A random mail survey of Ohio growers was conducted to determine the geographic distribution of weeds across Ohio and the influence of production practices on the severity of agronomic weed problems. Statewide, the ten most severe weed problems, in descending order, were Canada thistle > foxtail spp. > velvetleaf = common ragweed > common cocklebur > giant ragweed = annual morningglory spp. > quackgrass = common lambsquarters = Pennsylvania smartweed. Distribution of most weeds varied geographically. Infestations of common and honeyvine milkweeds, hemp dogbane, and tree seedlings increased as tillage was reduced. Infestations of common cocklebur and common ragweed decreased as tillage was reduced. As crop rotation became more diverse, infestations of velvetleaf, common cocklebur, giant ragweed, Pennsylvania smartweed, and jimsonweed decreased. Where rotations included forage or hay crops, infestations of large crabgrass, common chickweed, wild carrot, and common dandelion increased.