The Flowers River Igneous Suite of north-central Labrador comprises several discrete peralkaline granite ring intrusions and their coeval volcanic succession. The Flowers River Granite was emplaced into Mesoproterozoic-age anorthosite–mangerite–charnockite–granite (AMCG) -affinity rocks at the southernmost extent of the Nain Plutonic Suite coastal lineament batholith. New U–Pb zircon geochronology is presented to clarify the timing and relationships among the igneous associations exposed in the region. Fayalite-bearing AMCG granitoids in the region record ages of 1290 ± 3 Ma, whereas the Flowers River Granite yields an age of 1281 ± 3 Ma. Volcanism occurred in three discrete events, two of which coincided with emplacement of the AMCG and Flowers River suites, respectively. Shared geochemical affinities suggest that each generation of volcanic rocks was derived from its coeval intrusive suite. The third volcanic event occurred at 1271 ± 3 Ma, and its products bear a broad geochemical resemblance to the second phase of volcanism. The surrounding AMCG-affinity ferrodiorites and fayalite-bearing granitoids display moderately enriched major- and trace-element signatures relative to equivalent lithologies found elsewhere in the Nain Plutonic Suite. Trace-element compositions also support a relationship between the Flowers River Granite and its AMCG-affinity host rocks, most likely via delayed partial melting of residual parental material in the lower crust. Enrichment manifested only in the southernmost part of the Nain Plutonic Suite as a result of its relative proximity to multiple Palaeoproterozoic tectonic boundaries. Repeated exposure to subduction-derived metasomatic fluids created a persistent region of enrichment in the underlying lithospheric mantle that was tapped during later melt generation, producing multiple successive moderately to strongly enriched magmatic episodes.