This note corrects an error in the formula to obtain the Whittle index using the Sherman–Morrison formula in Akbarzadeh and Mahajan (2022). Also, some other minor typos are highlighted.

Restless bandits are a class of sequential resource allocation problems concerned with allocating one or more resources among several alternative processes where the evolution of the processes depends on the resources allocated to them. Such models capture the fundamental trade-offs between exploration and exploitation. In 1988, Whittle developed an index heuristic for restless bandit problems which has emerged as a popular solution approach because of its simplicity and strong empirical performance. The Whittle index heuristic is applicable if the model satisfies a technical condition known as indexability. In this paper, we present two general sufficient conditions for indexability and identify simpler-to-verify refinements of these conditions. We then revisit a previously proposed algorithm called the adaptive greedy algorithm which is known to compute the Whittle index for a sub-class of restless bandits. We show that a generalization of the adaptive greedy algorithm computes the Whittle index for all indexable restless bandits. We present an efficient implementation of this algorithm which can compute the Whittle index of a restless bandit with K states in $\mathcal{O}\!\left(K^3\right)$ computations. Finally, we present a detailed numerical study which affirms the strong performance of the Whittle index heuristic.

In a rare life-threatening disease setting the number of patients in the trial is a high proportion of all patients with the condition (if not all of them). Further, this number is usually not enough to guarantee the required statistical power to detect a treatment effect of a meaningful size. In such a context, the idea of prioritizing patient benefit over hypothesis testing as the goal of the trial can lead to a trial design that produces useful information to guide treatment, even if it does not do so with the standard levels of statistical confidence. The idealized model to consider such an optimal design of a clinical trial is known as a classic multi-armed bandit problem with a finite patient horizon and a patient benefit objective function. Such a design maximizes patient benefit by balancing the learning and earning goals as data accumulates and given the patient horizon. On the other hand, optimally solving such a model has a very high computational cost (many times prohibitive) and more importantly, a cumbersome implementation, even for populations as small as a hundred patients. Several computationally feasible heuristic rules to address this problem have been proposed over the last 40 years in the literature. In this paper, we study a novel heuristic approach to solve it based on the reformulation of the problem as a Restless bandit problem and the derivation of its corresponding Whittle Index (WI) rule. Such rule was recently proposed in the context of a clinical trial in Villar, Bowden, and Wason [16]. We perform extensive computational studies to compare through both exact value calculations and simulated values the performance of this rule, other index rules and simpler heuristics previously proposed in the literature. Our results suggest that for the two and three-armed case and a patient horizon less or equal than a hundred patients, all index rules are a priori practically identical in terms of the expected proportion of success attained when all arms start with a uniform prior. However, we find that a posteriori, for specific values of the parameters of interest, the index policies outperform the simpler rules in every instance and specially so in the case of many arms and a larger, though still relatively small, total number of patients with the diseases. The very good performance of bandit rules in terms of patient benefit (i.e., expected number of successes and mean number of patients allocated to the best arm, if it exists) makes them very appealing in context of the challenge posed by drug development and treatment for rare life-threatening diseases.

Motivated by a wide range of applications, we consider a development of Whittle's restless bandit model in which project activation requires a state-dependent amount of a key resource, which is assumed to be available at a constant rate. As many projects may be activated at each decision epoch as resource availability allows. We seek a policy for project activation within resource constraints which minimises an aggregate cost rate for the system. Project indices derived from a Lagrangian relaxation of the original problem exist provided the structural requirement of indexability is met. Verification of this property and derivation of the related indices is greatly simplified when the solution of the Lagrangian relaxation has a state monotone structure for each constituent project. We demonstrate that this is indeed the case for a wide range of bidirectional projects in which the project state tends to move in a different direction when it is activated from that in which it moves when passive. This is natural in many application domains in which activation of a project ameliorates its condition, which otherwise tends to deteriorate or deplete. In some cases the state monotonicity required is related to the structure of state transitions, while in others it is also related to the nature of costs. Two numerical studies demonstrate the value of the ideas for the construction of policies for dynamic resource allocation, most especially in contexts which involve a large number of projects.

A multiarmed bandit problem is studied when the arms are not always available. The arms are first assumed to be intermittently available with some state/action-dependent probabilities. It is proven that no index policy can attain the maximum expected total discounted reward in every instance of that problem. The Whittle index policy is derived, and its properties are studied. Then it is assumed that the arms may break down, but repair is an option at some cost, and the new Whittle index policy is derived. Both problems are indexable. The proposed index policies cannot be dominated by any other index policy over all multiarmed bandit problems considered here. Whittle indices are evaluated for Bernoulli arms with unknown success probabilities.