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A 60-year-old man reported slowly progressive symptoms over a period of five years. He experienced tingling in his toes that gradually spread halfway up the lower legs. He also developed a stiff feeling in his lower legs and nightly cramps in both calves, but no pain. For one year, he complained of numb fingertips with some loss of dexterity. He had no symptoms of autonomic dysfunction, was not known to have diabetes, ate a healthy, balanced diet, drank one glass of alcohol a day, and had not been treated with neurotoxic medication. His family history indicated no other relatives with similar complaints.
A 14-year-old girl born in Brazil who moved to Europe at a young age presented with weakness and a dull feeling in her right hand. The symptoms had been progressive over a period of one year. Initially, she had diminished sensation of her right index finger. This gradually progressed to affect the whole of her right hand, which eventually became numb. She was right-handed and could no longer use a pen for writing. Otherwise, her history was unremarkable.
A 49-year-old man noticed a diminished sensation in his feet. Two months later, climbing stairs became difficult due to proximal muscle weakness of his legs. Over the next three months, sensory disturbances and both proximal and distal weakness progressed in arms and legs requiring the use of a walker or a wheelchair. Besides COPD, he was previously in a healthy condition. Based upon ancillary investigations, he was initially diagnosed with chronic inflammatory demyelinating polyneuropathy (CIDP), had received a course of intravenous Ig (IVIg), and was subsequently treated with high-dose corticosteroids (60 mg/day). He did not smoke or use drugs such as nitric oxide.
A 40-year-old man was referred because he wished to be informed about the genetic nature of his disorder. He was diagnosed with Charcot–Marie–Tooth (CMT) disease. At 14 months of age, he started walking, but awkwardly due to a bilateral drop foot for which braces were prescribed. On first examination at age 2 years and 8 months, there was marked atrophy, hypotonia, and areflexia of the lower legs, and slight wasting of the thenar and hypothenar. At that time, nerve conduction studies showed normal motor conduction velocities of arm nerves. No motor unit action potentials could be recorded in the lower leg muscles on concentric needle examination.
A 20-year-old previously healthy man suddenly noticed that he was unable to run. The next day he could not climb the stairs and lost strength in his arms. He was admitted to hospital, and over the next hours he progressively lost muscle power in his arms and legs. Swallowing was progressively impaired, and he noticed minor tingling in both hands and feet. He had had a minor upper respiratory tract infection a week prior to admission.
A 66-year-old man with slowly progressive tingling and a dull feeling in his feet for two years visited our outpatient clinic. He noticed some imbalance when walking after rising from a chair or from bed. He had no complaints about his hands, and he did not notice weakness. He loved to play golf with his friends several times a week. He was known to have a steatotic liver and hypertension. He did not smoke, but he admitted that he had been drinking six glasses of beer or wine a day for many years. He used anti-hypertensive drugs and vitamin B complex.
A 76-year-old man complained about progressive dull feelings and weakness of the distal lower limbs that gradually progressed over a couple of months to the proximal legs and the hands. In addition, there was minor myalgia in the proximal muscles. He had had a myocardial infarction with cardiac arrhythmia three years earlier. He was treated with amiodarone afterwards. He did not have visual complaints and was otherwise healthy. He did not drink alcohol or use other drugs. He had not been treated with cytostatic drugs.
A 73-year-old-woman noticed pain in her right lower leg and thigh and left foot. After a few weeks of physiotherapy, she gradually developed tingling in her feet and a ‘plastic’ sensation in the soles of her feet. A few weeks later, her feet became completely numb, and she noticed painful tingling in her hands and around her left knee. Because of the tingling in her hands, she could barely use a fork and knife. Walking became difficult due to the dull feelings in her legs. Several drugs against painful neuropathy did not help. For years she had smoked two packs of cigarettes a week. A total of 50 pack-years was estimated.
A previously healthy, very active 68-year-old man, who usually cycled over 100 km several times a week, noticed progressive tingling in his feet and lower legs that increased over several weeks. This was followed by progressive weakness in the arms and legs exceeding a period of eight weeks. After three months of progression, weakness became so severe that he could not even walk without help. He did not use drugs or drink alcohol.
A 62-year-old man reported slowly progressive symptoms over a period of two years. He could no longer walk steadily and developed numb feelings on the soles of both feet and a tremor of both hands. He was not known to have diabetes and ate a healthy, balanced diet, drank one glass of alcohol a day, and had not been treated with neurotoxic medication.
A 24-year-old woman had difficulty with walking since early childhood. At age 18 months she was able to walk without support. She often stumbled and could not keep up with her peers in gym class. However, she still had been able to walk 5 km during a four-day walking event. Management included physiotherapy, and she had orthopaedic shoes. She underwent surgery at age eight years (tendon repositions of both feet). Family history was not available because she was adopted. Previous history includes bilateral congenital hip dysplasia and congenital hypothyroidism.
