This chapter reviews functional neuroimaging findings in the dorsal and ventral systems, as well as in other brain regions. Multiple functional imaging studies indicate basal ganglia dysfunction in bipolar disorder (BD). The chapter provides a more generalized review of functional abnormalities of the prefrontal cortex (PFC) in BD. Several functional magnetic resonance imaging (fMRI) studies have demonstrated primary motor cortex and supplementary motor area (SMA) dysfunction in BD. Functional imaging studies of pediatric BD to date have found evidence of abnormalities of the dorsal and ventral emotional control systems as well as other brain regions also implicated in adult BD. The studies reviewed in the chapter provide compelling evidence of dorsal and ventral system dysregulation in BD. The chapter provides considerable evidence of dysfunction in other brain regions including temporal, posterior cingulate, motor, parietal, occipital, and cerebellar regions. Most studies have examined medicated subjects, which introduce a significant potential confound.