Bilinguals activate both of their languages as they process written words, regardless of modality (spoken or signed); these effects have primarily been documented in single word reading paradigms. We used eye-tracking to determine whether deaf bilingual readers (n = 23) activate American Sign Language (ASL) translations as they read English sentences. Sentences contained a target word and one of the two possible prime words: a related prime which shared phonological parameters (location, handshape or movement) with the target when translated into ASL or an unrelated prime. The results revealed that first fixation durations and gaze durations (early processing measures) were shorter when target words were preceded by ASL-related primes, but prime condition did not impact later processing measures (e.g., regressions). Further, less-skilled readers showed a larger ASL co-activation effect. Together, the results indicate that ASL co-activation impacts early lexical access and can facilitate reading, particularly for less-skilled deaf readers.