Researchers have studied truck crashes extensively using methods appropriate for behavior, technology, and regulatory enforcement. Few safety studies associate crashes with economic pressure, a pervasive latent influence. This study uses data from the US Large Truck Crash Causation Study to predict truck crashes based on work pressure factors that have their origins in market pressures on motor carriers and truck drivers. Logistic regression shows that factors associated with the work process, including an index of work-pressure attributes, predict the likelihood that crash analysts consider the truck driver to be the person whose last action could have prevented the crash. While not proving causation, the data suggest that economic factors affecting drivers contribute significantly to truck crashes.