All militaries try to develop a “winning edge” in warfare. More often than not these attempts focus on new weapons systems and weapons platforms, on new ways of maximizing the offensive capabilities of a military through firepower. These attempts can also involve the training and development of soldiers, including performance enhancements to make them fight better, longer, and smarter than the enemy and to counter human frailty on the battlefield. These concerns and problems have long held the interest of the U.S. military. This article traces the development, rationale, and legacy of one such attempt to deal with human frailty and the “body problem,” a kind of military futurism devised at the peak of the Cold War. Dr. Marion Sulzberger envisioned creating soldiers who had their own kind of special “biological armor,” or what he termed “idiophylaxis.” In 1962, he presented a paper at the Army Science Conference at West Point titled “Progress and Prospects in Idiophylaxis (Built-In Individual Self-Protection of the Combat Soldier).” Sulzberger's call was for a radical rethinking of the combat soldier and the ways in which soldiers were imagined, designed, and developed. His goal was to “armor” the individual soldier both internally and psychologically through new forms of biomedicine and biotechnology. The interventions he detailed in 1962 live on today in the U.S. military's soldier performance enhancement research programs, including DARPA's recent “Inner Armor” program and desire to make “kill-proof” soldiers.