We developed a high-resolution magnetochronology of the Pleistocene stratigraphy of the Monte Netto hillock, a tectonically uplifted structure in the Po Plain of northern Italy. Our data allowed reconstructing the depositional age of the sequence and assessing rates of deformation and rock uplift of the neotectonic structure, thus providing constraints on the tectono-sedimentary evolution of this seismically active part of the buried Southern Alps. Using a combination of magnetostratigraphy and paleosecular variation analysis, we generated an age-depth model for the Monte Netto stratigraphy that encompasses, from the top, Upper Pleistocene (11–72 ka) loess-paleosols overlaying fluvial sediments spanning the Brunhes-Matuyama boundary (773 ka) and the top of the Jaramillo (990 ka). The identification of the same magneto-chronostratigraphic surfaces in nearby drill cores from regions of the Po Plain that have not been affected by neotectonic deformation allowed estimating a mean rate of tectonic uplift of the hillock relative to the neighboring plain of 11.3 ± 1.5 cm/ka, and an absolute uplift relative to sea level of ~19.3 cm/ka. Finally, our paleomagnetic analyses from the uppermost loess sequence disclosed the complexity of the tectonic evolution of the Monte Netto structure, which shows evidence of a two-phase rotational deformation linked to coseismic surface faulting due to recent seismic activity.