This study examines the factors influencing women farmers’ choice of adaptation strategies to reduce the negative impacts of climate change and the effects of these strategies on household income and food insecurity. A field survey was conducted among 426 women farmers in the Center-North region, which covers 7% of Burkina Faso territory. Descriptive statistics, a multinomial logit model, and a propensity score matching model were used to analyze the data collected. The results of the econometric analysis show that high domestic tasks, type of climate shocks experienced, membership in women’s group, and financial constraints are important determinants of adaptation decisions. Adaptation strategies are also found to have a positive impact on income and a negative impact on household food insecurity. These different findings highlight the need to prioritize flexible adaptation options to improve women farmers’ resilience to climate change, rather than generic solutions.