This paper introduces the CPW fed monopole antenna operating at multiple frequencies covering Ultra High Frequency (UHF) bands, suitable for biomedical applications. The planar antenna structure comprises an open loop and a dual folded monopole of optimized length. The antenna exhibits ultra-wideband frequency of operation ranges from 740 MHz to 4.02 GHz covering the frequency bands suitable for head imaging and heart failure detection. The proposed antenna has a compact size of 0.098λ × 0.079λ × 0.019λ where λ indicates wavelength corresponding to the lowest operating frequency. The antenna is further simulated on the human head model to corroborate applications for brain stroke detection. The specific absorption rate (SAR) value of the proposed antenna is compliant with SAR requirements set by IEEE standards. To experimentally verify the parameters of the proposed antenna design, the antenna is tested on the brain tissue model prepared by materials having dielectric properties like human brain tissue. The peak gain of the antenna, when tested on the human phantom, is 6.8 dBi.