Since the recognition of mycotoxicosis about 30 years ago, various research projects have been undertaken to develop measures to prevent or reduce the serious financial losses it causes. Although inhibitors which prevent mould growth and the production of toxic substances have been developed, several factors still limit their effectiveness and practical use by the feed industry. Various kinds of sorbent materials have also been assessed for their ability to remove or diminish the adverse effects of mycotoxins in animal feeds. Even though it does not bind all the mycotoxin and allows partial absorption of toxin in the gastrointestinal tract, hydrated sodium calcium aluminosilicate (HSCAS) is considered to be an outstandingly effective additive. Several new possibilities have emerged involving the use of the sulphur-containing amino acids, antioxidants, vitamins, trace mineral and other nutrients in building detoxicants. Research into methods of preventing mycotoxicosis in poultry needs to be carried out against the background of the underlying levels of mycotoxins found under the normal storage conditions for feed used in the industry.