Work-related conditionality policy in the UK is built around the problematic assumption that people should commit to ‘full-time’ work and job search efforts as a condition of receiving benefits. This is potentially in conflict with the idea that what is required of people should be tailored to their circumstances in some way – ‘personalised conditionality’ – and implies a failure to recognise that conditionality is being applied to a diverse group of people and in a context where the paid work that is available is often temporary and insecure. Drawing on thirty-three qualitative interviews with people subject to intensive work-related conditionality whilst receiving Universal Credit or Jobseeker’s Allowance in Manchester, the paper explores the work-related time demands that people were facing and argues that these provide a lens for examining the rigidities and contradictions of conditionality policy. The findings indicate that expectations are often set in relation to an ideal of full-time hours and in a highly asymmetric context that is far from conducive to being able to negotiate a reasonable set of work-related expectations. Work search requirements affect people differently depending on their personal circumstances and demand-side factors, and can act to weaken the position of people entering, or already in, work.

In the search for new applications of natural silicates, various F− treatments have been applied to sepiolite to increase its acidic properties and for use as a catalyst in reactions occurring via carbonium ions. Two types of treatments including hydrofluoric acid (HF) at different concentrations and 2 N NH4F have been utilized and the physicochemical characteristics of the resulting materials studied using standard techniques. The X-ray diffractogram (XRD) patterns indicate a decrease in crystallinity of the original material as well as the appearance of amorphous silica. SEM micrographs showed a shortening and aggregation of the sepiolitic fibers. X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR), thermogravimetric analysis/differential thermal analysis (TGA/DTA), N2 adsorption-desorption isotherms and Hg intrusion were used to study the changes occurring in the structure, surface area and pore distribution of samples and acidity was evaluated by IR and thermoprogrammed desorption (TPD) of adsorbed ammonia and pyridine. It was found that acidity increased in most of the samples after anionic and cationic interchange between the activating agents and the surface sites, or extralattice cations. Additionally, structural changes induced by treatments modified the Brönsted and Lewis acidity. Mild treatments with ammonium fluoride are more effective than HF treatments in acidity generation.

Activation schemes are widely criticised, with the negative experiences of ‘the activated’ featuring prominently in the literature. This article presents the findings of a constructivist grounded theory study concerning the lived experience of long-term unemployment, welfare recipiency and community placement in activation schemes in Ireland, with a focus on the positive effects that participating in such schemes had on participants’ subjective well-being. For the participants in this research, community placement signified change, respite, and recovery that improved their subjective well-being by creating an experience that counteracted the draining experience of long-term unemployment and welfare recipiency. This study brings new elements to the discussion on the role of activation in promoting/diminishing the subjective well-being of the long-term unemployed.

In order to develop high-performance adsorbents to remove toxic methylene blue (MB) from wastewater, palygorskite (Plg) was utilized as a template to prepare palygorskite/carbon (Plg/C) composites by using a hydrothermal reaction in the presence of glucose. The porous Plg/C composites were then activated with ZnCl2. The effects of the dose of the activator and the activation temperature on the crystal structure, micro-morphology, specific surface area, and adsorption performance of the porous Plg/C composites were studied systematically here. X-ray diffraction (XRD) and scanning electron microscopy (SEM) results indicated that the crystal structure of Plg was destroyed during the activation process and irregular porous carbon was closely attached to the residual aluminosilicate skeleton. The activation was optimized at 400°C with a ZnCl2:Plg/C impregnation ratio of 2:1. The sample had a specific surface area of 1497.88 m2/g, together with a total pore volume and micropore volume of 1.0355 and 0.5464 cm3/g, respectively. The MB adsorption capacity was 381.04 mg/g. Such inexpensive, high-performance, porous Plg/C composites could find potential applications in wastewater treatment.

When we think about emotional ambiguity, we usually think about the feeling of ambivalence. However, in a recently proposed model, ambiguity might also be present in different emotional spaces, such as origin (dimensions of automaticity and reflectiveness) and activation (arousal and subjective significance) as proposed in the basics of dual-process theories. In two experiments, we checked for behavioural and psychophysical differences in processing words of origin and activation ambiguities while completing an emotionality rating task. In Experiment 1, we assessed emotionality ratings and reaction times; in Experiment 2, we used a webcam-based eye-tracking measurement to assess the number and mean duration of fixations. We found significant effects for words differing in origin and activation: the emotionality ratings increased within the intensity of origin ambiguity but decreased within the intensity of activation ambiguity; more and longer fixations were registered for words of higher origin ambiguity; and gradually fewer and shorter fixations were registered within increases in activation ambiguity. We found that the ambiguities on spaces of origin and activation produced their own main effects, but they also factored significantly into the interaction, modifying each other’s results. Our study is the first to show specifics of the perception of ambiguous stimuli on spaces other than valence.

