In previous work by Coates, Galkin and the authors, the notion of mutation between lattice polytopes was introduced. Such mutations give rise to a deformation between the corresponding toric varieties. In this paper we study one-step mutations that correspond to deformations between weighted projective planes, giving a complete characterization of such mutations in terms of T-singularities. We also show that the weights involved satisfy Diophantine equations, generalizing results of Hacking and Prokhorov.