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1 results

  • Light-induced GTPase activity and GTP[γS] binding in squid retinal photoreceptors

  • Joel E. Brown, Anthony Combs, Karen Ackermann, Craig C. Malbon
  • Journal:
    Visual Neuroscience / Volume 7 / Issue 6 / December 1991
    Published online by Cambridge University Press:
    02 June 2009, pp. 589-595

  • Illumination greatly increases the GTPase activity in homogenates of squid (Loligo) whole retinas or rhabdomeric membranes. Adenylylimidodiphosphate inhibits the light-insensitive (but not the light-sensitive) GTPase activity in these homogenates. Illumination also greatly increases the binding of GTP[γS] to the rhabdomeric membranes. This binding at saturating illuminations indicates that there are approximately 10–100 times more rhodopsin molecules than G-protein molecules in squid photoreceptors. Each light-activated rhodopsin molecule activates about 10 G-protein molecules which might provide amplification for the first stage of the phototransduction cascade.