An attempt was made to develop a novel dairy-based dip-like product from heat-acid-induced milk gel and whey. Based upon preliminary trials, the combination of cream (15–35%), whey (60–70%) and common salt (0.8–1.0%, all three as weight of heat-acid-induced milk gel) was selected for optimization of the dairy dip through factorial design of response surface methodology (RSM). Addition of glycerol monostearate, trisodium citrate and sodium hexametaphosphate each at the rate of 0.3% (as weight of heat-acid-induced milk gel) in the formulation was previously standardized. The optimization was carried out by analysing the textural and sensorial parameters of the dairy-based dip. The sensorial parameters (flavour, body and texture, colour and appearance and overall acceptability) and textural parameters (firmness, stickiness, work of shear and work of adhesion) were significantly (P < 0.05) correlated with the ingredient formulation. RSM analysis suggested the use of cream, whey and common salt at amounts of 27.92, 60.26 and 0.8% of the weight of heat-acid-induced milk gel for preparing dairy-based dip with a desirability of 0.84. The formulated product contained a lower fat but higher protein and lactose content than cheese dip.
Sensory differences and anxiety disorders are highly prevalent in autistic individuals with and without ADHD. Studies have shown that sensory differences and anxiety are associated and that intolerance of uncertainty (IU) plays an important role in this relationship. However, it is unclear as to how different levels of the sensory processing pathway (i.e., perceptual, affective, or behavioral) contribute. Here, we used psychophysics to assess how alterations in tactile perception contribute to questionnaire measures of sensory reactivity, IU, and anxiety. Thirty-eight autistic children (aged 8-12 years; 27 with co-occurring ADHD) were included. Consistent with previous findings, mediation analyses showed that child-reported IU fully mediated an association between parent-reported sensory reactivity and parent-reported anxiety and that anxiety partially mediated an association between sensory reactivity and IU. Of the vibrotactile thresholds, only simultaneous frequency discrimination (SFD) thresholds correlated with sensory reactivity. Interestingly, we found that sensory reactivity fully mediated an association between SFD threshold and anxiety, and between SFD threshold and IU. Taken together, those findings suggest a mechanistic pathway whereby tactile perceptual alterations contribute to sensory reactivity at the affective level, leading in turn to increased IU and anxiety. This stepwise association can inform potential interventions for IU and anxiety in autism.
This study evaluated the impact of three distinct diets; perennial ryegrass (GRS), perennial ryegrass/white clover (CLV) and total mixed ration (TMR), on the sensory properties and volatile profile of whole milk powder (WMP). The samples were evaluated using a hedonic sensory acceptance test (n = 99 consumers) and by optimised descriptive profiling (ODP) using trained assessors (n = 33). Volatile profiling was achieved by gas chromatography mass spectrometry using three different extraction techniques; headspace solid phase micro-extraction, thermal desorption and high capacity sorptive extraction. Significant differences were evident in both sensory perception and the volatile profiles of the WMP based on the diet, with WMP from GRS and CLV more similar than WMP from TMR. Consumers scored WMP from CLV diets highest for overall acceptability, flavour and quality, and WMP from TMR diets highest for cooked flavour and aftertaste. ODP analysis found that WMP from TMR diets had greater caramelised flavour, sweet aroma and sweet taste, and that WMP from GRS diets had greater cooked aroma and cooked flavour, with WMP derived from CLV diets having greater scores for liking of colour and creamy aroma. Sixty four VOCs were identified, twenty six were found to vary significantly based on diet and seventeen of these were derived from fatty acids; lactones, alcohols, aldehydes, ketones and esters. The abundance of δ-decalactone and δ-dodecalactone was very high in WMP derived from CLV and GRS diets as was γ-dodecalactone derived from a TMR diet. These lactones appeared to influence sweet, creamy, and caramelised attributes in the resultant WMP samples. The differences in these VOC derived from lipids due to diet are probably further exacerbated by the thermal treatments used in WMP manufacture.
This article explores avian experiences with toxic war processes that unfold across space and time. Joining together three evolving areas of interest in global politics – ontologies of war, interspecies relations, and sensory politics – the article develops a view of war that centres ongoing war processes that affect more-than-human life in and outside of international warzones. Advancing a multispecies form of inquiry attentive to local voices, including Upper Cook Inlet Tribes, the article examines how interspecies relations emerge in national security debates about long-lasting ecological costs of war. Specifically, it offers an analysis of US Department of Defense hearings surrounding the controversy over reopening Eagle River Flats – an Alaskan estuary that had been polluted with white phosphorus munitions – for weapons testing and training during the Iraq War. The article also considers the experiences of two migratory avian communities (northern pintails and tundra swans) with toxic white phosphorus pollution, illustrating more-than-human sensory perspectives on the space and time of war processes. These conceptual and empirical moves reposition national security concerns about wartime risk into a much broader post-anthropocentric perspective.
