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Association between dietary fatty acids and depressive symptoms in Chinese haemodialysis patients: a cross-sectional study

Published online by Cambridge University Press:  15 October 2024

Shuang Zhang ,
Shu-Xin Liu Open the ORCID record for Shu-Xin Liu [Opens in a new window] ,
Qi-Jun Wu ,
Zhi-Hong Wang ,
Hong Liu ,
Ping Xiao ,
Yan Lu ,
Cui Dong  and
Qing-Mei Meng
Shuang Zhang
Affiliation:
Department of Nephrology, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning 116033, People’s Republic of China Dalian Key Laboratory of Intelligent Blood Purification, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning 116033, People’s Republic of China
Shu-Xin Liu*
Affiliation:
Department of Nephrology, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning 116033, People’s Republic of China Dalian Key Laboratory of Intelligent Blood Purification, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning 116033, People’s Republic of China
Qi-Jun Wu
Affiliation:
Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, People’s Republic of China
Zhi-Hong Wang
Affiliation:
Department of Nephrology, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning 116033, People’s Republic of China Dalian Key Laboratory of Intelligent Blood Purification, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning 116033, People’s Republic of China
Hong Liu
Affiliation:
Department of Nephrology, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning 116033, People’s Republic of China Dalian Key Laboratory of Intelligent Blood Purification, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning 116033, People’s Republic of China
Ping Xiao
Affiliation:
Department of Nephrology, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning 116033, People’s Republic of China Dalian Key Laboratory of Intelligent Blood Purification, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning 116033, People’s Republic of China
Yan Lu
Affiliation:
Department of Nephrology, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning 116033, People’s Republic of China Dalian Key Laboratory of Intelligent Blood Purification, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning 116033, People’s Republic of China
Cui Dong
Affiliation:
Department of Nephrology, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning 116033, People’s Republic of China Dalian Key Laboratory of Intelligent Blood Purification, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning 116033, People’s Republic of China
Qing-Mei Meng
Affiliation:
Department of Nephrology, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning 116033, People’s Republic of China Dalian Key Laboratory of Intelligent Blood Purification, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning 116033, People’s Republic of China
*
*Corresponding author: Shu-Xin Liu, email root8848@sina.com
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Abstract

Depression is highly prevalent in haemodialysis patients, and diet might play an important role. Therefore, we conducted this cross-sectional study to determine the association between dietary fatty acids (FA) consumption and the prevalence of depression in maintenance haemodialysis (MHD) patients. Dietary intake was assessed using a validated FFQ between December 2021 and January 2022. The daily intake of dietary FA was categorised into three groups, and the lowest tertile was used as the reference category. Depression was assessed using the Patient Health Questionnaire-9. Logistic regression and restricted cubic spline (RCS) models were applied to assess the relationship between dietary FA intake and the prevalence of depression. As a result, after adjustment for potential confounders, a higher intake of total FA [odds ratio (OR)T3 vs. T1 = 1·59, 95 % confidence interval (CI) = 1·04, 2·46] and saturated fatty acids (SFA) (ORT3 vs. T1 = 1·83, 95 % CI = 1·19, 2·84) was associated with a higher prevalence of depressive symptoms. Significant positive linear trends were also observed (P < 0·05) except for SFA intake. Similarly, the prevalence of depression in MHD patients increased by 20% (OR = 1.20, 95% CI = 1.01–1.43) for each standard deviation increment in SFA intake. RCS analysis indicated an inverse U-shaped correlation between SFA and depression (Pnonlinear > 0·05). Additionally, the sensitivity analysis produced similar results. Furthermore, no statistically significant association was observed in the subgroup analysis with significant interaction. In conclusion, higher total dietary FA and SFA were positively associated with depressive symptoms among MHD patients. These findings inform future research exploring potential mechanism underlying the association between dietary FA and depressive symptoms in MHD patients.

Keywords

Cross-sectional studyDietary fatty acidsDepressive symptomsHaemodialysis
Type
Research Article
Information
British Journal of Nutrition , Volume 132 , Issue 7 , 14 October 2024 , pp. 935 - 945
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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