Many multiple planet systems have been found by both radial velocity (RV) and transit surveys, such as the Kepler mission. Period ratio distribution of these planet candidates show that they do not prefer to be in or near Mean Motion Resonance (MMR). Nevertheless, there are small but significant excesses of candidate pairs both spaced slightly exterior to exact resonance, particular near the first order of MMR, such as 2:1 and 3:2. Here, we first review recent observational constraints on these multiple transiting systems and theoretical models, which attempt to understand their period ratio distributions. Then we identify a statistical effect based on an intrinsic asymmetry associated with MMR, and find it play an important role in shaping the period ratio distribution near MMR. Last but least, we also find such an intrinsic asymmetry is existing in asteroids of our solar system.