The European public sector has for a long time tried to change its activities and its relation to the public through the production and provision of data and data-based technologies. Recent debates raised attention to data uses, through which societal value may be realized. However, often absent from these discussions is a conceptual and methodological debate on how to grasp and study such uses. This collection proposes a turn toward data practices—intended here as the analysis of data uses and policies, as they are articulated, understood, or turned into situated activities by different actors in specific contexts, involving organizational rules, socioeconomic factors, discourses, and artifacts. Through a mix of conceptual and methodological studies, the contributions explore how data-driven innovation within public institutions is understood, imagined, planned for, conducted, or assessed. The situations examined in this special issue show, for instance, that data initiatives carried out by different actors lack institutional rules to align data use to the actual needs of citizens; that data scientists are important moral actors whose ethical reasoning should be fostered; and that the materiality of data practices, such as databases, enables and constrains opportunities for public engagement. Collectively, the contributions offer new insights into what constitutes “data-driven innovation practices,” how different practices are assembled, and what their different political, moral, economic, and organizational implications are. The contributions focus on three particular topics of concern: the making of ethical and normative values in practice; organizational collaborations with and around data; and methodological innovations of studying data practices.