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1 results

  • Expression of maspin in invasive fungal rhinosinusitis

  • Y D Huang, H W Yu, S W Xia, Z H Kang, Y S He, D Y Han
  • Journal:
    The Journal of Laryngology & Otology / Volume 131 / Issue 2 / February 2017
    Published online by Cambridge University Press:
    29 December 2016, pp. 150-154
    Print publication:
    February 2017
  • Objective:

    This study aimed to test the expression of maspin in invasive fungal rhinosinusitis and explore its value in diagnosing invasive fungal rhinosinusitis.

    Methods:

    Forty-two fungal rhinosinusitis cases (12 invasive and 30 non-invasive) were selected as the experimental group, and 30 chronic rhinosinusitis cases comprised the control group. Maspin expression was assessed in nasal mucous membrane specimens by immunohistochemical staining.

    Results:

    Compared with the control group, maspin expression was down-regulated in the fungal rhinosinusitis group (p < 0.05). Furthermore, the staining score for maspin was lowest in the invasive fungal rhinosinusitis group, as compared with both the non-invasive fungal rhinosinusitis group and the control group (p < 0.05). A maspin staining score of 5.70 was the critical value for diagnosis of invasive fungal rhinosinusitis, with sensitivity and specificity of 91.7 per cent and 88.3 per cent, respectively.

    Conclusion:

    The results of this study suggest that the maspin staining score may be a biomarker for effective and rapid diagnosis of invasive fungal rhinosinusitis.