This article analyses the determinants of the quality of life in a sample of 600 people aged 60 or more years living in deprived areas of three English cities. Data were collected by means of a face-to-face administered questionnaire. Two standardised measures, the ‘Satisfaction With Life Scale’ (SWLS) and the ‘Philadelphia Geriatric Center Morale Scale’ (PGCMS), and a single-item question were used to produce outcome measures of the quality of life. Using a conceptual model of quality of life factors, 21 socio-demographic, objective and subjective variables were correlated with each of the measures. Thirteen of these variables were subsequently entered in three multiple regression models. Subjective variables correlated significantly with all three quality of life measures, but socio-demographic and objective life condition variables correlated less strongly. Regression analysis revealed perception of own health, perceived ability to cope financially, perception of poverty over time and loneliness to be important determinants of the quality of life across all three quality of life measures. Variables that described characteristics of the urban environment had limited direct influence on the quality of life. The findings support the conceptual framework and highlight the key role played by subjective variables in determining the quality of life of older people in deprived urban areas.