This article explores the accountability experiences and orientations of frontline workers implementing personalised activation services in the Norwegian Labour and Welfare Administration (NAV). The study draws on observations and interviews (2021), with three teams of employment specialists using Supported Employment as an approach to personalised service provision, in a national programme called Extended Follow-up. Adopting the theoretical lens of accountability as behaviours of account giving, three strategies on how to adopt the accountability regime at the frontline are highlighted: (i) reporting, where one team complied with accountability requirements as the perceived best practices for achieving success in work inclusion; (ii) mitigating, where accountability requirements were fulfilled but combined with attention to how to best meet jobseekers’ needs; and (iii) reframing, where accountability requirements were challenged and redefined. The study highlights how accountability requirements may be interpreted variably, promoting personalised service innovation on the one hand or stagnation on the other.

Public health measures to address the COVID-19 pandemic have disrupted welfare regimes around the world. The Australian government suspended activation requirements for millions of social security clients and substantially increased payment levels. Both measures go against the dominant policy logic over the past several decades in Australian social policy. When these changes were made, many advocates and academics called for a permanent increase in the rate of payment and a relaxation of activations requirements. The Australian Government insisted the stimulus package was temporary and that there would be a gradual return to the pre-pandemic policy settings. In this article, we examine what was learned during this natural experiment of unconditional higher payments, which temporarily lifted millions of households out of poverty. We argue that a return to pre-pandemic policy settings should not go unchecked as there remains an opportunity to consider alternative approaches to the welfare-work nexus in Australia.

This article aims to bring labour market activation policy into the orbit of eco-social policy, which we can understand as sustainable welfare without growth. Activation is extensively addressed from economic and social policy perspectives; however, environmental sustainability concerns are absent. Typically, each domain, activation and sustainability, is seen as mutually exclusive. Growing debate about sustainable welfare without growth features much discussion about the effects of productivism and about re-orienting and re-valuing work and how we use our time; however, such discussion tends to leave activation and unemployment untouched. One could ask whether there is any role for activation in eco-social policy: why focus on employment and employability, or even push people into work, if postgrowth requires a downsizing of paid employment and working time in everyone’s lives? The purpose of this article is to explore this question and to consider how activation could be re-valued and re-thought as a policy tool for eco-social policy.

Viruses completely rely on the energy and metabolic systems of host cells for life activities. Viral infections usually lead to cytopathic effects and host diseases. To date, there are still no specific clinical vaccines or drugs against most viral infections. Therefore, understanding the molecular and cellular mechanisms of viral infections is of great significance to prevent and treat viral diseases. A variety of viral infections are related to the p38 MAPK signalling pathway, and p38 is an important host factor in virus-infected cells. Here, we introduce the different signalling pathways of p38 activation and then summarise how different viruses induce p38 phosphorylation. Finally, we provide a general summary of the effect of p38 activation on virus replication. Our review provides integrated data on p38 activation and viral infections and describes the potential application of targeting p38 as an antiviral strategy.

Job search is a central element of activation policies, which aim to transform unemployed people into active jobseekers who are subject to checks. We examine a neglected aspect of activation: sanctions. To do so we analyse, through biographical interviews with formerly-unemployed people whose benefit payments have been stopped, what it means when a job search is deemed insufficient. Although these formerly-unemployed people have failed to present enough written and tangible evidence of their job search during checks, they have pursued a different type of job search comprising more informal activities that are difficult to convert into written documents. So, we identify a twin-stranded job search – prescribed and alternative. We also point out that the gap between institutionally-framed job search and experience-based job search widens among unemployed people having low employability attributes, so that ever-stricter checks penalize those who are most vulnerable.

While there has been much research on welfare exit and entry into employment, less research has looked at return to government assistance. Applying survival analysis on data from a national government assistance programme in Singapore, we found two important factors of welfare return to which activation programmes need to pay greater attention. First, return was more likely if former beneficiaries accumulated a higher number of types of arrears rather than higher dollar values of arrears. This new finding contributes to the emerging literature on bandwidth tax, and suggests the importance of designing programmes that relieve mental accounting due to debt and poverty. Second, return was more likely if respondents had an infant or toddler child. This points to the importance of a range of support policies including affordable and accessible childcare, exemption from work requirement in receipt of welfare, and family leave for low-wage workers.

