This article is an introduction and guide to investigating past relationships between climate and human behavior. Improving understanding of these relationships is essential as humanity confronts the challenges of our warming world. However, how to investigate potential climatic influences on human behavior in the past is rarely presented or discussed as a distinct mode of inquiry. This article aims to fill this gap by providing a practical tool kit for students, archaeologists, anthropologists, and other historically focused social scientists. It is structured as a series of seven key steps to creating a research design for a climate and human behavior study, from identifying research questions to presenting results. Most of the conceptual models, methods, data, and examples provided have worldwide relevance and are informed by the long history of climate and human behavior studies in the North American Southwest. By expanding competence in this domain, we can enrich documentation and interpretations of the past and insights will emerge that will contribute to preparing for and responding to our warming world.