Thanks to the explosion of methods and hermeneutical frameworks that have surfaced in biblical studies since the 1970s, the discipline looks very different today than when Catholic scholars were first openly permitted to engage it. Among these approaches are those that foreground the complex role the real flesh-and-blood reader plays in interpretation. Recent discussion on what makes biblical interpretation “Catholic” reveals it to be a contested topic. Through an analysis of the Pontifical Biblical Commission's The Interpretation of the Bible in the Church and Frank M. Yamada's article “What Does Manzanar Have to Do with Eden? A Japanese American Interpretation of Genesis 2–3,” the present article enters the discussion over what constitutes Catholic biblical interpretation to argue that it must integrate hermeneutical approaches that foreground real readers within the context of lived realities.