Based on the coordinate transformation method, the formula of the dynamic inhomogeneous isoparametric finite element method is presented for generating element stiffness, damping and mass matrices. First, the global coordinate form and simplified form of dynamic inhomogeneous finite element are given in this paper. Then, the discrete material parameter distributions under the isoparametric coordinate system are obtained by using the transformation relationship between the global coordinates and the isoparametric coordinates. The simplified form with the discrete material parameter distributions is obtained for generating the element stiffness and mass matrices of the dynamic inhomogeneous isoparametric element. The numerical examples show that the scheme proposed in present paper has high precision.