There is an increasing emphasis on activating workers on sick leave and on using their residual work capacity. This article compares activation via graded-work schemes in Germany, Austria, Switzerland and the Netherlands, with a focus on the role of employers. The analysis of literature sources and survey data reveals an ongoing reform activity, as well as great diversity in terms of employer obligations and incentives in the countries studied. These differences are very consequential for the intensity of employer efforts to activate sick-listed workers, even when comparing countries that otherwise share many institutional features. The distinction between public and privatised systems of sickness insurance, on the contrary, seems to be less relevant for the question of employer participation in activation. The findings are consistent with the expectation that less comprehensive employer participation is correlated with stronger selectivity in activation efforts. Depending on the prevailing approach in the individual countries and on developments to date, policy-makers are confronted with different challenges and priorities.

The purpose of this study is to analyse determinants of resources devoted to public employment services (PES). It has proven difficult to disentangle ‘carrots’ (placement and services) from ‘sticks’ (sanctions and monitoring) when tracking the development of PES spending. This has contributed to ambivalence concerning the role of partisan politics, especially since welfare states have been argued to increasingly emphasize the ‘sticks’ aspect of the PES, irrespective of ideological orientation. This suggests that the role of partisan politics should be analysed together with ‘demanding’ activation, which is made possible with novel data on unemployment benefit conditionality. The analysis includes 16 welfare states and results indicate that left and secular centre-right parties are associated with increased resources devoted to PES, but that effects of partisan politics are contingent on the form and extent of benefit conditionality. Increased conditionality is associated with higher PES spending, thus nuancing the cost-containment argument for activation.

La dimension thymique est souvent considérée – à juste titre – comme centrale dans les différentes phases observées dans les troubles bipolaires de l’humeur. Mais au-delà, une autre dimension, plus psychomotrice, apparaît comme un outil de description sémiologique des états dépressifs, (hypo)manes et mixtes et des phases dites de rémission. La mesure de cette dimension psychomotrice peut faire appel à des questionnaires, des tests neuropsychologiques ou des outils d’utilisation plus récente dans le domaine des troubles bipolaires comme l’actigraphie par exemple. Nous montrerons que ces différents outils permettent de modéliser les différents états de la pathologie comme des défauts d’inhibition/activation avec différents outputs comportementaux ou cognitifs. Ces mesures permettraient par exemple de distinguer les dépressions « pures » anergiques/hypo-actives des dépressions avec composante de mixité, toutes deux observées dans le cours évolutif des troubles bipolaires. Elles permettraient aussi potentiellement d’orienter le diagnostic vers des troubles unipolaires ou d’identifier des dimensions de bipolarité. Enfin, ces dimensions d’inhibition/activation pourraient relancer le débat autour de la place centrale de la dopamine comme ces différents états des troubles bipolaires. Certains modèles récents proposent notamment la notion de « déplétion soudaine » en dopamine pour expliquer les transitions entre divers états des troubles bipolaires, caractérisés pour les uns par le ralentissement psychomoteur et ou les autres par une sur-activation psychomotrice. Nous ouvrirons les perspectives sur les possibles usages des agonistes dopaminergiques dans la prise en charge des dépressions bipolaires, alors que ces traitements ont été jusqu’à récemment considérés comme contre-indiqués du fait des risques d’inversion de l’humeur.

Objectives. – Studies on the relation between local cerebral activation and retrieval success usually compared high and low performance conditions, and thus showed performance-related activation of different brain areas. Only a few studies directly compared signal intensities of different response categories during retrieval. During verbal recognition, we recently observed increased parieto-occipital activation related to false alarms. The present study intends to replicate and extend this observation by investigating common and differential activation by veridical and false recognition.

Methods. – Fifteen healthy volunteers performed a verbal recognition paradigm using 160 learned target and 160 new distracter words. The subjects had to indicate whether they had learned the word before or not. Echo-planar MRI of blood-oxygen-level-dependent signal changes was performed during this recognition task. Words were classified post hoc according to the subjects’ responses, i.e. hits, false alarms, correct rejections and misses. Response-related fMRI-analysis was used to compare activation associated with the subjects’ recognition success, i.e. signal intensities related to the presentation of words were compared by the above-mentioned four response types.

Results. – During recognition, all word categories showed increased bilateral activation of the inferior frontal gyrus, the inferior temporal gyrus, the occipital lobe and the brainstem in comparison with the control condition. Hits and false alarms activated several areas including the left medial and lateral parieto-occipital cortex in comparison with subjectively unknown items, i.e. correct rejections and misses. Hits showed more pronounced activation in the medial, false alarms in the lateral parts of the left parieto-occipital cortex.

Conclusions. – Veridical and false recognition show common as well as different areas of cerebral activation in the left parieto-occipital lobe: increased activation of the medial parietal cortex by hits may correspond to true recognition, increased activation of the parieto-occipital cortex by false alarms may correspond to familiarity decisions. Further studies are needed to investigate the reasons for false decisions in healthy subjects and patients with memory problems.