A novel coplanar waveguide-fed Z-monopole antennas are proposed for the first time for a industrial, scientific, and medical (ISM) band (2.4–2.48 GHz) applications. To make the designed antenna suitable for implantation, it is embedded in biocompatible Al2O3 ceramic substrate. The antenna operates at resonance frequency of 2.45 GHz to support wide band communication for high data rate implantable neural monitoring application. The size of the antenna is 38.675 mm3 (8.5 mm × 7 mm × 0.65 mm). The antenna was simulated and measured by immersing it in a phantom liquid, imitate the electrical properties of the human body phantom liquid. The simulated and measured bandwidths are 10.2 and 11.4% at the centre frequency. A study of the sensitivity of the antenna performance as a function of its dielectric parameters of the environment in which it is immersed was performed. The demonstration among the design EM characteristics of the antenna is presented by current distributions.
