An improved method of space-time conservation element and solution element (CE/SE) is developed to solve the equations of conservation laws in fluid dynamics. The present method substantially differs in both concept and methodology from the traditional CE/SE method. In this paper the improved second-order CE/SE method is presented in a hexahedral grid. Furthermore, the present CE/SE method was successfully applied to solve the interaction problem of shock waves and detonation. Several numerical examples were also given. Numerical results have compared with the results of experiments and other computational methods. The compared results have shown a good agreement. The improved CE/SE method has higher accuracy and becomes a more prospective scheme.