Creating individualised activities in partnership with people who have moderate dementia and their partners at home has rarely been achieved, as such interventions are usually pre-planned by researchers or professionals. The academic gap is in the activity design being led by the person who has dementia and their partner and how to engage them in a meaningful manner which rekindles positive joint memories and improves the quality of their current relationship. This article explores the meaning and significance of recalling shared holiday memories for people living with moderate dementia and their partners, using multisensory reminiscence. A sensory ethnography research methodology was employed which enhanced co-design of the activity over five home visits. The research culminated in the creation of a digital story, sharing of food and drink, and re-enactment through exploration of their holiday memorabilia: forming their suitcase of memories (SOM). The study extends the current academic debate of co-produced interventions and identifies the critical themes of ‘holidays as life’, ‘freedom’, ‘view seen, viewpoint heard’ and ‘strengthened self-identity with younger self’ which emerged from the research. Such areas of sensory reminiscence have supported positive recollections, discourse and, when combined, resulted in a beneficial impact on the partner's shared relationship. A significant research outcome was the transition from a negative life view dominated by dementia to rekindling their relationship positively as a result of the SOM intervention and sensory methodology. Future research to continue the work with new couples to see if similar results are achieved with more case studies is needed.
This paper aims to develop a sensory methodological framework to explore older user's landscape experience. Applying empirical experience in Australian aged-care facilities, it addresses a methodological gap in the current literature to help move beyond the current taken-for-granted approaches such as interviews, cognitive mapping, behavioural observation and visual methods. We propose a more holistic method which enables the exploration of older people's in situ environmental experience. The multisensory framework we propose here is based on the first author's doctoral fieldwork experience that took place in two aged-care facilities in Brisbane, Australia. Findings suggest this framework facilitates an understanding of users’ olfactory, auditory and visual responses to the physical environment, and promotes a deeper engagement with the landscape. We argue that this is essential to promoting good landscape design which genuinely connects with older people's needs.
Consumption is driven by children’s sensory acceptance, but little is known about the sensory characteristics of vegetables that children commonly eat. A greater understanding could help design more effective interventions to help raise intakes, thus realising beneficial health effects. This study sought to: (1) Understand the vegetable consumption patterns in children, with and without potatoes, using the Australian and WHO definitions. (2) Describe the sensory characteristics of vegetables consumed by children by age group, level of intake and variety. (3) Determine the vegetable preferences of children, by age group, level of intake and variety.
Design:
Analysis of National Nutrition Survey data, combining reported vegetable intake with sensory characteristics described by a trained panel.
Setting:
Australia
Participants:
A nationally representative sample of Australian children and adolescents aged 2–17·9 years (n 2812).
Results:
While consumption increased in older age groups, variety remained constant. Greater variety, however, was associated with higher vegetable consumption. Potato intake increased with consumption, contributing over one-third of total vegetable intake for highest vegetable consumption and for older age groups. Children favoured relatively sweet vegetables and reported lower consumption of bitter vegetables. There were no differences in the sensory properties of vegetables consumed by children in different age groups. After potatoes, carrots, sweetcorn, mixtures, fruiting and cruciferous types were preferred vegetables.
Conclusion:
Children tend to prefer vegetables with sensory characteristics consistent with innate taste preferences (sweet and low bitterness). Increasing exposure to a variety of vegetables may help increase the persistently low vegetable consumption patterns of children.
Changes in sensory systems are common as we get older and become more likely with increasing age. In the auditory system, age-related changes are seen in domains such as auditory sensitivity, temporal processing, and spatial localization, which have significant effects on speech understanding. In vision, age-related changes are seen in contrast sensitivity, scotopic processing, and visual processing speed, which have consequences for activities such as reading and driving. Aging is also associated with changes in smell, taste, and balance. Beyond simple perceptual processing, age-related sensory changes can increase cognitive demands, requiring greater involvement of domain-general cognitive processes during perception that reduce resources available for other operations. Capturing individual variability in sensory changes and their consequences is an important part of understanding normal and pathological aging.
Settler colonialism entails the absorption of Indigenous peoples and their territories by a state that assumes jurisdiction over them without their meaningful consent, and the United States, therefore, is a settler-state, one founded and maintained through processes of settler colonialism. How, then, do nonnatives experience their relation to the space(s) claimed by/as the settler state? In his running return to the question of how national identity relates to forms of quotidian sensory life, Walt Whitman offers what might be understood as a theorization of settler sensation. Even as he explicitly endorses expansionism, he explores how everyday nonnative perception confirms the givenness of settlement by taking it as the implicit frame through which the landscape, and one’s relation to it, gains meaning. In doing so, he implicitly explores how settlers efface ongoing histories of Indigenous collective placemaking and normalize processes of dispossession.