The central Himalaya can be regarded as an ideal site for developing a long-term ice core dust record to reflect the environmental signals from regional to semi-hemispheric scales. Here we present a dust record from segments of a 108.83-m ice core recovered from the East Rongbuk (ER) Glacier (27°59′N, 86°55′E; 6518 m a.s.l.) on the northeast slope of Mt. Qomolangma (Everest) in the central Himalaya, covering the period AD 600–1960. Due to rapidly layer thinning and coarse sampling, we primarily discuss the changes in the dust record since AD 1500 in this paper. Results show a significant positive relationship between the dust concentration and reconstructed air temperatures during this period, suggesting a likely cold–humid and warm–dry climatic pattern in the dust source regions, namely Central Asia. This is associated with the variability in the strength of the westerlies and its corresponding precipitation.