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ABSORPTION AND DISTRIBUTION OF ULTRATRACE EXOGENOUS 14C UREA IN RATS

Published online by Cambridge University Press:  16 May 2024

Li Wang ,
Hongtao Shen Open the ORCID record for Hongtao Shen [Opens in a new window] ,
Junsen Tang ,
Guofeng Zhang ,
Linjie Qi ,
Dingxiong Chen ,
Kaiyong Wu ,
Xinyi Han ,
He Ouyang  and
Yun He
...Show all authors
Li Wang
Affiliation:
Guangxi Key Laboratory of Nuclear Physics and Technology, Guangxi Normal University, Guilin 541004, China School of Physics, Hubei University, Wuhan Hubei 430062, China
Hongtao Shen*
Affiliation:
Guangxi Key Laboratory of Nuclear Physics and Technology, Guangxi Normal University, Guilin 541004, China
Junsen Tang
Affiliation:
Guangxi Key Laboratory of Nuclear Physics and Technology, Guangxi Normal University, Guilin 541004, China
Guofeng Zhang
Affiliation:
Guangxi Key Laboratory of Nuclear Physics and Technology, Guangxi Normal University, Guilin 541004, China
Linjie Qi
Affiliation:
Guangxi Key Laboratory of Nuclear Physics and Technology, Guangxi Normal University, Guilin 541004, China
Dingxiong Chen
Affiliation:
Guangxi Key Laboratory of Nuclear Physics and Technology, Guangxi Normal University, Guilin 541004, China
Kaiyong Wu
Affiliation:
Guangxi Key Laboratory of Nuclear Physics and Technology, Guangxi Normal University, Guilin 541004, China
Xinyi Han
Affiliation:
Guangxi Key Laboratory of Nuclear Physics and Technology, Guangxi Normal University, Guilin 541004, China
He Ouyang
Affiliation:
Guangxi Key Laboratory of Nuclear Physics and Technology, Guangxi Normal University, Guilin 541004, China
Yun He
Affiliation:
Guangxi Key Laboratory of Nuclear Physics and Technology, Guangxi Normal University, Guilin 541004, China
Pucheng Yang
Affiliation:
Guilin Medical University, Guilin 541004, China
Xue Zhang
Affiliation:
Guilin Medical University, Guilin 541004, China
Chunbo Xia
Affiliation:
Guilin Medical University, Guilin 541004, China
*
*Corresponding author. Email: shenht@gxnu.edu.cn
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Abstract

The absorption and distribution of radiocarbon-labeled urea at the ultratrace level were investigated with a 14C-AMS biotracer method. The radiopharmaceutical concentrations in the plasma, heart, liver, spleen, lung, kidney, stomach, brain, bladder, muscle, testis, and fat of rats after oral administration of 14C urea at ultratrace doses were determined by AMS, and the concentration-time curves in plasma and tissues and pharmacokinetic distribution data were obtained. This study provides an analytical method for the pharmacokinetic parameters and tissue distribution of exogenous urea in rats at ultratrace doses and explores the feasibility of evaluation and long-term tracking of ultratrace doses of drugs with AMS.

Keywords

accelerator mass spectrometry14C ureadistributionpharmacokineticsultratrace
Type
Conference Paper
Information
Radiocarbon , Volume 66 , Issue 5: 24th Radiocarbon and 10th 14C & Archaeology, Zurich, Sept. 11–16, 2022 Proceedings Part 1 of 2 , October 2024 , pp. 1450 - 1459
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of University of Arizona

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Footnotes

Selected Papers from the 24th Radiocarbon and 10th Radiocarbon & Archaeology International Conferences, Zurich, Switzerland, 11–16 Sept. 2022.

References

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