA interviews and assessments. This may also have made it more difficult for our research assistants to bond with participants, as each participant would now have two contacts within the research team to develop a relationship with rather than one. For clinicians in the UC arm, knowledge of the trial may have enhanced their focus on transition options. Furthermore, although, clinicians in the UC arm did not receive the TRAM summary report they did complete the clinician version of the TRAM, which may also have influenced their decision making.

Supplementary material

The supplementary material for this article can be found at https://doi.org/10.1017/S0033291721003901

Data

Requests for original (fully anonymised) participant data may be made to the corresponding author.

Acknowledgements

MILESTONE Consortium (full list of members in the Supplementary material): MILESTONE research assistants: UK: Priya Tah, James Griffin, Rebecca Appleton (University of Warwick), Natalie Heaney, Kate Lievesley, Mathilde Mastroianni, Jatinder Singh (Kings College London), Laura Adams (University of Plymouth); Italy: Giulia Signorini, Alessandro Ferrari, Elisa Gheza, Cecilia Ferrari, Laura Rivolta, Flavia Levi, Maria Cataldo, Lidia Manenti, Giorgia Morini, Adriana Pastore, Pamela Stagni, Cecilia Toselli, Pamela Varvara (Unit of Epidemiological and Evaluation Psychiatry – UOPEV, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia); France: Frédérick Russet, Virginie Maurice, Véronique Humbertclaude (Centre Hospitalier Universitaire de Montpellier); Netherlands: Larissa S. van Bodegom, Mathilde M. Overbeek (Yulius Academy); Suzanne E. Gerritsen (Erasmus Medical Centre); Germany: Melanie Saam, Ulrike Breuninger (University of Ulm); Belgium: Gaëlle Hendrickx, Veronique de Roeck (Katholieke Universiteit Leuven); Ireland: Ingrid Holme, Aleksandra Gronostaj, Rachael McKenna, Lesley O'Hara (University College Dublin); Croatia: Nikolina Davidović, Helena Tomljenovic (University Hospital Split). We extend our deepest gratitude to all the young people and their parents/carers who participated in the study, and to the child/adolescent and adult mental health services and local research teams who facilitated recruitment and assessments. The study would not have been possible without the unstinting efforts of our research assistants in the eight countries, listed above. We are highly grateful to their contribution. Andrea Wohner, our project manager at concentris Research Management, Fürstenfeldbruck, Germany, deserves special praise for excellent project management and delivery, as does Rose-Marie Lomax (University of Warwick) for stellar research administration. We also sincerely thank all temporary research staff, MSc students and medical students in the various countries who have contributed along the way. We also thank the members of our Scientific, Clinical and Ethical Advisory Board members – Prof Maryann Davis, Prof Pat McGorry, Prof Adriana Mihai and Prof Norman Sartorius – for their support, advice and encouragement throughout the research programme. The UK young advisors, Amanda Tuffrey, Anna Wilson, Charlotte Gatherer and Leanne Walker reviewed the proposed study scales (including the likely time required for completion, to assess for possible burden on study participants), participated in the design of the intervention leaflet and reviewed all study information material before submission to ethics. We are very grateful for their contribution.

Author contributions

SPS was the chief investigator who conceived the original study design and obtained funding, together with AM, GdG, PS, JM, FM, DPO, ST, US, TF, CS, MP, DW, FV and GD. HT was the study coordinator who prepared the first draft and subsequent versions of this manuscript with JW and is joint first author with SPS. JW was the senior trial statistician who oversaw the team undertaking the statistical analyses. GB and PW undertook the statistical analysis and prepared tables and figures. JM designed the health economic component and AC undertook the health economics analysis and wrote corresponding sections under his direction. All authors critically reviewed the protocol and the manuscript and gave approval for the publication.

Financial support

MILESTONE received funding from the European Union's Seventh Framework Programme for research, technological development and demonstration under grant agreement no. 602442. Swaran Singh was supported by the National Institute for Health Research (NIHR) Applied Research Centre (ARC) West Midlands. MILESTONE was sponsored by the University of Warwick.

Role of the funder/sponsor

This paper reflects only the authors' views and the European Union is not liable for any use that may be made of the information contained therein. The funding body has had no role in the study design, in the writing of the protocol or in the decision to submit the paper for publication. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. The sponsor had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the manuscript and decision to submit the manuscript for publication.

Conflict of interest

Frank C. Verhulst is a contributing author of the Achenbach System of Empirically Based Assessments, for which he receives remuneration. Paramala Santosh is the director of HealthTacker Ltd.

Footnotes

*

S.P. Singh and H. Tuomainen contributed equally.

A complete list of the Managing the Link and Strengthening Transition from Child to Adult Mental Health Care (MILESTONE) consortium is provided in the Supplementary material.

