In a multiple (or multivariate) regression model where the predictors are subject to errors of measurement with a known variance-covariance structure, two-sample hypotheses are formulated for (i) equality of regressions on true scores and (ii) equality of residual variances (or covariance matrices) after regression on true scores. The hypotheses are tested using a large-sample procedure based on maximum likelihood estimators. Formulas for the test statistic are presented; these may be avoided in practice by using a general purpose computer program. The procedure has been applied to a comparison of learning in high schools using achievement test data.