In Peru, eradication campaigns targeting coca crops in the Upper Huallaga have dispersed the country's drug trade over vast parts of the Bajo Amazonas region. In order to understand this dispersal it is necessary to map the relocations of coca cultivations or shifts in smuggling routes, but also to examine the array of micro-practices, relations, groups and networks that generate ‘drug flows’. By following different key actors, this article explores the movements of drug lords, smugglers and producers who intersect frontiers, borders and borderlands. This empirical focus is combined with an analysis of the actors’ social ties to other groups to discover the myriad ways in which illegal/legal forces are part of the power arrangements that form the foundation for Peru's drug flows.