References

Achenbach, T., & Rescorla, L. (2001). Manual for the ASEBA school-Age forms & profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth, & Families.Google Scholar
Achenbach, T. M., & Rescorla, L. (2003). Manual for the ASEBA adult forms & profiles: For ages 18–59: Adult self-report and adult behavior checklist. Burlington, VT: ASEBA.Google Scholar
Appleton, R., Connell, C., Fairclough, E., Tuomainen, H., & Singh, S. P. (2019). Outcomes of young people who reach the transition boundary of child and adolescent mental health services: A systematic review. European Child and Adolescent Psychiatry, 28(11), 14311446. doi: 10.1007/s00787-019-01307-7CrossRefGoogle ScholarPubMed
Ballesteros-Urpí, A., Pardo-Hernández, H., Ferrero-Gregori, A., Torralbas-Ortega, J., Puntí-Vidal, J., Tàpies Olivet, P., … Morer, À (2018). Validation of the Spanish and Catalan versions of the health of the nation outcome scale for children and adolescents (HoNOSCA). Psychiatry Research, 261(March), 554559. doi: 10.1016/j.psychres.2017.12.057CrossRefGoogle ScholarPubMed
Birchwood, M. J., Street, C., Singh, S. P., Lamb, C., Anderson, Y., WarnerGale, F., … Upthegrove, R. (2018). Impact and process evaluation of Forward Thinking Birmingham, the 0–25 Mental Health Service: Final Report. University of Warwick; University of Birmingham; GIFT (Great Involvement Future Thinking); CLAHRC-WM.Google Scholar
Cappelli, M., Davidson, S., Racek, J., Leon, S., Vloet, M., Tataryn, K., … Thatte, S. (2016). Transitioning youth into adult mental health and addiction services: An outcomes evaluation of the youth transition project. Journal of Behavioral Health Services & Research, 43(4), 597610. doi: 10.1007/s11414-014-9440-9CrossRefGoogle ScholarPubMed
Chisholm, D., Knapp, M. R. J., Knudsen, H. C., Amaddeo, F., Gaite, L., & Van Wijngaarden, B. (2000). Client socio-demographic and service receipt inventory-European version: Development of an instrument for international research. The British Journal of Psychiatry, 177(39), s28s33. doi: 10.1192/bjp.177.39.s28CrossRefGoogle Scholar
Cleverley, K., Rowland, E., Bennett, K., Jeffs, L., & Gore, D. (2020). Identifying core components and indicators of successful transitions from child to adult mental health services: A scoping review. European Child and Adolescent Psychiatry, 29(2), 107121. doi: 10.1007/s00787-018-1213-1CrossRefGoogle ScholarPubMed
D'Avanzo, B., Lovaglio, P., Parabiaghi, A., Conti, P., Frigerio, A., Molteni, M., … for the Investigators Group. (2018). Health of the Nation Outcome Scales for Children and Adolescents (HoNOSCA): Psychometric properties of the Italian version. Children and Youth Services Review, 94(Nov), 340346. doi: 10.1016/j.childyouth.2018.10.005CrossRefGoogle Scholar
Davis, M., Koroloff, N., Sabella, K., & Sarkis, M. (2018). Crossing the age divide: Cross-age collaboration between programs serving transition-age youth. Journal of Behavioral Health Services & Research, 45(3), 356369. doi: 10.1007/s11414-018-9588-9CrossRefGoogle ScholarPubMed
Garralda, M. E., Yates, P., & Higginson, I. (2000). Child and adolescent mental health service use: HoNOSCA as an outcome measure. The British Journal of Psychiatry, 177(1), 5258. doi: 10.1192/bjp.177.1.52CrossRefGoogle ScholarPubMed
Gowers, S., Levine, W., Bailey-Rogers, S., Shore, A., & Burhouse, E. (2002). Use of a routine, self-report outcome measure (HoNOSCA-SR) in two adolescent mental health services. Health of the nation outcome scale for children and adolescents. The British Journal of Psychiatry, 180, 266269. doi: 10.1192/bjp.180.3.266CrossRefGoogle ScholarPubMed
Gowers, S. G., Harrington, R. C., Whitton, A., Lelliott, P., Beevor, A., Wing, J., & Jezzard, R. (1999). Brief scale for measuring the outcomes of emotional and behavioural disorders in children. Health of the Nation Outcome Scales for children and Adolescents (HoNOSCA). The British Journal of Psychiatry, 174, 413416. doi: 10.1192/bjp.174.5.413CrossRefGoogle ScholarPubMed
Guy, W. (1976). ECDEU assessment manual for psychopharmacology. Rockville, Md.: U.S. Dept. of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration.Google Scholar
