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2 results

  • Chapter 1 - Routine Prenatal Care

  • from Section 1 - Obstetric Aspects of Antenatal Care
  • Edited by Amira El-Messidi, McGill University, Montréal, Alan D. Cameron, University of Glasgow
  • Book:
    OSCEs in Obstetrics and Maternal-Fetal Medicine
    Published online:
    23 February 2023
    Print publication:
    16 February 2023, pp 3-21
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  • Summary

    A 27-year-old primigravida at 11+1 weeks’ gestation by menstrual dating presents for her first visit for routine prenatal care, accompanied by her husband. While discussing the comprehensive medical history with you before you meet the couple, your obstetric trainee mentions that the patient is allergic to penicillin.

  • 12 - Non-invasive prenatal diagnosis for fetal blood group status

  • Edited by Sean Kehoe, Lyn Chitty, Tessa Homfray
  • Book:
    Reproductive Genetics
    Published online:
    05 February 2014
    Print publication:
    01 November 2009, pp 173-182

  • Summary

    A problem in all tests on fetal DNA derived from maternal plasma arises from the large quantity of maternal DNA present in the DNA preparation, complicating the inclusion of satisfactory internal controls to test for successful amplification of the fetal DNA. As increasing number of laboratories internationally are introducing non-invasive fetal blood group testing, it is important that their performances are monitored through external quality assurance schemes. Fetal RHD screening provides a way of significantly reducing the quantity of blood products given routinely to pregnant women. To date, the enormous promise of the application of free fetal DNA in maternal plasma to prenatal diagnostics has only been realised in fetal blood grouping and fetal sexing. Fetal blood grouping often plays an important role in avoidance of unnecessary procedures and is the standard of care in England for pregnant women with significant level of anti-D immunoglobulin.