Three typical cokes were used for experiments in order to clarify the relationship between coke properties and solution loss behavior and its influence on the post-reaction strength of coke. Isothermal reactions between coke and CO2 at 1050–1300 °C were stopped at a weight loss of 25%. The post-reaction strength of coke was tested by an I-Type tumbler. Coke chemical reactivity and pore structure were tested to analyze the coke properties. The results show that the reaction temperature caused the most serious degradation to three cokes that were different due to their different properties. If two kinds of coke have similar chemical reactivity, the one with the less developed pore structure has a lower temperature, causing the most serious degradation. If two kinds of coke have similar pore structure, the one with the higher chemical reactivity has a lower temperature, causing the most serious degradation. This knowledge contributes to a reference for evaluating the capability of coke strength for resisting solution loss.