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1 results

  • Chapter 12 - Sample Size Calculations

  • Jos W. R. Twisk, Amsterdam University Medical Centers
  • Book:
    Applied Longitudinal Data Analysis for Medical Science
    Published online:
    20 April 2023
    Print publication:
    27 April 2023, pp 216-219

  • Summary

    In Chapter 12 sample size calculations for longitudinal studies are discussed. It is shown that a sample size calculation for longitudinal studies is based on the standard sample size calculation formula with an additional multiplication factor which includes the number of follow-up measurements and the estimated correlation between the repeated measurements. Sample size calculations for both a continuous and a dichotomous outcome variable are illustrated with an example. Besides the practical part of the sample size calculation, the chapter also includes a discussion regarding the sense or nonsense of sample size calculations.