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1 results

  • Increased GABAA receptor binding in amygdala after prenatal administration of valproic acid to rats

  • Freja Bertelsen, Arne Møller, Davide Folloni, Kim Ryun Drasbek, Jørgen Scheel-Krüger, Anne M. Landau
  • Journal:
    Acta Neuropsychiatrica / Volume 29 / Issue 5 / October 2017
    Published online by Cambridge University Press:
    12 December 2016, pp. 309-314
  • Objective

    Prenatal exposure to valproic acid (VPA) enhances the risk for later development of autism spectrum disorders (ASD). An altered gamma-aminobutyric acid (GABA) system may be a key factor in ASD. Here we investigated possible changes in the GABA system in rats exposed to a low dose of prenatal VPA.

    Method

    We performed autoradiography with [3H]muscimol, (a GABAA receptor agonist), and [11C]Ro15-4513 (a partial agonist of the GABAA α1+5 receptor subtypes), in brain sections containing amygdala, thalamus and hippocampus of rats treated prenatally with 20 mg/kg VPA or saline from the 12th day of gestation.

    Result

    Prenatal VPA significantly increased [11C]Ro15-4513 binding in the left amygdala compared with controls (p<0.05). This difference was not observed in the hippocampus, thalamus or right amygdala. No differences were observed in [3H]muscimol binding.

    Conclusion

    We observed an asymmetric increase in GABAA receptor binding. Disturbances in the GABAA receptor system have also been detected in human autism with [11C]Ro15-4513.