Harris, M. G., Sparti, C., Scheurer, R., Coombs, T., Pirkis, J., Ruud, T., … Burgess, P. M. (2018). Measurement properties of the Health of the Nation Outcome Scales (HoNOS) family of measures: Protocol for a systematic review. BMJ Open, 8(4), e021177. doi: 10.1136/bmjopen-2017-021177CrossRefGoogle ScholarPubMed
Hart, L. C., Patel-Nguyen, S. V., Merkley, M. G., & Jonas, D. E. (2019). An evidence map for interventions addressing transition from pediatric to adult care: A systematic review of systematic reviews. Journal of Pediatric Nursing, 48(Sep–Oct), 1834. doi: 10.1016/j.pedn.2019.05.015CrossRefGoogle Scholar
Herdman, M., Gudex, C., Lloyd, A., Janssen, M., Kind, P., Parkin, D., … Badia, X. (2011). Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L). Quality of Life Research, 20(10), 17271736. doi: 10.1007/s11136-011-9903-xCrossRefGoogle ScholarPubMed
Hetrick, S. E., Bailey, A. P., Smith, K. E., Malla, A., Mathias, S., Singh, S. P., … McGorry, P. D. (2017). Integrated (one-stop shop) youth health care: Best available evidence and future directions. The Medical Journal of Australia, 207(10), S5s18. doi: 10.5694/mja17.00694CrossRefGoogle ScholarPubMed
Hovish, K., Weaver, T., Islam, Z., Paul, M., & Singh, S. P. (2012). Transition experiences of mental health service users, parents, and professionals in the United Kingdom: A qualitative study. Psychiatric Rehabilitation Journal, 35(3), 251257. doi: 10.2975/35.3.2012.251.257CrossRefGoogle ScholarPubMed
Leavey, G., McGrellis, S., Forbes, T., Thampi, A., Davidson, G., Rosato, M., … Singh, S. P. (2019). Improving mental health pathways and care for adolescents in transition to adult services (IMPACT): A retrospective case note review of social and clinical determinants of transition. Social Psychiatry and Psychiatric Epidemiology, 54(8), 955963. doi: 10.1007/s00127-019-01684-zCrossRefGoogle ScholarPubMed
Maxwell, S., Ugochukwu, O., Clarke, T., Gee, B., Clarke, E., Westgate, H., … Goodyer, I. M. (2019). The effect of a youth mental health service model on access to secondary mental healthcare for young people aged 14–25 years. BJPsych Bulletin, 43(1), 2731. doi: 10.1192/bjb.2018.70CrossRefGoogle ScholarPubMed
McGorry, P., Bates, T., & Birchwood, M. (2013). Designing youth mental health services for the 21st century: Examples from Australia, Ireland and the UK. The British Journal of Psychiatry Supplement, 202(s54), s30s35. doi: 10.1192/bjp.bp.112.119214CrossRefGoogle Scholar
Moosa, F., & Sandhu, T. (2015). Transition from children's to adult services for patients with ADHD: A model of care. Adolescent Psychiatry, 5(1), 2230. doi: 10.2174/2210676605666150331221509CrossRefGoogle Scholar
Mucci, A., Rucci, P., Rocca, P., Bucci, P., Gibertoni, D., Merlotti, E., … Maj, M. (2014). The specific level of functioning scale: Construct validity, internal consistency and factor structure in a large Italian sample of people with schizophrenia living in the community. Schizophrenia Research, 159(1), 144150. doi: 10.1016/j.schres.2014.07.044CrossRefGoogle Scholar
Paul, M., Ford, T., Kramer, T., Islam, Z., Harley, K., & Singh, S. P. (2013). Transfers and transitions between child and adult mental health services. The British Journal of Psychiatry Supplement, 54, s36s40. doi: 10.1192/bjp.bp.112.119198CrossRefGoogle ScholarPubMed
Paul, M., Street, C., Wheeler, N., & Singh, S. P. (2015). Transition to adult services for young people with mental health needs: A systematic review. Clinical Child Psychology and Psychiatry, 20(3), 436457. doi: 10.1177/1359104514526603CrossRefGoogle ScholarPubMed
Santosh, P., Adams, L., Fiori, F., Davidović, N., de Girolamo, G., Dieleman, G. C., … Singh, S. P. (2020a). Protocol for the development and validation procedure of the managing the link and strengthening transition from child to adult mental health care (MILESTONE) suite of measures. BMC Pediatrics, 20(1). http://dx.doi.org/10.1186/s12887-020-02079-9.CrossRefGoogle ScholarPubMed
Santosh, P., Singh, J., Adams, L., Mastroianni, M., Heaney, N., Lievesley, K., … Singh, S. (2020b). Validation of the transition readiness and appropriateness measure (TRAM) for the managing the link and strengthening transition from child to adult mental healthcare in Europe (MILESTONE) study. BMJ Open, 10(6), e033324. doi: 10.1136/bmjopen-2019-033324CrossRefGoogle ScholarPubMed
