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Many stroke research trials do not include assessment of cognitive function. A Very Early Rehabilitation Trial (AVERT) is an international multicenter study that includes the Montreal Cognitive Assessment (MoCA) as an outcome. At the Malaysian AVERT site, completion of the MoCA has been limited by low English proficiency in some participants. We aimed to develop a Bahasa Malaysia (BM) version of the MoCA and to validate it in a stroke population.
Methods:
The original English version of the MoCA was translated into BM and then back-translated to ensure accuracy. Feasibility testing in a group of stroke patients prompted minor changes to the BM MoCA. In the validation phase, a larger group of bilingual stroke patients completed both the original English MoCA and the finalized BM MoCA, with presentation order counter-balanced.
Results:
Forty stroke patients participated, with a mean age of 57.2 (SD = 10.3). Agreement between BM MoCA and English MoCA was strong (intra-class correlation coefficient = 0.81, 95% CI 0.68–0.90). Scores on BM MoCA were slightly higher than scores on English MoCA (median absolute difference = 2.0, IQR 0–3.5), and this difference was present regardless of which version was completed first.
Conclusions:
The existence of a validated BM version of the MoCA will be of major benefit to clinicians and researchers in Malaysia and the wider South-east Asian region, where the Malay language is used by over 200 million people.
In Takayasu disease, the aortic arch, with its main arterial trunks and the descending aorta, as well as renal arteries, is the main site of inflammation. Takayasu disease is thought to begin clinically with symptoms of systemic inflammation or with eye symptoms. Cerebral vascular disease is usually a consequence of severe hypertension, or carotid or brachiocephalic obstruction. Recently, it has been emphasized that use of Doppler ultrasound, computed tomography angiography, and positron emission tomography (PET) scan, magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) in combination, may facilitate the detection of Takayasu disease activity at a more treatable stage. Concerning the treatment and management of Takayasu disease patients with stroke, one has to consider the treatment of Takayasu disease and stroke separately. Subclavian steal syndrome or moderate carotid stenosis, as well as renal artery stenosis may be an indication for angioplasty and/or stenting.
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