Signorini, A., Singh, S., Boričević, V., Dieleman, G., Dodig-Curkovic, K., Franic, T., … for the MILESTONE consortium (2017). Architecture and functioning of child and adolescent mental health services: A 28-country survey in Europe. The Lancet. Psychiatry, 4(9), 715724. doi: 10.1016/S2215-0366(17)30127-XCrossRefGoogle ScholarPubMed
Signorini, G., Singh, S. P., Marsanic, V. B., Dieleman, G., Dodig-Ćurković, K., Franic, T., … Milestone Consortium (2018). The interface between child/adolescent and adult mental health services: Results from a European 28-country survey. European Child and Adolescent Psychiatry, 27(4), 501511. doi: 10.1007/s00787-018-1112-5CrossRefGoogle ScholarPubMed
Singh, S. P., Anderson, B., Liabo, K., & Ganeshamoorthy, T. (2016). Supporting young people in their transition to adults' services: Summary of NICE guidance. BMJ, 353(11 May), i2225. doi: 10.1136/bmj.i2225CrossRefGoogle ScholarPubMed
Singh, S. P., Paul, M., Ford, T., Kramer, T., Weaver, T., McLaren, S., … White, S. (2010). Process, outcome and experience of transition from child to adult mental healthcare: Multiperspective study. The British Journal of Psychiatry, 197(4), 305312. doi: 10.1192/bjp.bp.109.075135CrossRefGoogle ScholarPubMed
Singh, S. P., Tuomainen, H., Girolamo, G. D., Maras, A., Santosh, P., McNicholas, F., … Walker, L. (2017). Protocol for a cohort study of adolescent mental health service users with a nested cluster randomised controlled trial to assess the clinical and cost-effectiveness of managed transition in improving transitions from child to adult mental health services (the MILESTONE study). BMJ Open, 7(10): e016055. 10.1136/bmjopen-2017-016055.Google ScholarPubMed
Skevington, S. M., Lotfy, M., & O'Connell, K. A. (2004). The world health organization's WHOQOL-BREF quality of life assessment: Psychometric properties and results of the international field trial. A report from the WHOQOL group. Quality of Life Research, 13(2), 299310.CrossRefGoogle Scholar
StataCorp (2019). Stata statistical software: Release 16. College Station, TX: StataCorp LLC.Google Scholar
Tatlow-Golden, M., Prihodova, L., Gavin, B., Cullen, W., & McNicholas, F. (2016). What do general practitioners know about ADHD? Attitudes and knowledge among first-contact gatekeepers: Systematic narrative review. BMC Family Practice, 17(129). doi: 10.1186/s12875-016-0516-xCrossRefGoogle ScholarPubMed
Tuomainen, H., Appleton, R., & Singh, S. P. (2020). Care transition from child/adolescents to adult services. In Taylor, E., Verhulst, F. C., Wong, J., Yoshida, K. & Nikapota, A. (Eds.), Mental health and illness of children and adolescents. Singapore: Springer Singapore. doi: 10.1007/978-981-10-0753-8_50-1Google Scholar
Tuomainen, H., Schulze, U., Warwick, J., Paul, M., Dieleman, G. C., Franic, T., … Singh, S. P. (2018). Managing the link and strengthening transition from child to adult mental health care in Europe (MILESTONE): Background, rationale and methodology. BMC Psychiatry, 18(1), 167. doi: 10.1186/s12888-018-1758-zCrossRefGoogle ScholarPubMed
van Staa, A. (2011). Unraveling triadic communication in hospital consultations with adolescents with chronic conditions: The added value of mixed methods research. Patient Education and Counseling, 82(3), 455464. doi: 10.1016/j.pec.2010.12.001CrossRefGoogle ScholarPubMed
van Staa, A., & Sattoe, J. N. (2014). Young adults' experiences and satisfaction with the transfer of care. Journal Adolescent Health, 55(6), 796803. doi: 10.1016/j.jadohealth.2014.06.008CrossRefGoogle ScholarPubMed
Figure 0

Fig. 1. Participant flow through the trial.

Figure 1

Table 1. Baseline characteristics of participants (abridged versiona)

Figure 2

Table 2. Statistical analysis of primary and secondary outcomes 15 months after entry to the study

Figure 3

Table 3. Summary of other secondary outcomes 15 months after entry to the studya

Supplementary material: File

Singh et al. supplementary material

Singh et al. supplementary material

Download Singh et al. supplementary material(File)
File 2.2 MB